Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of magnolol or derivative thereof to preparation of antiepileptic medicaments

A technology of antiepileptic drugs and derivatives is applied in new medicinal purposes. In the field of preparing antiepileptic drugs, honokiol or its derivatives can solve the problems of limited drug application, difficulty in obtaining therapeutic effects, etc., and achieve good application. Prospect, less toxicity, less dependent effects

Inactive Publication Date: 2012-01-11
FUDAN UNIV
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drugs generally have side effects on the central nervous system, the blood system, and viscera, and the antiepileptic drugs such as diazepam also have the disadvantages of tolerance and addiction, which greatly limits the anti-epile

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of magnolol or derivative thereof to preparation of antiepileptic medicaments
  • Application of magnolol or derivative thereof to preparation of antiepileptic medicaments
  • Application of magnolol or derivative thereof to preparation of antiepileptic medicaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Experimental Materials

[0028] Male Kunming mice, SPF grade, 10-13 weeks old, 23-25g, were purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences. Breeding conditions: room temperature (22±1)°C, humidity (50±10)%, free access to water and food.

[0029] experimental method

[0030] Electrodes for recording electroencephalogram (EEG) were installed on the surface of the mouse skull, and the experiment was performed after the animal recovered for 10 days, and the electrode connecting wire was connected 3 days before the experiment. Administration groups are: vehicle (5% DMSO normal saline) control group, magnolol high, medium and low three dose groups, the doses are respectively: 80mg / kg, 40mg / kg and 20mg / kg, and the way of administration is intraperitoneal Administration by injection. Mouse EEG signals were recorded using Spike26.04 software (Cambridge, UK). The antiepileptic effect of magnolol was scientifically studied by combining the met...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of novel application of compounds and relates to application of magnolol or a derivative thereof to preparation of antiepileptic medicaments. The magnolol in the invention has the chemical name of 5', 5-diallyl-2, 2'-dihydroxybiphenyl and the chemical formula of C18H18O2 and the molecular weight of 266.32. Shown by results from animal experiments in the invention, high and medium dose of the magnolol can obviously decrease emission number of epileptiform waves, and the magnolol is demonstrated to decrease the emission of the epileptiform waves in a dose dependency manner; high and medium dose of the magnolol can obviously prolong the incubation period of myoclonic seizures and generalized seizures and obviously decrease the seizure level of epilepsy; and experiment results demonstrate that the magnolol or the derivative thereof have the characteristics of antiepileptic effect, low toxicity, and low habituation dependency and can be prepared into antiepileptic medicaments or health products.

Description

technical field [0001] The invention belongs to the technical field of new application of compounds, and relates to the new medical application of magnolol or its derivatives. In particular, it relates to the use of magnolol or its derivatives in the preparation of antiepileptic drugs. Background technique [0002] Epilepsy is a common chronic clinical syndrome with complex causes, characterized by brain dysfunction caused by repeated bursts of abnormal discharge of brain neurons. Epileptic seizures often cause abnormalities in the patient's movement, sensation, consciousness, spirit, autonomic nerve function, etc., and cause serious harm to human health. Clinical practice shows that if long-term epilepsy cannot be effectively controlled, it will lead to memory impairment, depression, physical and intellectual development retardation, low immune function, etc., and in severe cases, it will cause disability or death of the patient. According to the survey, the prevalence ra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/05A61P25/08A23L1/30
Inventor 黄志力陈长瑞曲卫敏
Owner FUDAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com