Clindamycin phosphate vaginal mucosa tablet and preparation method thereof
A technology of clindamycin phosphate and mucous membrane tablets, applied in the field of clindamycin phosphate preparation and preparation thereof, and antifungal pharmaceutical preparations, can solve the problem of low bioavailability, low safety and large adverse reactions and other problems, to achieve the effect of good antibacterial effect, maintaining blood concentration and fast onset of action
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Embodiment 1
[0018] Embodiment 1: prepare 1000 prescriptions:
[0019] Clindamycin Phosphate 100g Microcrystalline Cellulose (MCC) 200g
[0020] Citric acid 100g Sodium bicarbonate 200g
[0021] HPMC K4M 80g Carbopol 934p 190g
[0022] Magnesium Stearate 20g Silicon Dioxide 40g
[0023] Preparation:
[0024] Mix clindamycin phosphate, MCC, citric acid, HPMC K4M, and Carbopol 934p through a 100-mesh sieve evenly, moisten with 70% ethanol solution, granulate with a 20-mesh sieve after spraying and wetting, and pass through a 18-mesh sieve after drying Granules, then add the rest of the spreading material and mix evenly, then press into tablets.
[0025] The clindamycin phosphate vaginal mucosa tablet prepared in this example has good antibacterial effect, and is directly aimed at the affected area, with quick onset and high bioavailability, and effervescent agent and slow-release material are added in the tablet, so that this The inventive tablet can maintain an effective blood drug con...
Embodiment 2
[0026] Embodiment 2: prepare 1000 prescriptions:
[0027] Clindamycin Phosphate 120g Lactose 250g
[0028] Citric acid 100g Sodium bicarbonate 200g
[0029] Ethylcellulose 100g Carbopol 934p 150g
[0030] Magnesium Stearate 15g Silicon Dioxide 35g
[0031] The preparation process is the same as in Example 1.
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