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Thermoacoustic system for analyzing tissue

A soft tissue, vasculature technology, used in applications, sonic diagnosis, infrasound diagnosis, etc.

Active Publication Date: 2012-05-30
ENDRA LIFE SCI INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method suffers from many of the same disadvantages as X-ray computed tomography perfusion measurements

Method used

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  • Thermoacoustic system for analyzing tissue
  • Thermoacoustic system for analyzing tissue
  • Thermoacoustic system for analyzing tissue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Example 1. In vitro experiments demonstrating the thermoacoustic approach

[0085] Experiments were performed in vitro to demonstrate the provided thermoacoustic method using a variety of contrast agents. In each experiment, an appropriate contrast agent was placed in a 2-mm tube surrounded by a second aqueous solution and irradiated with pulsed radiofrequency energy, and the resulting thermoacoustic data ( Figure 5 ). Data showed positive (ie increased thermoacoustic signal) and negative (ie decreased thermoacoustic signal) depending on the contrast agent and surrounding medium used in each experiment. Figure 5 The upper left panel of , shows increased signal due to increased ion concentration and thus conductivity and energy absorption in a 2-mm tube of 0.9% saline relative to surrounding deionized water. Figure 5 The upper right panel of , shows the increased signal resulting from irradiation of a 2-mm tube containing 2% saline in an environment of 0.9% saline. ...

Embodiment 2

[0087] Example 2. Spatial resolution of data provided by thermoacoustic methods

[0088] In vitro experiments were performed to determine the spatial resolution of the data provided by the thermoacoustic method. In this experiment, four 0.3-mm tubes containing 5X normal saline (5% NaCl) were placed in a saline environment, the tubes were irradiated with pulsed radiofrequency energy, and the resulting thermoacoustic data ( Figure 6 ) show that thermoacoustic methods can detect deep submillimeter structures with very high contrast.

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Abstract

The invention provides methods and systems to analyze soft tissue or vasculature in a subject, form images with enhanced soft tissue contrast, determine blood flow parameters in soft tissue or vasculature, and to aid in the diagnosis of disease using thermoacoustic methods. Pulsed electromagnetic energy is administered to tissue to excite a thermoacoustic signal in the soft tissue or vasculature. An acoustic receiver or receiver array is coupled to a subject to detect and record the thermoacoustic signals produced. Thermoacoustic data are acquired after administration of a physiologically-tolerable tracer or contrast agent. The acquired data may be analyzed to produce images of the soft tissue and vasculature (angiogram), to determine blood flow parameters, and / or to diagnose disease in a subject.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application No. 61 / 179,467, filed May 19, 2009, which is incorporated herein by reference. Background of the invention [0003] In general, the systems and methods described herein relate to analyzing and visualizing soft tissue and vasculature in a subject, calculating blood flow parameters in tissue, and diagnosing, evaluating, and monitoring disease using thermoacoustic methods. [0004] Vascular morphology and tissue perfusion can indicate the health status of an organ and can be used to diagnose disease and monitor treatment. Measurement of blood flow in tissue can be used to diagnose a variety of diseases or disease states, including kidney disease, cardiovascular disease, stroke, and cancer. [0005] Thermoacoustic imaging uses short bursts of electromagnetic energy to rapidly heat absorbing components within an object, which in turn produces sound pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/05
CPCA61B5/0059A61B5/026A61B5/0095A61B5/415A61B8/4272
Inventor 保罗·A·皮科特迈克尔·M·桑顿大卫·A·斯坦伯格
Owner ENDRA LIFE SCI INC
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