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A New Multifunctional Hemostatic Dressing

A hemostatic dressing, a multi-functional technology, applied in bandages, absorbent pads, medical science, etc., can solve the problems of analgesia, anti-infection, promotion of healing, less research and development, and limited hemostasis of hemostatic materials, so as to easily form gel and promote wound healing Healing, antibacterial and antibacterial effects

Active Publication Date: 2011-11-30
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing hemostatic materials are limited to simple hemostasis, and there are relatively few researches and developments on analgesia, anti-infection, and promotion of healing.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] 1. Preparation of different deacetylated chitosans; after chitin is treated with concentrated alkali solution, the acetamide group in the molecule will be partially hydrolyzed and removed, and when more than half of the acetyl groups in the molecule are removed, it will become chitosan. Since the acetamide group on the C2 position of the chitin monomer replaces the hydroxyl group, it is insoluble in dilute acids, dilute alkalis and organic solvents, and its properties are similar to cellulose. When more than half of the acetyl groups are removed, it can be dissolved in acids. When chitosan is dissolved in an acidic solution, the free amine group (-NH2) on the monomer molecule is protonated and positively charged (-NH3+) becomes a cationic polymer, which can adsorb some negatively charged substances. In this experiment, chitosan with higher molecular weight (9.3×105~9.8×105) was further studied on coagulation-promoting and antibacterial properties of chitosan with differe...

Embodiment 1

[0027] Embodiment 1. The preparation of novel multifunctional hemostatic dressing, prepares corresponding chitosan, collagen and chrysophanol according to above-mentioned steps (1) (2) (3) method, carries out the compound of different proportioning by step (4) .

[0028] The obtained collagen, chitosan, and chrysophanol composite material was cross-linked and freeze-dried, and covered the bleeding mouse site after limb injury. The hemostatic effect was observed, and it was found that the bleeding stopped after 1 minute. However, collagen was simply used as a hemostatic material to cover the bleeding site of the same injured mouse, and the bleeding stopped after 5 minutes. Chitosan was simply used as a hemostatic material to cover the bleeding site of the same injured mouse, and the bleeding stopped after 4 minutes. A composite material of collagen and chitosan was used to cover the bleeding site of the same injured mouse, and the bleeding stopped after 2 minutes.

Embodiment 2

[0029] Embodiment 2. The preparation of novel multifunctional hemostatic dressing, prepares corresponding chitosan, collagen and chrysophanol according to above-mentioned steps (1) (2) (3) method, carries out the composite of different proportioning by step (4) .

[0030] The obtained collagen, chitosan, and chrysophanol composite materials were cross-linked and freeze-dried, and the same culture conditions were used to cultivate staphylococcus and anaerobic bacteria. It was observed that the growth of bacteria was significantly inhibited after the composite material of collagen, chitosan and chrysophanol was cultured overnight, while the growth of bacteria on the pure collagen material was vigorous. The number of bacterial growth on the pure chitosan material was lower than that of the collagen group but higher than that of the composite material group of collagen, chitosan and chrysophanol. The number of bacteria growing on the composite material of collagen and chitosan is...

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Abstract

The novel multifunctional hemostatic dressing that the present invention relates to is characterized in that: adopt following method to prepare: 1, the preparation of chitosan of different degrees of deacetylation; 2, the preparation of modified collagen: control the degree of chemical modification of collagen, molecular integrity properties, molecular weight and concentration; 3. Purification of chrysophanol; obtain the effective substance of hemostasis in rhubarb, a traditional Chinese medicine, and conduct quantitative research; 4. Organically compound collagen, chitosan and chrysophanol to ensure the flexibility of the freeze-dried pad composite sponge The adventitia has tightness, adhesion and integrity; the new multifunctional hemostatic dressing can quickly stop bleeding, anti-inflammatory and analgesic and promote healing, and can be used for hemostatic repair of military war wounds and as a general hemostatic first aid for civilians .

Description

technical field [0001] The invention relates to a multifunctional hemostatic dressing capable of rapid hemostasis, anti-inflammation and pain relief, and promotion of healing. technical background [0002] Trauma hemorrhage is one of the important diseases that endanger human health and life safety. Regardless of war or peacetime, uncontrollable hemorrhage is the main cause of death of the wounded. In the war, there is a relatively large proportion of casualties caused by blood loss. According to statistics, about 50% of the dead died within a few minutes due to excessive blood loss before being sent to the ambulance station. Injury and bleeding in various emergencies in peacetime are also extremely common. The rising trend of traffic accidents and casualties in my country is a typical example. Excessive traumatic blood loss can cause pain, coma, shock and even death in the wounded. Hemostasis has become an important part of first aid for war injuries and sudden accidents....

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/44
Inventor 朱楚洪蒋波曾文李立糜建红
Owner ARMY MEDICAL UNIV
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