Preparation method of total alkali of corydalis tuber, and corydalis tuber preparation and use thereof
A technology for total alkaloids and preparations of Corydalis Corydalis, applied in the field of preparation of traditional Chinese medicine extracts, can solve the problems of low solvent recovery rate, high production cost, low production efficiency and the like, and achieve the effects of high purity, high production cost and low recovery rate
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Embodiment 1
[0058] Corydalis coarse powder 10kg, extract with 75% ethanol (with 10%~30% acetic acid to adjust the pH value to 2-3) to extract for 2 hours each time, extract three times, combine the extracts, concentrate under reduced pressure, adjust the concentrated solution to pH=2~3 3. Apply the acid solution to the macroporous resin D101 column, rinse with water, and then elute with 85% ethanol. The eluate is extracted three times with water-saturated ethyl acetate (1:1), and concentrated to a specific gravity of 1.10-1.12. Freeze-dry to obtain 120g of total alkaloids.
Embodiment 2
[0060] Corydalis coarse powder 10kg, extract with 85% methanol (with 10%~30% acetic acid to adjust the pH value to 2-3) to extract for 2 hours each time, extract three times, combine the extracts, concentrate under reduced pressure, adjust the concentrated solution to pH=2~3 3. Apply the acid solution to the macroporous resin AB-8 column, rinse with water, and then elute with 85% ethanol. The eluate is extracted three times with water-saturated ethyl acetate (1:1), and concentrated to a specific gravity of 1.10- 1.12, freeze-dried to obtain 116g of total alkaloids.
Embodiment 3
[0062] Corydalis coarse powder 10kg, extract with 85% ethanol (adjust pH value 2-3 with acetic acid), extract 2 hours each time, extract three times, combine extracts, concentrate under reduced pressure, be concentrated to specific gravity 1.10-1.15, concentrated solution alkalization (with ammonia water) to a pH value of 8-9, extracted three times with petroleum ether (1:1), then extracted three times with water-saturated ethyl acetate (1:1), concentrated to a specific gravity of 1.10-1.12; lyophilized, frozen Dry to obtain 112g of total alkaloids.
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