Traditional Chinese medicine composition for treating hyperlipemia fatty liver, as well as preparation method, quality detection method and application thereof

A technology of hyperlipidemia and composition, applied in the field of traditional Chinese medicine, can solve problems such as skin flushing, drug absorption effects, discomfort, etc.

Active Publication Date: 2012-07-11
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

② Nicotinic acid and its derivatives can inhibit the synthesis of VLDL and LDL, but affect the excretion of TG in liver cells. From this point of view, it is not suitable for the treatment of fatty liver; the main adverse reactions are skin flushing, gastrointestinal discomfort, At the same time, it can reduce glucose tolerance, increase blood uric acid, and affect liver function, so it is contraindicated for people with diabetes, gout, and liver insufficiency
Hawthorn, Alisma, Cassia, and Red Yeast, combined with Ganlixin Capsules to treat hyperlipidemia fatty liver, the existing technical problems are: ordinary capsules have the disadvantage of slow disintegration speed, which has certain effects on drug absorption. Influenced by large volume, or often need to use multiple capsules at a time, it needs to be taken with water, which is inconvenient to take, especially for the elderly, young and patients with swallowing dysfunction.

Method used

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  • Traditional Chinese medicine composition for treating hyperlipemia fatty liver, as well as preparation method, quality detection method and application thereof
  • Traditional Chinese medicine composition for treating hyperlipemia fatty liver, as well as preparation method, quality detection method and application thereof
  • Traditional Chinese medicine composition for treating hyperlipemia fatty liver, as well as preparation method, quality detection method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1: Granules

[0071] 1. The composition of the traditional Chinese medicine composition: Gentiana 233g, Salvia miltiorrhiza 334g, Radix Paeoniae Rubra 233g, Rhizoma Chuanxiong 233g, Cassia officinalis 334g and Alisma 200g.

[0072] 2. Preparation method:

[0073] 1) Add water to decoct the six flavors of traditional Chinese medicine raw materials twice, each time for 1.5 hours (the amount of water each time is 8 times that of all the traditional Chinese medicine raw materials), combine the decoction, filter, and concentrate the filtrate under reduced pressure to obtain the relative density Concentrate of 1.10-1.20 (measured at 50°C);

[0074] 2) Let the concentrated solution obtained in step 1) cool down, add ethanol (concentration: 95%) so that the alcohol content is 55% of the total Chinese medicine raw materials, stir well, leave it for 24 hours, filter, reclaim ethanol and concentrate the filtrate To a thick paste with a relative density of 1.30-1.35 (m...

Embodiment 2

[0076] Embodiment 2: Granules

[0077] 1. Composition of traditional Chinese medicine composition: gentian 233g, salvia miltiorrhiza 334g, red peony 233g, chuanxiong 233g, cassia 334g, Alisma 200g, raw barley 233g, tangerine peel 200g, toosendan 167g, Polygonum multiflorum 233g, hawthorn 200g and licorice 83.5g g.

[0078] 2. Preparation method:

[0079] 1) The twelve traditional Chinese medicine raw materials are decocted twice with water, each time for 1 hour (the amount of water each time is 7 times that of all the traditional Chinese medicine raw materials), the decoctions are combined, filtered, and the filtrate is concentrated under reduced pressure to obtain Concentrate with a relative density of 1.10-1.20 (measured at 50°C);

[0080] 2) Let the concentrated solution obtained in step 1) cool down, add ethanol (concentration: 95%) to make the alcohol content 60% of the total Chinese medicine raw materials, stir well, leave it for 24 hours, filter, reclaim ethanol and c...

Embodiment 3

[0082] Embodiment 3: common tablet

[0083] 1. Composition of traditional Chinese medicine composition: gentian 300g, salvia miltiorrhiza 300g, red peony 200g, chuanxiong 300g, cassia 300g, Alisma 190g, raw barley 200g, tangerine peel 220g, toosendan 150g, Polygonum multiflorum 200g, hawthorn 220g and licorice 95g .

[0084] 2. Preparation method:

[0085] 1) Add water to decoct the twelve traditional Chinese medicine raw materials for 3 times, each time for 1 hour (the amount of water each time is 8 times that of all the traditional Chinese medicine raw materials), combine the decoction, filter, and concentrate the filtrate under reduced pressure to obtain Concentrate with a relative density of 1.10-1.15 (measured at 50°C);

[0086] 2) Let the concentrated solution obtained in step 1) cool down, add ethanol (concentration: 95%) to make the alcohol content 60% of the total Chinese medicine raw materials, stir well, leave it for 24 hours, filter, reclaim ethanol and concentra...

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Abstract

The invention relates to a traditional Chinese medicine composition for treating hyperlipemia fatty liver, as well as a preparation method, a quality detection method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition contains the following traditional Chinese medicine raw materials: 150-400 parts of rough gentian, 200-500 parts of radix salviae miltiorrhizae, 150-400 parts of red paeonia or/and 150-400 parts of hemlock parsley, 200-500 parts of semen cassiae torae and 150-280 parts of alisma rhizome. The traditional Chinese medicine composition provided by the invention can be used for liver and gall moist heat and syndrome of static blood blocking collaterals, as well as fatty liver and hyperlipemia patients with the following symptoms: two ribs swell and pain, mouth is dry and bitter, the appetite is poor, the limbs and trunk are sleepy, the abdomen feels full, stool is viscous or constipation happens, the tongue proper is dark and has petechia, and the tongue proper is yellow, thick or oily.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating hyperlipidemia fatty liver, its preparation method, its quality detection method and its application. Background technique [0002] Fatty liver is a clinicopathological syndrome characterized by hepatic parenchymal cell degeneration and fat accumulation. According to epidemiological surveys, the pathogenic factors closely related to fatty liver include hyperlipidemia, alcoholism, obesity, diabetes and so on. In recent years, with the changes in people's diet structure and lifestyle, the incidence of hyperlipidemia has increased year by year, and it has become the most important factor inducing fatty liver. In addition, about 25% of fatty liver patients can develop liver fibrosis, and 1.5%-8% can progress to liver cirrhosis. Therefore, early recognition and prevention of hyperlipidemia fatty liver is of great sig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K36/8994A61K36/9066A61P3/06A61P1/16
Inventor 付立家付建家马云赵敏姿
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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