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Kit for diagnosing lung cancer, determining prognosis, and improving patient survival

A kit, a technology for lung cancer, applied in the determination/examination of microorganisms, biochemical equipment and methods, gene therapy, etc., can solve the problem of inability to understand the molecular mechanism in detail

Active Publication Date: 2014-04-23
CAPITALBIO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although knowledge of the molecular biology of lung cancer has increased in recent years, a detailed understanding of the underlying molecular mechanisms remains

Method used

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  • Kit for diagnosing lung cancer, determining prognosis, and improving patient survival
  • Kit for diagnosing lung cancer, determining prognosis, and improving patient survival
  • Kit for diagnosing lung cancer, determining prognosis, and improving patient survival

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Embodiment Construction

[0024] This document is based, in part, on the study of genome-wide miRNA expression profiling using paired cryopreserved normal or cancerous lung tissue samples. Specifically, using DNA oligonucleotide microarrays, the expression of microRNAs in cancer samples was compared to the corresponding expression of miRNAs in non-cancer samples. Five microRNAs were identified as either overexpressed or overexpressed in tumor samples compared to corresponding non-cancer samples. Certain microRNAs were also identified as having altered levels in different disease states. Furthermore, levels of a miRNA were found and correlated with overall disease-free survival in lung cancer patients.

[0025] Accordingly, this document provides methods and components for assessing the diagnosis and prognosis of a disease (eg, cancer, eg, lung cancer) based on the status of the levels of microRNAs or the corresponding miRNA genes. On the one hand, there are methods and components provided to determin...

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Abstract

The methods and compositions diagnosing lung cancer, determining prognosis, and improving patient survival based on the levels or gene status of certain microRNAs, are provided.

Description

technical field [0001] The present invention relates to a method for diagnosing diseases based on microRNA (microRNA) expression (such as lung cancer), determining disease prognosis and improving patient survival. Background technique [0002] Lung cancer is the leading cause of cancer death in the world. Similar patients with lung cancer may have different clinical outcomes, and it is difficult to predict the prognosis of patients. [0003] Although knowledge of the molecular biology of lung cancer has increased in recent years, a detailed understanding of the underlying molecular mechanisms remains elusive. Clinically, accurate prognostic indicators are needed to identify high-risk patients, and the best treatment methods need to be designed specifically. [0004] All publications, patents, patent applications and patent application publications disclosed herein are hereby incorporated by reference. Contents of the invention [0005] The present invention is based in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68
CPCC12Q2600/178C12Q2600/112C12N2310/14C12N2320/50C12Q1/6886C12N2310/113C12N2310/141C12N15/113C12Q2600/118C12Q2600/136
Inventor 郭永谭晓刚张亮程京赫捷
Owner CAPITALBIO CORP