Formula of compound dendrobium huoshanense granules and production method

A technology of Dendrobium huoshanense granules and production method, which are applied in directions such as pharmaceutical formulations, medical preparations containing active ingredients, and bulk transportation, can solve the problems of slow dissolution rate, influence on product quality, inconvenience in use, etc., and achieve convenient administration and solution. Low dissolution rate and quality improvement effect

Active Publication Date: 2013-04-10
JIUXIANZUN HUOSHAN DENDROBIUM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dendrobium Huoshanense contains a large amount of crude polysaccharides. The traditional method of taking Dendrobium Huoshanense often causes the dissolution rate of active ingredients to be very low due to uneven cooking and unreasonable cooking time, which causes a great waste of active ingredients in Dendrobium Huoshanense
And because the viscosity of the crude polysaccharide is very large, it is difficult to filter under normal pressure, which greatly affects the quality of the product
Dendrobium Huoshanense polysaccharides have a large molecular weight, and the dissolution rate is slow. When boiling soup and tea at 100°C under normal pressure for 10 hours, the dissolution rate of polysaccharides is only 20%, which is very inconvenient to use.
[0005] Dendrobium Huoshanense has been used in the form of a single medicinal material for a long time, while traditional Chinese medicine pays attention to the complementarity of the monarch and the subject, reasonable compatibility, and complementary medicinal effects, so the traditional utilization effect is extremely poor
[0006] At present, the traditional Chinese medicine compound preparations containing dendrobium raw materials researched and developed in China have different drug compositions, dosage forms and preparation processes, and the contained crude polysaccharides, total saponins and other effective ingredients are also high and low. The compound Huoshan The formula and production method of Dendrobium granules have not been reported in the literature in China, and the existing Dendrobium granules on the market are all made of Dendrobium officinale, and there is no involvement in Huoshan Dendrobium (Middrobium), which has real medicinal value.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The invention discloses a formula of compound Dendrobium Huoshanense granule, which comprises: Dendrobium Huoshanense, American ginseng, Ningxia wolfberry and lactose.

[0032] The weight percentages of each formula are as follows: Dendrobium Huoshanense 10%, American ginseng 15%, Ningxia wolfberry 10%, and lactose 65%. The production method of above-mentioned compound Herba Dendrobii granule comprises the following steps:

[0033] Step 1: Take Huoshan Dendrobium, American ginseng, and Ningxia wolfberry according to the weight ratio, sort and remove impurities, wash, spread to cool, crush, pass through a 10-mesh sieve, and wolfberry does not need to be crushed;

[0034] Step 2: Add 12 times the weight of water to Dendrobium Huoshanense and Ningxia Lycium barbarum, and cook three times in the cooking tank. 3.5h, 5.5h, 7h, the decoction extracts are filtered with a plate and frame filter press each time, the filtrates are combined, concentrated to a thick paste under neg...

Embodiment 2

[0040] The invention discloses a formula of compound Dendrobium Huoshanense granule, which comprises: Dendrobium Huoshanense, American ginseng, Ningxia wolfberry and lactose.

[0041] The weight percentages of each formula are respectively: 15% of Dendrobium Huoshanense, 20% of American ginseng, 15% of Ningxia wolfberry, and 50% of lactose. The production method of above-mentioned compound Herba Dendrobii granule comprises the following steps:

[0042] Step 1: Take Huoshan Dendrobium, American ginseng, and Ningxia wolfberry according to the weight ratio, sort and remove impurities, wash, spread to cool, crush, and pass through a 15-mesh sieve, and the wolfberry does not need to be crushed;

[0043] Step 2: Add 10 times the weight of water to Dendrobium Huoshanense and Ningxia Lycium barbarum, and cook three times in the cooking tank. The temperature and pressure of each cooking are: 118°C, 0.18Mpa, and the duration is 3h and 6h respectively. , 7.5h, each decoction extract was...

Embodiment 3

[0049] The invention discloses a formula of compound Dendrobium Huoshanense granule, which comprises: Dendrobium Huoshanense, American ginseng, Ningxia wolfberry and lactose.

[0050] The weight percentages of each formula are respectively: 20% of Dendrobium Huoshanense, 10% of American ginseng, 8% of Ningxia wolfberry, and 62% of lactose. The production method of above-mentioned compound Herba Dendrobii granule comprises the following steps:

[0051] Step 1: Take Huoshan Dendrobium, American ginseng, and Ningxia wolfberry according to the weight ratio, sort and remove impurities, wash, spread to cool, crush, and pass through a 20-mesh sieve, and the wolfberry does not need to be crushed;

[0052] Step 2: Add 15 times the weight of water to Dendrobium Huoshanense and Ningxia Lycium barbarum, and cook three times in a high-pressure stirring tank. The temperature and pressure of each cooking are: 120°C, 0.2Mpa, and the duration is 4 hours. , 5h, 8h. Each decoction liquid is fi...

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Abstract

The invention relates to a production method of compound dendrobium huoshanense granules. In the formula, the compound dendrobium huoshanense granules comprise the following components in percentage by weight: 10 to 20 percent of dendrobium huoshanense, 10 to 20 percent of American ginseng, 8 to 15 percent of Ningxia Chinese wolfberry and 45 to 72 percent of milk sugar. The invention also discloses a production method for the compound dendrobium huoshanense granules. The method comprises the following steps of: 1, picking the dendrobium huoshanense, the American ginseng and the Ningxia Chinese wolfberry, removing impurities, cleaning, spreading for cooling and crushing, wherein the Chinese wolfberry is not crushed; 2, adding the dendrobium huoshanense and the Ningxia Chinese wolfberry into water, detecting, and extracting for three times, filtering decocted and extracted liquid of every time, mixing the decocted and extracted liquid, concentrating under negative pressure to form thick paste, and removing filter dregs; 3, adding 70 percent ethanol into the American ginseng, detecting, and extracting for three times, filtering decocted and extracted liquid, mixing, and concentrating under the negative pressure to form thick paste; and 4, mixing extract obtained in the steps 2 and 3, concentrating further, and mixing the extract and the milk sugar in a weight ratio to prepare the granules. The compound dendrobium huoshanense granules have the advantages that: the reasonable and effective developing utilization of the dendrobium huoshanense serving as rare 'immortal grass' is realized, and the dissolution of active ingredients in the dendrobium huoshanense is improved, and thus, the compound dendrobium huoshanense granules are easy to take.

Description

【Technical field】 [0001] The invention relates to a traditional Chinese medicine health product, in particular to a formula and a production method of compound Huoshan Dendrobium granules. 【Background technique】 [0002] Dendrobium is a perennial herb of Orchidaceae. Huoshan Dendrobium is commonly known as "Middrobium", because it contains alkaloids, crude polysaccharides, amino acids, trace elements and other components that have the functions of strengthening kidney and essence, thickening stomach, inhibiting tumor cells, lowering blood sugar, enhancing Immunity, relieving physical fatigue and other effects have always been regarded as the first of the nine "immortal herbs". For a long time, due to the harsh growth conditions of Dendrobium Huoshanense and people's over-harvesting of it, this species has been on the verge of extinction. The applicant has realized species conservation and rational development and utilization of Dendrobium Huoshanense through modern biologic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61K9/16
Inventor 戴亚峰王新生陈锋
Owner JIUXIANZUN HUOSHAN DENDROBIUM CO LTD
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