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Rifaximin vaginal suppository for livestock and preparation method for same

A technology of rifaximin and vaginal suppository, which is applied in the field of rifaximin vaginal suppository for livestock and its preparation, can solve the problems of rifaximin difficulty, influence on antibacterial effect, disintegration time limit and dissolution timeout, etc., and achieve optimal Melting time limit, strong antibacterial effect, overcoming the effect of long melting time limit

Active Publication Date: 2012-06-27
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rifaximin is insoluble in water. When conventional methods are used to prepare suppositories, the disintegration time limit and dissolution are often overtime, which affects its antibacterial effect.

Method used

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  • Rifaximin vaginal suppository for livestock and preparation method for same
  • Rifaximin vaginal suppository for livestock and preparation method for same
  • Rifaximin vaginal suppository for livestock and preparation method for same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Rifaximin solid dispersion preparation

[0028] prescription:

[0029]

[0030] Weigh PEG1000 and PEG4000 according to the prescription content, melt in a water bath at 70°C-80°C, add rifaximin solution that has been dissolved in 8.0g of absolute ethanol, stir well, evaporate the ethanol in a water bath at 70°C-80°C, and then cool down rapidly Cool and solidify to obtain the solid dispersion of rifaximin.

Embodiment 2

[0032] Rifaximin solid dispersion preparation

[0033] prescription:

[0034]

[0035]Weigh PEG1000 and Poloxamer F68 according to the prescription content, melt in a water bath at 70°C-80°C, add rifaximin solution that has been dissolved in 8.0g of absolute ethanol, stir well, evaporate the ethanol in a water bath at 70°C-80°C Afterwards, the temperature is rapidly lowered and cooled to solidify, and the solid dispersion of rifaximin is obtained.

Embodiment 3

[0037] Rifaximin solid dispersion preparation

[0038] prescription:

[0039]

[0040] Weigh PEG4000 and poloxamer F68 according to the prescription content, melt in a water bath at 70°C-80°C, add rifaximin solution that has been dissolved in 8.0g of absolute ethanol, stir well, evaporate the ethanol in a water bath at 70°C-80°C Afterwards, the temperature is rapidly lowered and cooled to solidify, and the solid dispersion of rifaximin is obtained.

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PUM

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Abstract

The invention belongs to the field of veterinary medicine, and particularly relates to a rifaximin vaginal suppository for livestock and a preparation method for the same. The suppository contains the following components: 8.5-25.5 parts by weight of rifaximin solid dispersion, 30-88 parts by weight of matrix, 6.0-12.5 parts by weight of water, 0.01-1.0 parts by weight of surfactant, 0.01-10.0 parts by weight of synergist and 0.01-5.0 parts by weight of preservative, wherein the rifaximin solid dispersion is obtained by melting 7.3-21.9 parts by weight of solid dispersion carrier in a water bath at 70-80 DEG C, and then adding the used 2-16 parts by weight of absolute ethyl alcohol to dissolve 1.2-3.6 parts by weight of rifaximin to obtain rifaximin solution, uniformly stirring, steaming away the absolute ethyl alcohol in the water bath at 70-80 DEG C, and then rapidly cooling and solidifying. The suppository disclosed by the invention can ensure the uniform dispersion of main medicine and overcome the problems of low heat resistance and long melting time limit of glycerin gelatine matrix.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a rifaximin vaginal suppository for livestock and a preparation method thereof. Background technique [0002] Rifaximin (Rifaximin) is a semi-synthetic derivative of rifamycin SV, which is a broad-spectrum, high-efficiency, low-toxic intestinal or topical antibiotic. The drug was developed by the Italian Alpha Company. It was first launched in Italy in 1987 as an anti-infective diarrhea drug, and then widely used in Europe and the United States. In 2004, it was approved by the SFDA for clinical application in my country, mainly for the prevention and treatment of sensitive bacteria. Acute and chronic intestinal infections caused by It has been reported that the marketed dosage forms include dry suspension, capsules, tablets, granules, etc. for oral administration. [0003] Rifaximin has a broad antibacterial spectrum and strong antibacterial activity. For Gram-positive aerobic ...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/437A61P15/00A61P31/04
Inventor 余祖功李晶张海彬张军忍江善祥
Owner ZHENGZHOU BARY ANIMAL PHARMA
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