Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

L-arginine-glucose-insulin-potassium chloride composition and application thereof

A technology of arginine and glucose, which is applied in the direction of active ingredients of alkali/alkaline earth metal chlorides, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of low bioavailability and poor effect, reduce damage, The effect of reducing the size of infarcted heart

Inactive Publication Date: 2011-10-19
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1) Administration of nitroglycerin: Oral administration of nitroglycerin has an obvious "first-pass effect" and extremely low bioavailability, so the effect of oral nitroglycerin preparations is very poor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • L-arginine-glucose-insulin-potassium chloride composition and application thereof
  • L-arginine-glucose-insulin-potassium chloride composition and application thereof
  • L-arginine-glucose-insulin-potassium chloride composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] The L-arginine-glucose-insulin-potassium chloride composition provided by the present invention supplements exogenous L-Arg on the one hand, increases the L- Arg; on the other hand, activate eNOS in the cardiovascular system through GIK, enhance the production of endogenous NO, to strengthen the supply of NO, play a protective role in the heart, and make the damaged myocardium play a normal physiological function again, thereby reducing the myocardium in ischemia. damage, reduce the area of ​​infarcted heart, and promote the recovery of heart function. In the following, the present invention will be further described in detail in conjunction with the preparation of the L-arginine-glucose-insulin-potassium chloride composition and the perfusion of the rat ischemia model, which is an explanation rather than a limitation of the present invention.

[0022] 1. Preparation of L-arginine-glucose-insulin-potassium chloride composition:

[0023] Using sterile double distilled w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an L-arginine-glucose-insulin-potassium chloride composition which uses water as a solvent and comprises 5-10 wt% glucose, 20-50 IU / L insulin, 40-100 mmol / L potassium chloride and 1-50 g / L L-arginine. The L-arginine-glucose-insulin-potassium chloride composition supplements exogenous L-Arg, and activates the cardiovascular system eNOS through the glucose-insulin-potassium chloride, thereby enhancing the generation of endogenous NO, displaying the heart protective action, reducing the myocardial infarction and promoting the recovery of cardiac function. The composition can be used for preparing medicaments for resisting ischemic cardiac trauma or heart failure.

Description

technical field [0001] The invention belongs to the technical field of prevention and treatment of ischemic heart disease, and particularly relates to a composition of L-arginine-glucose-insulin-potassium chloride and application thereof. Background technique [0002] Ischemic heart disease is damage to the heart muscle due to an imbalance between coronary blood flow and the demands of the heart muscle caused by alterations in the coronary circulation. That is, on the basis of the original or no atherosclerotic plaque formation in the coronary arteries of the heart, the coronary artery lumen is narrowed or occluded due to thrombus formation caused by coronary artery spasm or endothelial injury. Conflict between blood, causing angina pectoris or myocardial infarction. Epidemiological survey The incidence of ischemic heart disease is increasing year by year. With the change of people's lifestyle, the disease has become an important disease that endangers human life and health...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/28A61P9/10A61P9/04A61K33/14A61K31/7004A61K31/198
Inventor 高峰董玲刘文冲付锋蔡晓庆李嘉
Owner FOURTH MILITARY MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com