Aminopyrimidine inhibitors of histamine receptors for the treatment of disease

Abstract

The present invention relates to compounds and methods which may be useful as inhibitors of HiR and / or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

Description

[0001] This application claims the benefit of priority from US Provisional Patent Application Serial No. 61 / 095,819, filed September 10, 2008, the disclosure of which is hereby incorporated by reference as if incorporated herein in its entirety. technical field [0002] Disclosed herein are novel heterocyclic compounds and compositions, and their use as medicaments for the treatment of disease. Also provided are methods of inhibiting the activity of histamine receptors in a human or animal subject for the treatment of allergic disease, inflammation, asthma, rhinitis, chronic obstructive pulmonary disease, conjunctivitis, rheumatoid arthritis, and generalized and localized pruritus disease. Background technique [0003] Histamine, a low molecular weight biogenic amine, is a potent chemical modulator of normal and pathophysiology. Histamine functions as a secreted signal and neurotransmitter of immune and inflammatory responses. Through four different cell surface receptors ...

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