Preparation method of total alkali of corydalis tuber, and corydalis tuber preparation and use thereof

A technology for total alkaloids and preparations of Corydalis Corydalis, applied in the field of preparation of traditional Chinese medicine extracts, can solve the problems of low solvent recovery rate, high production cost, low production efficiency and the like, and achieve the effects of high purity, high production cost and low recovery rate

Active Publication Date: 2011-09-21
傅宏征 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first purpose of the present invention is to provide a kind of preparation method of Corydalis total alkaloids, the method technology is simple, the total alkaloids extraction rate is high, the active effect of the composition of the extract is good, and solve the problem of banding when extracting with chloroform in the prior art The disadvantages of high volatility, serious emulsification, low solvent recovery rate, high production cost, low production efficiency, high toxicity and unfriendly environment

Method used

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  • Preparation method of total alkali of corydalis tuber, and corydalis tuber preparation and use thereof
  • Preparation method of total alkali of corydalis tuber, and corydalis tuber preparation and use thereof
  • Preparation method of total alkali of corydalis tuber, and corydalis tuber preparation and use thereof

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Experimental program
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Embodiment 1

[0058] Corydalis coarse powder 10kg, extract with 75% ethanol (with 10%~30% acetic acid to adjust the pH value to 2-3) to extract for 2 hours each time, extract three times, combine the extracts, concentrate under reduced pressure, adjust the concentrated solution to pH=2~3 3. Apply the acid solution to the macroporous resin D101 column, rinse with water, and then elute with 85% ethanol. The eluate is extracted three times with water-saturated ethyl acetate (1:1), and concentrated to a specific gravity of 1.10-1.12. Freeze-dry to obtain 120g of total alkaloids.

Embodiment 2

[0060] Corydalis coarse powder 10kg, extract with 85% methanol (with 10%~30% acetic acid to adjust the pH value to 2-3) to extract for 2 hours each time, extract three times, combine the extracts, concentrate under reduced pressure, adjust the concentrated solution to pH=2~3 3. Apply the acid solution to the macroporous resin AB-8 column, rinse with water, and then elute with 85% ethanol. The eluate is extracted three times with water-saturated ethyl acetate (1:1), and concentrated to a specific gravity of 1.10- 1.12, freeze-dried to obtain 116g of total alkaloids.

Embodiment 3

[0062] Corydalis coarse powder 10kg, extract with 85% ethanol (adjust pH value 2-3 with acetic acid), extract 2 hours each time, extract three times, combine extracts, concentrate under reduced pressure, be concentrated to specific gravity 1.10-1.15, concentrated solution alkalization (with ammonia water) to a pH value of 8-9, extracted three times with petroleum ether (1:1), then extracted three times with water-saturated ethyl acetate (1:1), concentrated to a specific gravity of 1.10-1.12; lyophilized, frozen Dry to obtain 112g of total alkaloids.

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Abstract

The invention relates to a preparation method of total alkali of corydalis tuber, and a corydalis tuber preparation and use thereof. The preparation method of the total alkali of corydalis tuber, which is prepared by the invention, comprises: grinding, extracting and post-treatment, wherein the post-treatment comprises extracting ethyl acetate, concentrating, freezing and drying. In the invention, an ethyl acetate extracting method is adopted, so the recovery is easy, the recovery rate is high, the toxicity is low, the environment pollution is avoided, and ethyl acetate is an ideal solvent for industrial production; and the drawbacks of high volatility, low recovery rate, high production cost, and high toxicity to human beings and the environment of the conventional biological alkali extraction solvents which mainly are chloroform are overcome, and the production cost is reduced. The ethyl acetate extraction purity reaches over 80 percent. The invention also provides a corydalis tubertotal alkali preparation and the use of the corydalis tuber total alkali preparation in the preparation of medicines for treating gynecological diseases, in particular the use of the corydalis tuber total alkali preparation in the preparation of medicines for treating dysmenorrheal, abnormal menstruation or endometriosis.

Description

technical field [0001] The present invention relates to a preparation method of a Chinese medicine extract and various preparations thereof, specifically a method for preparing a total alkali extract from Corydalis Corydalis (Yuanhu) and various preparations prepared from the total alkali extract, which are used for treating gynecological diseases. Dysmenorrhea, irregular menstruation, and endometriosis. Background technique [0002] Corydalis yanhusuo (Yuanhu) is the tuber of Corydalis yanhusuo W.T.Wang. Warm in nature and bitter in taste, promoting blood circulation and dispelling blood stasis, invigorating qi and relieving pain. Corydalis contains alkaloids, of which the content of tertiary amines is about 0.65%, and that of quaternary amines is about 0.3%. At present, more than 20 three types of alkaloids have been isolated, including: d-corydaline (d-C-orydaline or corydalis), dl-tetrahydropalmatine (dl-Tetrahydropalmatine or corydalin), Element opium base (Protopine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P15/00A61K125/00
Inventor 傅宏征李伟徐华
Owner 傅宏征
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