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Composition for preventing or treating diseases caused by arteriosclerosis

An arteriosclerosis and composition technology, which is applied in the fields of drug combination, cardiovascular system diseases, plant raw materials, etc., can solve the problems that no one has explored the anti-arteriosclerosis effect of Sanhuang Xiexin Decoction

Active Publication Date: 2013-11-06
KAOHSIUNG MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although the above-mentioned anti-inflammatory effect of Sanhuang Xiexin Decoction has been discovered, no one has yet explored the anti-arteriosclerosis effect of Sanhuang Xiexin Decoction

Method used

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  • Composition for preventing or treating diseases caused by arteriosclerosis
  • Composition for preventing or treating diseases caused by arteriosclerosis
  • Composition for preventing or treating diseases caused by arteriosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Materials and methods:

[0033] 1. Preparation of Sanhuang Xiexin Decoction

[0034] The Sanhuang Xiexin Decoction used in the following experiments was manufactured by Zhuang Songrong Pharmaceutical Factory in Taiwan. The crude drug powders of the rhizome of rhubarb, the root of Scutellaria baicalensis and the rhizome of Coptidis rhizome were weighed in a ratio of 2:1:1 (360.0 g:180.0 g:180.0 g). Each medicinal material is added with 10 times the volume of water and boiled. After the extraction was complete, it was filtered to yield three extraction solutions. The three hot solutions are combined and then concentrated to only 1 / 20 of the total volume of water in which the three herbs were originally added. The newly formed concentrated solution was spray dried to give 200.2 g of the extract as a dry powder. The production and quality control of raw materials and authorized products are inspected in accordance with the Chinese Pharmacopoeia and guidelines.

[0035]...

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PUM

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Abstract

The invention provides a composition for preventing or treating diseases caused by arteriosclerosis. The composition comprises rhubarb, baikal skullcap root and coptis root. In the terms of the weights of dry medicinal materials, the ratio of the rhubarb to the baikal skullcap root to the coptis root is (1-3):(0.5-1.5):(0.5-1.5).

Description

technical field [0001] The present invention relates to a composition for preventing or treating diseases caused by arteriosclerosis. Background technique [0002] Arteriosclerosis is a major cause of cardiovascular and cerebrovascular diseases, which are the leading cause of mortality in industrialized countries. Atherosclerosis is a progressive process involving multiple factors such as several mediators and information pathways, including ERK 1 / 2 signaling (Millette E, Rauch BH, Defawe 0, Kenagy RD, Daum G, Clowes AW. Platelet-derived growth Factor-bb-induced human smooth muscle cell proli fermentation depends on basic fgf release and fgfr-1 activation. Circ Res 2005;96:172-179; Abraham ST, Benscoter HA, Schworer CM, Singer HA. A role for ca 2+ / calmodulin-dependent protein kinase ii in the mitogen-activated protein kinase signaling cascade of cultured rat aortic vascular smooth muscle cells. Circ Res 1997; 81: 575-584; Libby P, Aikawa M. Stabilization of atherosclerotic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P9/10
Inventor 卓夙航王永松郑欣芸
Owner KAOHSIUNG MEDICAL UNIVERSITY