Method for preparing indigo naturalis

An indigo plant and plant technology, applied in the field of medicine, can solve the problems of affecting clinical efficacy, difficult to standardize the processing process, and uneven quality of indigo products, so as to expand the scope of clinical application, reduce the amount of lime, and achieve good product quality.

Inactive Publication Date: 2013-09-04
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research on the processing method of Indigo Naturalis only uses indigo as an index to control product quality. How to increase the content of indirubin or indigo in Indigo Naturalis is worth studying
In addition, the pH adjusted during the indigo production process is a key factor affecting the production of indigo and indirubin, and the actual dosage of milk of lime is entirely based on experience, which makes it difficult to standardize the processing technology, resulting in uneven quality of Indigo Naturalis finished products, affecting clinical efficacy play

Method used

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  • Method for preparing indigo naturalis
  • Method for preparing indigo naturalis
  • Method for preparing indigo naturalis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation of embodiment 1 thick indigo of the present invention

[0014] Place the fresh leaves in tap water at 25°C with a pH of about 3.5, wherein the volume of water: mass of fresh leaves (ml: g) is 13, soak in the dark for 24 hours, filter to remove leaf residue, add ammonia water to adjust the pH of the filtrate to 9, and then After ventilating the air for 30 minutes, add 10% fresh milk of lime (take 10% CaO of fresh leaves, add 10 times the amount of boiling water, stir continuously to form a suspension), stir well and let stand for 24 hours, filter Take the precipitate and dry it to get crude indigo.

Embodiment 2

[0015] The preparation of embodiment 2 thick indigo of the present invention

[0016] Place the fresh leaves in tap water at 60°C with a pH of about 7, wherein the volume of water: mass of fresh leaves (ml: g) is 15, soak for 48 hours, filter to remove leaf residue, ventilate the filtrate for 30 minutes, add ammonia water to adjust the pH of the filtrate to 10.5, after ventilating the air for 180 minutes, add 10% fresh milk of lime (take 10% CaO of fresh leaf mass, add 10 times the amount of boiling water, stir continuously to form a suspension), stir evenly and let stand After 24 hours, the precipitate was collected by filtration and dried to obtain crude indigo.

Embodiment 3

[0017] The process parameter selection of indigo directional generation in the rough indigo processing process of embodiment 3

[0018] 1. Instruments and reagents

[0019] Shimadzu LC-10ATvp high-performance liquid chromatography (Zhejiang Zhida N2000 chromatographic workstation); BP211D electronic analytical balance (Max=210g, d=0.01mg, Sartorius, Germany); KQ-400DB numerical control ultrasonic cleaner (Kunshan Ultrasonic Cleaner) Instrument Co., Ltd.); SZ-93 automatic double pure water distiller (Shanghai Yarong Biochemical Instrument Factory); LZB-FB rotameter (Suzhou Chemical Instrument Co., Ltd.); ACO series electromagnetic air compressor (Zhejiang Sensen Industry Co., Ltd.); SHB-ⅢS circulating water multi-purpose vacuum pump (Zhengzhou Great Wall Technology Industry and Trade Co., Ltd.)

[0020] Malan stems and leaves (provided by Sichuan Jiangyou Hengyuan Pharmaceutical); indigo (National Institute for the Control of Pharmaceutical and Biological Products, batch numbe...

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Abstract

The invention provides a method for preparing indigo naturalis, comprising the following steps of: a, placing leaves or stem leaves of strobilanthus (acanthaceae), indigo (polygonaceae) or woad (crucifer) into water with the pH value of 3.5-7 at the temperature of 25-60 DEG C, the mass ratio of water to the fresh leaves is 8-15, soaking for 24-48 hours, and filtering and removing leaf slag to obtain filtrate; b, introducing air into the filtrate for 0-30min, adding alkaline to regulate the pH value to be 9-10.5, introducing the air for 30-240min, adding lime milk, stirring to be uniform and standing, filtering to obtain precipitate, drying to obtain crude indigo, and refining the crude indigo to finally obtain the indigo naturalis. In the crude indigo prepared by adopting the method provided by the invention, contents of indigo blue and indirubin are higher, and product quality is good.

Description

technical field [0001] The invention relates to a method for processing Qingdai, which belongs to the field of medicines. Background technique [0002] Indigo Daisy is the dry powder or agglomerate obtained by processing the leaves or stems and leaves of the Acanthaceae plant Malan, Polygonaceae plant Polygonum indigo or Cruciferae plant Isatis indigo. The processing process is the process of transforming the precursor substances in the stems and leaves of horse blue into indigo and indirubin, mainly including soaking, rough indigo preparation, and water refining. The traditional processing method is: Harvest the stems and leaves in autumn, put them in the soaking pool, introduce river water, submerge them completely, soak and ferment for several days, when the pool liquid turns dirty green, remove the residue, put in lime, and fully stir. Stand still for 1 to 2 days, discard the supernatant, collect the sediment at the bottom and move it to a small pond, let it stand, and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/19A61K36/315A61K36/704
Inventor 杨明傅超美许润春刘泽玉苏柘僮
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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