Injecta for treating bacterial encephalitis of dog and preparation method thereof

An injection and a bacterial technology, applied in the field of injections for the treatment of canine bacterial encephalitis, can solve problems such as untimely treatment, loss of breeders, inability to treat, etc., achieve simple preparation methods, reduce allergic reactions, and strengthen antibacterial effects Effect

Inactive Publication Date: 2012-01-25
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, due to the complexity of canine bacterial encephalitis, many drugs cannot pass through the blood-brain barrier and cannot be treated, and drugs that...

Method used

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  • Injecta for treating bacterial encephalitis of dog and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Take 30L of water for injection, add 15kg of sulfadiazine sodium, stir to dissolve, then add 10kg of analgin, stir to dissolve.

[0021] (2) Take 10kg of dimethylformamide and 20kg of propylene glycol and heat it to about 60°C, dissolve 3kg of trimethoprim and 0.1kg of chlorpheniramine maleate, then add 10kg of propylene glycol and 10kg of 95% ethanol, and stir well .

[0022] (3) Combine the solution of step (1) and step (2), add water for injection to 100L, adjust the pH value to 10.5 with the sodium hydroxide solution of 10% with the mass percentage concentration or the hydrochloric acid solution with the mass percentage concentration of 10% -11.0, stand still for 15 minutes, and get the injection for treating canine bacterial encephalitis after the liquid is clarified.

Embodiment 2

[0024] (1) Take 30L of water for injection, add 5kg of sulfadiazine sodium, stir to dissolve, then add 20kg of analgin, stir to dissolve.

[0025] (2) Take 10kg of dimethylformamide and 20kg of propylene glycol and heat it to about 60°C, dissolve 1kg of trimethoprim and 0.2kg of chlorpheniramine maleate, after dissolving, add 10kg of propylene glycol and 10kg of 95% ethanol, and stir well .

[0026] (3) Combine the solution of step (1) and step (2), add water for injection to 100L, adjust the pH value to 10.5 with the sodium hydroxide solution of 10% with the mass percentage concentration or the hydrochloric acid solution with the mass percentage concentration of 10% -11.0, leave standstill for 15 minutes, and get the injection that is used for the treatment of canine bacterial encephalitis after the liquid is clarified.

Embodiment 3

[0028] (1) Take 30L of water for injection, add 12kg of sulfadiazine sodium, stir to dissolve, then add 12kg of analgin, stir to dissolve.

[0029] (2) Take 10kg of dimethylformamide and 20kg of propylene glycol and heat it to about 60°C, dissolve 2.4kg of trimethoprim and 0.12kg of chlorpheniramine maleate, after dissolving, add 10kg of propylene glycol and 10kg of 95% ethanol, and stir uniform.

[0030] (3) Combine the solution of step (1) and step (2), add water for injection to 100L, adjust the pH value to 10.5 with the sodium hydroxide solution of 10% with the mass percentage concentration or the hydrochloric acid solution with the mass percentage concentration of 10% -11.0, leave standstill for 15 minutes, and get the injection that is used for the treatment of canine bacterial encephalitis after the liquid is clarified.

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PUM

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Abstract

The invention discloses injecta for treating bacterial encephalitis of a dog and a preparation method thereof, and aims at providing the injecta for treating bacterial encephalitis of the dog effectively and efficiently, with an effect for treating both principal and secondary aspect of the disease as well as the preparation method with a simple process and easiness in realization. Every 100L of injecta comprises 5-15kg of sulfadiazine sodium, 10-20kg of analgin, 1-3kg of trimethoprim, 0.1-0.2kg of chlorphenamine, 10kg of dimethylformamide, 10kg of 95 percent ethanol, 30kg of propanediol and the balance of water for injection. The sulfadiazine sodium adopted by the invention has a wide spectrum antimicrobial function and can be used for transmitting through a blood brain barrier and killing bacteria; the trimethoprim is a synergistic agent and can be used for enhancing the antimicrobial effect of the sulfadiazine sodium and changing the traditional bacteriostatic action into bactericidal action; the analgin has functions of defervescing and resisting inflammation and can be used for reducing the damage to an immunologic system and nerve of the dog caused by high fever; and the chlorphenamine has the functions of resisting hypersusceptibility and calming and can be used for reducing an anaphylactic reaction caused by toxin generated by bacteria.

Description

technical field [0001] The invention relates to an injection for treating canine bacterial encephalitis and a preparation method thereof. Background technique [0002] Canine bacterial encephalitis is a febrile disease, and the infection site is mainly in the brain. The main clinical manifestation is that the dog’s body temperature rises above 40°C. When the inflammatory focus is far away from the cerebral cortex and the scope is small, the clinical manifestations shown Symptoms are mild, with disturbance of consciousness as the most prominent. The sick dog may be excited or highly depressed, and even does not know the owner. When the inflammation develops to the deep part of the brain or there are inflammatory lesions in the deep part of the brain, it can cause generalized or incomplete paralysis, movement disorders of the limbs, ptosis, dilated pupils, paralysis of the optic nerve, masseter muscle, pharyngeal muscle, larynx and tongue, lying down Immobility, complete loss...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K31/505A61K31/4402A61K31/4152A61K9/08A61P31/04A61P29/00A61P37/08A61P25/20
Inventor 徐克福
Owner TIANJIN SHENGJI GRP CO LTD
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