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Preparation method of montmorillonite preparations

A montmorillonite and preparation technology, which is applied in the field of preparation of montmorillonite preparations, can solve the problems of collapse of montmorillonite lamella structure, non-identical rehydration structures, inability to rehydrate and restore, etc.

Inactive Publication Date: 2013-03-27
JINAN KANGZHONG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At a temperature of 105°C, a considerable amount of interlayer adsorbed water escapes from montmorillonite. At this time, most of the dehydrated products can be rehydrated, but the rehydrated products are not exactly the same as the original structure; The "collapse" of the montmorillonite layer structure cannot be restored by rehydration
If the montmorillonite raw material used in the montmorillonite preparation has only an upper limit and no lower limit, it may cause the montmorillonite to be too dry, resulting in the escape of water between the montmorillonite layers, resulting in the destruction of the montmorillonite layer structure, thereby affecting the curative effect

Method used

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  • Preparation method of montmorillonite preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1 tests the raw material montmorillonite used in the present invention,

[0072] Test conditions (according to the third method of Appendix IV E of the Chinese Pharmacopoeia 2010 Edition): laser particle size analyzer, instrument model Winner2000ZD; sample pretreatment, none; dispersion type, wet dispersion; ultrasonic, ultrasonic 60s; stirring speed, 300 rpm; software version; V1.0; lens focal length, 50; optical density, 1.0-2.5; light scattering model used, Mie scattering; complex refractive index, real part 1.51, imaginary part 0.01; Combined parameters, squared difference. The results are as follows:

[0073] The raw material drug montmorillonite test report used in the present invention

[0074]

[0075] Judgment: The result complies with the regulations

Embodiment 2

[0077] Prepare montmorillonite powder with the qualified montmorillonite raw material tested in Example 1, weigh 300g of montmorillonite, 74.9g of glucose, 0.7g of sodium saccharin, and 0.4g of vanillin, fully mix, and pack into each bag containing montmorillonite. Stone 3g powder.

Embodiment 3

[0079] Prepare montmorillonite suspension with the qualified montmorillonite raw material tested in Example 1, take by weighing montmorillonite 300g, glucose 74.9g, sodium saccharin 0.7g, vanillin 0.4g, sodium benzoate 0.5g, add water to 3000ml, fully Stir evenly to obtain a 10% montmorillonite suspension.

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Abstract

The invention relates to a preparation method of montmorillonite preparations, which is characterized in that the sum of any two impurity peak intensities in the X-ray powder diffraction pattern of adopted montmorillonite is not higher than the second characteristic peak of the montmorillonite; the drying loss is between 5 percent and 10.0 percent; the average grain diameter or the middle position diameter is not greater than 15 mum, the accumulated percentage of grains with the grain diameter smaller than 35 mum is not lower than 90 percent, and the specific surface area is not smaller than 8000 cm<2> / cm<3>; the absorption force is measured by a cation exchange volume method, and the cation exchange volume is 70 to 150 mmol / 100g; and the silicon dioxide content is 55 percent to 65 percent, and the aluminum oxide content is 12 percent to 25 percent. The montmorillonite preparations have the advantages of high safety and good curative effect. Compared with the montmorillonite preparations on the market, the montmorillonite preparations have the controllable quality.

Description

field of invention [0001] The invention relates to a preparation method of a montmorillonite preparation, which belongs to the technical field of medicines. Background technique [0002] The montmorillonite preparation has been proved by many years of clinical practice to be effective in the treatment of diarrheal diseases, with little toxic and side effects. However, the quality of montmorillonite preparations sold in the market is on the low side, and the best curative effect cannot be guaranteed. Tracing it to its cause is that the quality of raw materials used for preparing montmorillonite medicine is on the low side. [0003] For the montmorillonite preparations sold on the market, the X-ray powder diffraction spectrum of the montmorillonite raw material used in the preparation method stipulates: "The characteristic spectral lines of the montmorillonite are at about 1.5nm and 0.45nm, and the intensity of other impurity peaks in the spectrum must not It is higher than ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/06A61P1/12
Inventor 张为胜李诗标许翠萍周长征牛凤菊苑学明
Owner JINAN KANGZHONG PHARMA TECH DEV