Tumor treatment using ultrasound cavitation

A technology of physiological changes and movements, applied in ultrasound therapy, treatment, ultrasound/sonic/infrasonic diagnosis, etc., can solve problems such as difficulty in the range of treatment areas

Inactive Publication Date: 2012-07-04
KONINK PHILIPS ELECTRONICS NV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, the extent of the treatment area is difficult to control because blood circulation has a strong local effect on the temperature field formed in the tissue

Method used

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  • Tumor treatment using ultrasound cavitation
  • Tumor treatment using ultrasound cavitation
  • Tumor treatment using ultrasound cavitation

Examples

Experimental program
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Effect test

example

[0079] Blood flow in tumor vasculature is reduced following disruption of microbubbles by ultrasound.

[0080]Estimation of tumor blood flow by real-time ultrasound contrast imaging following high-amplitude focused ultrasound treatment in a murine model.

[0081] Microbubbles were prepared from perfluorobutane gas and stabilized with a lecithin / PEG stearate shell. MC38 murine colon adenocarcinoma cells (J. Schlom, NIH) were subcutaneously administered into the hind legs of C57BL / 6 mice. When tumors reached >5-6 mm in size, anesthetized mice were placed under a focused ultrasound transducer. Perform intravenous administration of 0.05-0.1 ml of microbubbles, followed by ten 1 Hz PRF 100K cycle pulses (TIPS TM system, Philips) delivered to the tumor by 1.2MHz 5MPa acoustic waves. Insonification is performed repeatedly, ie on an essentially daily basis, in order to achieve a reduction in tumor size. Ultrasound contrast imaging during and after insonation was performed with a C...

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Abstract

Growth in body tissue is slowed, arrested or reversed. In one aspect, this is accomplished by providing bubbles (S315), and delivering, to cause temporary change in physiology that at least one of retards, arrests and reverses said growth, a series of one or more pulses (206) of energy to respective focal points (213) at the site of the growth. In another aspect, temporary change in physiology, such as transient vasospasm (216) in vasculature of a neoplasm, is induced via the mechanical, non-thermal effects of fluid cavitation caused by the pulses. The bubbles, for facilitating the cavitation, in some embodiments, are afforded by administration of a microbubble agent to the host.

Description

technical field [0001] The present invention relates to growth control of bodily tissues, and more particularly, to the application of energy to delay, inhibit or reverse growth. Background technique [0002] All forms of cancer remain the leading cause of death worldwide. A significant shortcoming of existing and promising cancer treatments has been and continues to be toxic side effects. [0003] The heating effect of continuous wave (CW) focused ultrasound is used to kill cells in the treatment of uterine fibroids. Unfortunately, the extent of the treatment area is difficult to control because blood circulation has a strong local effect on the temperature field formed in the tissue. [0004] Non-heating methods involving ultrasonic cavitation are known to cause a range of biological effects including hemolysis, microvasculature bleeding, sonoporation, transient opening of the blood-brain barrier, apoptosis and cell death. The type and severity of biological effects dep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N7/00A61B17/22
CPCA61B2017/22008A61B8/481A61N7/00A61N2007/0039A61B17/22A61B18/00
Inventor C.T.陈C.S.哈尔A.L.克利巴诺夫
Owner KONINK PHILIPS ELECTRONICS NV
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