Clindamycin phosphate vaginal mucosa tablet and preparation method thereof

A technology of clindamycin phosphate and mucous membrane tablets, applied in the field of clindamycin phosphate preparation and preparation thereof, and antifungal pharmaceutical preparations, can solve the problem of low bioavailability, low safety and large adverse reactions and other problems, to achieve the effect of good antibacterial effect, maintaining blood concentration and fast onset of action

Active Publication Date: 2012-02-01
HANGZHOU SHARPLY PHARM R&D INSTIT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Clindamycin preparations currently on the market are mainly injections. Clindamycin injections are directly injected into the blood, which has relatively large adverse reactions, is not safe enough, and cannot directly target the lesion, so the onset of action is slow , low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: prepare 1000 prescriptions:

[0019] Clindamycin Phosphate 100g Microcrystalline Cellulose (MCC) 200g

[0020] Citric acid 100g Sodium bicarbonate 200g

[0021] HPMC K4M 80g Carbopol 934p 190g

[0022] Magnesium Stearate 20g Silicon Dioxide 40g

[0023] Preparation:

[0024] Mix clindamycin phosphate, MCC, citric acid, HPMC K4M, and Carbopol 934p through a 100-mesh sieve evenly, moisten with 70% ethanol solution, granulate with a 20-mesh sieve after spraying and wetting, and pass through a 18-mesh sieve after drying Granules, then add the rest of the spreading material and mix evenly, then press into tablets.

[0025] The clindamycin phosphate vaginal mucosa tablet prepared in this example has good antibacterial effect, and is directly aimed at the affected area, with quick onset and high bioavailability, and effervescent agent and slow-release material are added in the tablet, so that this The inventive tablet can maintain an effective blood drug con...

Embodiment 2

[0026] Embodiment 2: prepare 1000 prescriptions:

[0027] Clindamycin Phosphate 120g Lactose 250g

[0028] Citric acid 100g Sodium bicarbonate 200g

[0029] Ethylcellulose 100g Carbopol 934p 150g

[0030] Magnesium Stearate 15g Silicon Dioxide 35g

[0031] The preparation process is the same as in Example 1.

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PUM

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Abstract

The invention relates to a clindamycin phosphate vaginal mucosa tablet and a preparation method thereof. The clindamycin phosphate vaginal mucosa tablet disclosed by the invention comprises clindamycin phosphate, a filling agent, an effervescing agent and a slow-release material, has the advantages of very good antibacterial effect, fast effect-taking and high bioavailability, and can be directly applied specific to a wound. In addition, the effervescing agent and the slow-release material are added in the tablet, so that the tablet can be used for maintaining effective plasma concentration at the same time of rapidly exerting a curative effect, and the clindamycin phosphate vaginal mucosa tablet has a longer endurance time.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to an antifungal pharmaceutical preparation, in particular to a clindamycin phosphate preparation and a preparation method thereof. Background technique [0002] Clindamycin was synthesized for the first time in 1966 by Magerlerin et al. who replaced the 7th hydroxyl group in the lincomycin molecule with chlorine. Compared with lincomycin, the antibacterial activity of clindamycin was enhanced by 4 to 8 times, and adverse reactions Low. Clindamycin Phosphate is a semi-synthetic derivative of lincomycin. It is a spectrum antibiotic that acts on both anaerobic and aerobic bacteria. It has no antibacterial activity in vitro and is rapidly hydrolyzed into clindamycin after entering the human body. And the reality of its pharmacological activity. It mainly has strong antibacterial activity against Gram-positive cocci and anaerobic bacteria, and is used to treat various infectious diseases...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/46A61K31/7056A61P31/04A61P31/02
Inventor 范敏华姜双瑜刘华
Owner HANGZHOU SHARPLY PHARM R&D INSTIT
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