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Orally disintegrating tablet of ambroxol hydrochloride composition and preparation method of same

A technology of ambroxol hydrochloride and orally disintegrating tablets, which is applied in the field of pharmaceutical tablets, can solve the problems of strong tongue numbness and bitter taste, and can not solve patients' medication compliance well, so as to shorten the disintegration time and shorten the disintegration time. Time-resolving and weak tongue numbness

Inactive Publication Date: 2012-07-11
CHONGQING CONQUER PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this preparation method can play a certain role in correcting the taste, the tablet needs to stay in the oral cavity for about 1 minute to be swallowed, and its numb tongue and bitter taste will also be very strong, and it cannot solve the patient's medication compliance well.

Method used

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  • Orally disintegrating tablet of ambroxol hydrochloride composition and preparation method of same
  • Orally disintegrating tablet of ambroxol hydrochloride composition and preparation method of same
  • Orally disintegrating tablet of ambroxol hydrochloride composition and preparation method of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation method 1 of embodiment 1 ambroxol hydrochloride pharmaceutical composition orally disintegrating tablet

[0014] Ambroxol hydrochloride, menthol, sodium chloride, polacrilin potassium, micronized silica gel, xylitol, sucralose, magnesium stearate as 20:8:4:5:3:40:5:2 Take by weight 120g, make 1000 ambroxol hydrochloride pharmaceutical composition orally disintegrating tablets. The specific technical parameters are as follows:

[0015] 1) Particle size requirements of raw and auxiliary materials: Ambroxol hydrochloride, sodium chloride, micronized silica gel, menthol, sucralose, and magnesium stearate with a particle size of less than 180 microns; polacrilin potassium and xylitol with a particle size of less than 250 microns.

[0016] 2) Take the prescribed amount of ambroxol hydrochloride, sodium chloride, micro-powdered silica gel, menthol, sucralose, magnesium stearate, polacrilin potassium, and xylitol and add them to the three-dimensional motion mix...

Embodiment 2

[0018] The preparation method 2 of embodiment 2 ambroxol hydrochloride pharmaceutical composition orally disintegrating tablet

[0019] Ambroxol hydrochloride, menthol, sodium chloride, polacrilin potassium, micronized silica gel, xylitol, sucralose, magnesium stearate as 15: 15: 15: 7: 5: 60: 7: 3 Take by weight 120g, make 1000 ambroxol hydrochloride pharmaceutical composition orally disintegrating tablets.

Embodiment 3

[0020] The preparation method 3 of embodiment 3 ambroxol hydrochloride pharmaceutical composition orally disintegrating tablet

[0021] Ambroxol hydrochloride, menthol, sodium chloride, polacrilin potassium, micronized silica gel, xylitol, sucralose, and magnesium stearate are 45:4:1:2:1:30:2:1 Take by weight 120g, make 1000 ambroxol hydrochloride pharmaceutical composition orally disintegrating tablets.

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Abstract

The invention provides an orally disintegrating tablet of ambroxol hydrochloride composition which comprises ambroxol hydrochloride, menthol, sodium chloride, polacrilin potassium, colloidal silicon dioxide, xylitol, trichloromethyl and Magnesium stearate, wherein the weight ratio of ambroxol hydrochloride and menthol as major active components is (15-45): (4-15). The orally disintegrating tablet of ambroxol hydrochloride composition has expectorant and antitussive activities, can be used for treatment of pharyngolaryngitis, has no problems occurring during throat disease treatment with the existing ambroxol hydrochloride medicaments in combination with other medicaments, and has excellent efficacy. Besides, the disintegration time of the orally disintegrating tablet of ambroxol hydrochloride composition is greatly reduced, and the orally disintegrating tablet is well accepted by patients.

Description

technical field [0001] The present invention relates to a kind of medicine tablet, relate to a kind of orally disintegrating tablet of ambroxol hydrochloride pharmaceutical composition and preparation method thereof more specifically. technical background [0002] Ambroxol hydrochloride is a mucolytic agent, and its chemical name is trans 4-[(2-amino-3,5-dibromo-phenyl)methyl-amino]cyclohexanol hydrochloride. It tastes bitter and very tongue-numbing. It has the characteristics of promoting mucus elimination and dissolving secretions. It can promote the elimination of viscous secretions in the respiratory tract and reduce the retention of mucus, thus significantly promoting expectoration and improving respiratory conditions. When this product is used for treatment, the patient's mucus secretion can return to normal conditions. Cough and sputum volume are usually significantly reduced, so that the surface active substances on the respiratory mucosa can exert their normal pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61K9/20A61K47/32A61P11/00A61K31/137
Inventor 梅勇罗磊何远东马贵勇姜艳红
Owner CHONGQING CONQUER PHARML
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