Sultamicittin composition and preparation method thereof
A technology for sutacillin and composition, which is applied in the field of sutacillin composition and its preparation, can solve the problems of no tablet stability data, no sutacillin tablet, etc., and is suitable for wide popularization and application and easy to operate. , the effect of fast disintegration
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Embodiment 1
[0031] A sultacillin composition, comprising the following components by weight: 73.53 parts of sultacillin (particle size: 100-150 μm), 2.64 parts of crospovidone, 7.35 parts of croscarmellose sodium, poly 7.35 parts of vitamin ketone, 7.35 parts of lactose, 0.74 parts of magnesium stearate, 0.37 parts of steviol glycosides, and 0.37 parts of strawberry powder essence.
[0032] The preparation method of above-mentioned sultacillin composition, comprises the following steps:
[0033] 1) After drying the raw materials except sultacillin to a water content of ≤1%, mix them with sultacillin in a mixer for 30 minutes to obtain a mixture;
[0034] 2) The mixture is made into 40 mesh granules with a dry granulator;
[0035] 3) Put the granules in a tablet machine and compress into tablets with a tablet weight of 0.323-0.357g / tablet to obtain sultacillin tablets.
Embodiment 2
[0037] A sultacillin composition, comprising the following components by weight: 55.37 parts of sultacillin (with a particle size of 180-200 μm), 9.97 parts of crospovidone, 5.54 parts of povidone, and 13.84 parts of microcrystalline cellulose , 3 parts of lactose, 0.55 parts of magnesium stearate, 0.3 parts of steviol glycosides, 0.2 parts of aspartame, 0.5 parts of strawberry powder flavor.
[0038] The preparation method of above-mentioned sultacillin composition, comprises the following steps:
[0039] 1) After drying the raw materials except sultacillin to a water content of ≤1%, mix them with sultacillin in a mixer for 30 minutes to obtain a mixture;
[0040] 2) Place the mixture in a tablet press, press the tablet with a die with a diameter of 25mm, and then crush it into 50 mesh particles;
[0041] 3) Divide the granules into aluminum bags with a loading range of 0.429 to 0.474g / bag to make sultacillin granules.
Embodiment 3
[0043] A sultacillin composition, comprising the following components by weight: 45 parts of sultacillin (particle size: 25-80 μm), 7 parts of crospovidone, 7 parts of croscarmellose sodium, lactose 27.45 parts, 8.55 parts of mannitol, 7.32 parts of povidone, 0.4 parts of magnesium stearate, 0.2 parts of aspartame, and 0.2 parts of apple powder essence.
[0044] The preparation method of above-mentioned sultacillin composition, comprises the following steps:
[0045] 1) After drying the raw materials except sultacillin to a water content of ≤1%, mix them with sultacillin in a mixer for 30 minutes to obtain a mixture;
[0046] 2) Place the mixture in a tablet press, press the tablet with a die with a diameter of 25mm, and then crush it into 80 mesh particles;
[0047] 3) Divide the granules into aluminum bags with a filling volume ranging from 0.519 to 0.573 g to make sultacillin granules.
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