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Medicinal inhalation devices and components thereof

A technology for inhalation devices and medicines, which can be used in inhalers, medicine devices, and devices for coating liquids on surfaces, etc., and can solve problems such as operation effects.

Inactive Publication Date: 2012-05-16
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For DPI, the penetration and adsorption of surrounding water often cause problems
Additionally, the use of materials with relatively high surface energies for certain components (e.g., the metered dose valve and / or individual components thereof) may have an undesired effect on the operation of the movable parts of the pharmaceutical inhalation device

Method used

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  • Medicinal inhalation devices and components thereof
  • Medicinal inhalation devices and components thereof
  • Medicinal inhalation devices and components thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1 to example 13

[0294] In the following set of examples, the redispersion of albuterol sulphate deposited & dried on the inner surface of the container was examined using the following method (thus enabling examination of the deposition / container surface properties of albuterol sulphate):

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PUM

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Abstract

A composition for modifying a surface of a substrate, the composition comprising: (a) a first polyfluoropolyether silane of the Formula Ia: CF3CF2CF2O(CF(CF3)CF2O)pCF(CF3)-C(O)NH(CH2)3Si(Y)3 wherein each Y is independently a hydrolyzable group and wherein p is 3 to 50; and (b) a second polyfluoropolyether silane of the Formula IIa: (Y')3Si(CH2)3NHC(O)-CF2O(CF2O)m(C2F4O)qCF2-C(O)NH(CH2)3Si(Y')3 wherein each Y' is independently a hydrolyzable group and wherein m is 1 to 50 and q is 3 to 40. A method of making a medicinal inhalation device or a component of a medicinal inhalation device comprising a step of applying to at least a portion of a surface of the device or the component, respectively, the composition.

Description

technical field [0001] The present invention relates to medicinal inhalation devices and components of such devices, and methods of making such devices and components. The present invention also relates to compositions for modifying surfaces and articles, including substrates coated by applying the compositions. Background technique [0002] Drug inhalation devices are widely used for the delivery of drugs, including pressurized inhalers such as metered dose inhalers (MDI) and dry powder inhalers (DPI). [0003] Drug inhalation devices typically consist of multiple hardware components, (in the case of an MDI, it may include gasket seals; metered dose valves (including their respective components such as sleeves, valve body, stem, groove, spring, retaining cup, and seal parts); container and actuator) and various interior surfaces that come into contact with the drug formulation during storage or during delivery. Often, an ideal material for a particular component is found ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B05D5/08C07F7/18
CPCC08G65/336A61M15/00B05D3/142C08G65/007C08G77/46C08G77/24C09D183/12B05D2350/63B65D83/38A61M2205/0238B05D1/34A61M2202/064B05D5/083A61M15/009A61M2205/0222A61M2205/02
Inventor 苏赖斯·艾耶尔莫塞斯·M·大卫简·A·凯利菲利浦·A·因克斯克里斯托弗·G·布拉奇福德
Owner 3M INNOVATIVE PROPERTIES CO