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Application of isoflavonoids compounds to preparation of antihepatitis drug

Technology of a compound, isoflavones, applied in the fields of natural medicinal chemistry and medicine

Inactive Publication Date: 2011-11-23
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports on the anti-hepatitis virus of irisin, irisin, subirisanthin, irisaxanthin, and irisinin

Method used

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  • Application of isoflavonoids compounds to preparation of antihepatitis drug
  • Application of isoflavonoids compounds to preparation of antihepatitis drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 anti-hepatitis B virus test

[0018] 1. Experimental drugs, reagents and materials

[0019] Test drugs: irisin (1), irisin (2), irisin (3), irisanthin (4), irisin (5) (extraction and separation methods can refer to the inventor L. Jin(金丽), Y.S.Jin(金尸生), H.S.Chen(陈海生), at al.Phinolic constituents of Belamcanda chinensis Chemistry of Natural Comp 2007; 43(6):700-701; Jin Li(金丽), Chen Hai-sheng (Chen Haisheng), Jin Yong-Sheng (Jin Yongsheng), et al. Chemical constituents from Belamcanda chinensis Journal of Asian Natural Products Research 2008, 10(1): 89-91). Readable HBsAg Diagnostic Kit (Shanghai Kehua Biotechnology Co., Ltd.)

[0020] Readable HBeAg Diagnostic Kit (Shanghai Kehua Biotechnology Co., Ltd.)

[0021]Cell culture medium (10% fetal bovine serum, 0.03% glutamine, G418390μg / ml, kanamycin 50U / ml, adjust pH to 7.2)

[0022] Cell digestion solution (0.25% trypsin, prepared with phosphate buffer)

[0023] The HBV-DNA clone was transfected into the...

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Abstract

The invention relates to an application of isoflavonoids compounds, i.e., tectoridin, iridin, irisflorentin, tectorigenin or irigenin, separated from the belamcanda chinensis of an iridaceae belamcanda plant to preparation of drugs or health-care foods for preventing and treating hepatitis, relating to the technical field of natural pharmaceutical chemistry and medicines. In the invention, HBsAg (Hepatitis B Surface Antigen) and HBeAg(Hepatitis B e Antigen) resistance experiments are carried out by adopting detection reagents of an HBsAg diagnostic reagent kit and an HBeAg diagnostic reagent kit; and an experimental result discovers that all the tectoridin, the iridin, the irisflorentin, the tectorigenin and the irigenin have an obvious hepatitis B virus resistant action, thus the tectoridin, the iridin, the irisflorentin, the tectorigenin and the irigenin can be used for preparing the drugs or health-care foods for preventing and treating hepatitis viruses.

Description

technical field [0001] The present invention relates to the field of natural medicinal chemistry and medical technology, in particular to isoflavone compounds tectoridin, iridin, irisflorentin, Use of tectorigenin and irigenin in the preparation of medicines or health food for the prevention and treatment of hepatitis. Background technique [0002] Shegan is the dry rhizome of Belamcanda chinensis (L.) DC. Bitter and cold in taste, enters the liver and lung meridians, has the effects of clearing away heat and detoxification, relieving sore throat and eliminating phlegm, dispersing blood and reducing swelling, and mainly treating sore throat, phlegm, cough and asthma. It is a commonly used Chinese herbal medicine and is rich in resources. Studies have shown that Shegan is rich in isoflavones, which is one of its characteristic components. The main components that have been reported to be contained in Shegan are irisgenin, irisaxanthin, hypoirisin, irisoflavone neoaglycone ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/36A61K31/352A61P31/20A23L1/29A23L33/00
Inventor 陈海生金丽金永生刘建国赵卫权
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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