Purification and preparation method for aescin extract

A technique for aescin and extract, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of long time consumption, many process steps, large environmental pollution and the like

Inactive Publication Date: 2012-02-01
南京星银药业集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

All kinds of extraction methods need to consume a large amount of organic solvents, the recovery of solvents requires high energy consumption, great environmental pollution, many process steps, long time consumption and high cost
Among them, the chloroform extraction method is relatively simple, and the purity of the finished product is high, but chloroform is very harmful to the human body and the environment. heavily used in production

Method used

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  • Purification and preparation method for aescin extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Weigh the aescin extract prepared by reflux extraction with ethanol aqueous solution, add 1 times the amount of deionized water and stir to dissolve, adjust the pH value to 2.1 with hydrochloric acid solution, add 1 times the amount of n-butanol for extraction, and repeat the extraction once , combine the extracts, wash with 2% sodium carbonate aqueous solution until neutral, recover the solvent under reduced pressure, process the obtained aescin with microwave irradiation, adjust the microwave power so that the temperature of the material is controlled at 40-50°C, and irradiate for 130 minutes. The powdery off-white aescin is obtained, and the package is sealed. Weigh the weight of aescin, calculate the yield of purification and preparation; use high performance liquid chromatography to measure the content of aescin standard substance as a control, and use the area normalization method to calculate the total content of aescin A, B, C, D ; Determination of wat...

Embodiment 2

[0014] Example 2 Weigh the aescin extract prepared by microwave extraction technology (Chinese Invention Patent Application No. 201010221513.7), add 1 times the amount of deionized water and stir to dissolve, adjust the pH value to 2.2 with hydrochloric acid solution, add 1 times the amount of n-butyl Alcohol extraction twice, combined extracts, washed with 2% sodium carbonate aqueous solution until neutral, and recovered solvent under reduced pressure, the obtained aescin was treated with microwave irradiation, and the microwave power was adjusted to control the temperature of the material at 40-50°C. According to 120 minutes, get powdery off-white aescin, package and seal. Weigh the weight of aescin, calculate the yield of purification and preparation; use high performance liquid chromatography to measure the content of aescin standard substance as a control, and use the area normalization method to calculate the total content of aescin A, B, C, D ; Determination of water co...

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Abstract

The invention provides a simple purification and preparation method for an aescin extract. The method comprises the steps of: adding water to the aescin extract for dissolution, adjusting the pH value to 1-4 with an acid solution, conducting extraction with n-butanol for two times, washing the extracting solution to neutral with lye, recovering the solvent and drying it by microwave irradiation, packaging and sealing the solvent, thus obtaining a raw material of the effective part of aescin and in accord with medicinal purity requirements. The method provided in the invention has the advantages of simple process, high efficiency, as well as environmental protection and energy saving.

Description

technical field [0001] The invention belongs to the field of preparation of active ingredients of traditional Chinese medicines, and in particular relates to a method for purifying and preparing aescin extract. Background technique [0002] Aescin is a mixture containing more than 30 kinds of saponins extracted and separated from the Chinese herbal medicine Suluozi. It belongs to the triterpenoid saponins, and aescin A, B, C, and D are medicinal effective parts. Salazi is derived from the dry mature seeds of Aesculus chinensis Bge., Aesculus chinensis.Bge.var.Chekiangensis(Hu et Fang) Fang or Aesculus Wilsonii Rehd., which are sweet in nature and sweet in taste. , warm, return liver, stomach meridian, its function and indications are soothing the liver and regulating qi, harmonizing the stomach and relieving pain, used for stagnation of liver and stomach qi, chest and abdomen distension, epigastric pain Page]. Aescin is the most important active ingredient of the tradition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00C07H15/256C07H1/08
Inventor 刘庭福刘利根钟元元
Owner 南京星银药业集团有限公司
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