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Calcium carbonate effervescent granule

A technology of effervescent granules and calcium carbonate, which is applied in the direction of active ingredients of aluminum/calcium/magnesium, medical preparations of non-active ingredients, metabolic diseases, etc. Increase the duration and increase the effect of Ph value

Active Publication Date: 2011-10-26
黄辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After a large number of follow-up investigations, it was found that the calcium carbonate effervescents currently on the market can achieve some calcium supplementation effects for those with achlorhydria, especially infants, children or the elderly, but the resulting hyperacidity The consequences of this are obviously counterproductive, and the harm outweighs the good

Method used

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  • Calcium carbonate effervescent granule
  • Calcium carbonate effervescent granule
  • Calcium carbonate effervescent granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Prescription for calcium carbonate effervescent granules 1000 bags:

[0103]

[0104] Preparation:

[0105] (1) 200g povidone K30 is dissolved in 2000ml 70% ethanol solution to make adhesive ethanol solution;

[0106] (2) mixing the calcium carbonate, sodium bicarbonate and lactose of the alkali group to obtain the alkali group mixture;

[0107] (3) Mixing the citric acid, lactose, sorbitol and protein sugar of the acid group to obtain the acid group mixture;

[0108] (4) Vitamin D 3 - Dissolve the β-cyclodextrin inclusion complex with 400ml of binder ethanol solution, add the alkali group mixture, mix well, then add 900ml binder ethanol solution, mix and granulate, and dry at 60°C to the water content Not higher than 2%, to obtain alkali group particles;

[0109] (5) adding the remainder of the binder ethanol solution into the acid group mixture, granulating, and drying until the water content is not higher than 2%, to obtain the acid group granules;

[0110] (...

Embodiment 2

[0113] Prescription for calcium carbonate effervescent granules 1000 bags:

[0114]

[0115]

[0116] Preparation:

[0117] (1) 100g povidone K90 is dissolved in 2000ml 80% ethanol solution to make adhesive ethanol solution;

[0118] (2) mixing the calcium carbonate, sodium bicarbonate and mannitol of the alkali group to obtain the alkali group mixture;

[0119] (3) mix the malic acid, mannitol, and sorbitol of the acid group to obtain the acid group mixture;

[0120] (4) Vitamin D 3 - Dissolve the β-cyclodextrin inclusion compound with 400ml of binder ethanol solution, add the base group mixture, mix well, add 900ml binder ethanol solution, mix and granulate, dry, to the base group granules;

[0121] (5) Add the remainder of the binder ethanol solution to the acid group mixture, granulate, and dry to obtain the acid group granules;

[0122] (6) Mix the alkali group granules and acid group granules obtained in steps (4), (5) to obtain calcium carbonate effervescent g...

Embodiment 3

[0124] Prescription for calcium carbonate effervescent granules 1000 bags:

[0125]

[0126] Preparation:

[0127] (1) 150g povidone K30 is dissolved in 1500ml 90% ethanol solution to make adhesive ethanol solution;

[0128] (2) mixing the calcium carbonate, sodium bicarbonate and microcrystalline cellulose of the alkali group to obtain the alkali group mixture;

[0129] (3) mixing the tartaric acid, microcrystalline cellulose, and stevioside of the acid group to obtain the acid group mixture;

[0130] (4) Vitamin D 3 - Dissolve the β-cyclodextrin inclusion compound with 350ml of binder ethanol solution, add the base group mixture, mix well, then add 600ml of binder ethanol solution, mix and granulate, dry under reduced pressure, granulate, and reach the base Group particles;

[0131] (5) adding the remainder of the binder ethanol solution to the acid group mixture, granulating, drying under reduced pressure, and sizing to obtain the acid group granules;

[0132] (6) M...

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Abstract

The invention provides a calcium carbonate effervescent granule. The weight ratio of the calcium carbonate effervescent granule is 1: 0.3 - 0.7: 1 - 2:0.3 - 0.5 of calcium carbonate, vitamin D, acidic foaming agent and sodium bicarbonate. The invention also provides a method for preparing the calcium carbonate effervescent granule; the calcium carbonate effervescent granule is used for supplying calcareous to human body or preventing and treating osteoporosis and children rickets.

Description

technical field [0001] The invention relates to an effervescent granule containing calcium carbonate, which belongs to the field of pharmaceutical preparations. The corresponding medicine name of the present invention, medicine Chinese common name is compound calcium carbonate granule. Background technique [0002] Calcium carbonate is currently the most widely used calcium supplement raw material because of its high calcium content, low price, and high safety. There are various dosage forms on the market, such as ordinary tablets, chewable tablets, capsules, soft capsules, granules, effervescent Granules, effervescent tablets, etc. [0003] Calcium carbonate is insoluble in water, and its ordinary solid preparation products need gastric acid to react with it to produce ionized calcium that can be absorbed by the human body. The expected purpose of calcium supplementation will cause adverse reactions such as indigestion and abdominal distension, so the effervescent agent o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K9/16A61K47/38A61P3/02A61P19/08A61P19/10A61K31/59
Inventor 黄辉
Owner 黄辉
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