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Voriconazole ear drop and preparation method and application thereof

A technology of voriconazole and ear drops, applied in the field of voriconazole ear drops and preparation thereof, can solve the problems of no compound patent for voriconazole, no patent for ear drops preparation and method, etc., and achieves improvement of ear pain, high compliance, Remove the effect of the restore function

Active Publication Date: 2014-07-23
LIVZON GROUP LIVZON PHARMA FACTORY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Voriconazole has no compound patents in China, and no patents on preparations and methods for ear drops have been seen

Method used

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  • Voriconazole ear drop and preparation method and application thereof
  • Voriconazole ear drop and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This example is used to illustrate the ear drops provided by the present invention and its preparation method.

[0034] prescription:

[0035] Voriconazole 0.5g 0.5% by weight

[0036] Ambroxol hydrochloride 2g 2% by weight

[0037] Carbomer 1g 1% by weight

[0038] Glycerin 10g 10% by weight

[0039] Propylene glycol 9g 9% by weight

[0040] Polyethylene glycol 15 hydroxy fatty acid ester 2g 2% by weight

[0041] Phosphatidylethanolamine 1g 1% by weight

[0042] Triethanolamine 1.35g 1.35% by weight

[0043] Glacial acetic acid 1g 1% by weight

[0044] 95% ethanol 20g 20% ​​by weight

[0045] Distilled water was added to 100 g 50.15% by weight.

[0046] According to the above prescription, take carbomer and fully swell in an appropriate amount of distilled water, add glycerin and stir evenly, then add triethanolamine dropwise, and stir to obtain a transparent gel matrix. Add voriconazole and ambroxol hydrochloride with 95% ethanol and propylene glycol to diss...

Embodiment 2

[0048] This example is used to illustrate the ear drops provided by the present invention and its preparation method.

[0049] prescription:

[0050] Voriconazole 0.5g 0.5% by weight

[0051] Ambroxol hydrochloride 2g 2% by weight

[0052] Propylene glycol 10g 10% by weight

[0053] Glycerin 6g 6.0% by weight

[0054] Poloxamer 1.24g 1.24% by weight

[0055] Lecithin 5.0g 5.0% by weight

[0056] LGP 0.12g 0.12% by weight

[0057] Purified water 68.88g 68.88% by weight

[0058] Corn oil 3g 3% by weight

[0059] Polyoxyethylene castor oil 3g 3% by weight

[0060] Polysorbate 80 0.5g 0.5% by weight.

[0061] Oil phase preparation: Mix and heat corn oil, polyoxyethylene castor oil, lecithin, and polysorbate 80, control the temperature at 70-75°C, dissolve voriconazole in propylene glycol, and add it to the oil phase.

[0062] Water phase preparation: mix and dissolve purified water, glycerin, LGP, poloxamer, and ambroxol hydrochloride, stir and heat to a temperature of 7...

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PUM

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Abstract

The invention provides an ear drop which comprises voriconazole and one or more than one of its pharmaceutical salts, ambroxol and one or more than one of its pharmaceutical salts, and pharmaceutical adjuvants. The ear drop of the invention can effectively improve patient feeling of earache and ear fullness; the ear drop is prepared by the combination of ambroxol hydrochloride and voriconazole, and thus the application of the ear drop has significantly better effect than single application of a voriconazole ear drop or ambroxol hydrochloride, and has higher patient compliance than single application of a voriconazole ear drop, has a shorter treatment course; and it is concluded that the combination of a voriconazole ear drop and ambroxol hydrochloride for the ear drop has synergistic effect on disease cause elimination and function recovery.

Description

technical field [0001] The invention relates to voriconazole ear drops and its preparation method and application. Background technique [0002] Otitis media can generally be divided into three types: one is suppurative otitis media, which is often caused by a cold and bacterial infection. The earache is obvious at the beginning, and it is distending pain. There may be fever. After the tympanic membrane is perforated and pus is released, the pain is relieved. Conventional treatment You can choose sensitive antibiotics or oral or injection or topical ear medication, such as washing with hydrogen peroxide, and then using sensitive antibiotic ear drops; the other is called non-suppurative otitis media. Stuffiness, hearing loss or tinnitus, this is caused by the pressure change in the middle ear cavity caused by inflammation of the Eustachian tube; the third is secretory otitis media (SOM). [0003] For suppurative otitis media, if the infection cannot be treated promptly and t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/506A61K31/137A61K31/4164A61K31/5383A61K9/00A61K9/107A61K9/06A61K9/10A61P27/16A61P31/10A61P31/02
Inventor 郭国领孔祥生周俊李颖钟贞
Owner LIVZON GROUP LIVZON PHARMA FACTORY
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