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Mailuoning composition with new prescription

A kind of composition, technology of mailuoning, applied in the field of new formula mailuoning composition

Active Publication Date: 2012-07-11
JINLING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there is no bibliographical report on the relationship between the dosage and drug efficacy of honeysuckle and mountain silver flower in Mailuoning formula according to the 2005 edition pharmacopoeia

Method used

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  • Mailuoning composition with new prescription
  • Mailuoning composition with new prescription
  • Mailuoning composition with new prescription

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: The scavenging effect of different ratios of honeysuckle and mountain silver flower in Mailuoning injection on hydroxyl free radicals

[0028] 1. Purpose of the experiment:

[0029] Mailuoning injection (prepared by the method of Example 9, but the weight ratio of honeysuckle and mountain silver flower in the formula is different, respectively: 100: 0, 80: 20, 70: 30, 64: 36, 60: 40, 50 : 50, 0: 100. The same below) used two medicinal materials, honeysuckle and mountain silver flower, and observed the scavenging effect of these two medicinal materials on hydroxyl free radicals in different proportions.

[0030] 2. Experimental method

[0031] In the test tube, add 0.5ml of 9mmol / L salicylic acid-ethanol solution, 0.5ml of different concentrations of samples to be tested, 9mmol / L Fe 2+ Solution (now prepared) 0.5ml, 3.5mL distilled water, finally add 8.8mmol / LH 2 o 2 Start the Fenton reaction with 5ml, react at 37°C for half an hour, shake well and measur...

Embodiment 2

[0042] Example 2: The protective effect of different ratios of honeysuckle and mountain silver flower in Mailuoning on the oxidative damage of endothelial cells induced by hydrogen peroxide

[0043] 1 Test purpose

[0044] To observe the protective effect of different proportions of honeysuckle and mountain silver flower in Mailuoning injection on the oxidative damage of endothelial cells induced by hydrogen peroxide.

[0045] 2 Experimental methods

[0046] HUVECs were resuscitated according to conventional methods and inoculated in 40ml culture flasks, the culture medium was RPMI1640 culture medium with 10% fetal bovine serum, 37°C, 95% O 2 , 5%CO 2 Cultivate under certain conditions. After the cells grow to the bottom of the bottle, pour off the culture medium and wash it twice with PBS gently, add 0.25% trypsin to digest at 37°C for 2-3min, stop the digestion with fetal calf medium, pipette several times , to completely disperse the cells. Transfer the cell suspension ...

Embodiment 3

[0058] Example 3: Protective effect of different ratios of honeysuckle and mountain silver flower in Mailuoning on MCAO rats

[0059] 1 Experiment purpose:

[0060] To observe the protective effect of different proportions of honeysuckle and mountain silver flower in Mailuoning injection on MCAO rats.

[0061] 2 Experimental methods

[0062] SD rats were randomly divided into model group, sham operation group, 100:0 group, 80:20 group, 70:30 group, 64:36 group, 60:40 group, 50:50 group, 0:100 group, A total of 9 groups, the dose of each group was 17.2g / kg, administered through tail vein injection. The model group was given an equal volume of normal saline. Rats were anesthetized with 10% chloral hydrate (350mg / kg) intraperitoneally, placed supine on the operating table after anesthesia, cut from the frontal line of the neck, and separated the right common carotid artery, external carotid artery, and internal carotid artery. The distal end of the external carotid artery was...

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Abstract

The invention belongs to the field of Chinese medicine pharmacy, and discloses a mailuoning composition. The composition is prepared from the following raw material drugs in parts by weight: 1 to 4 parts of honeysuckle and lonicera confusa, 1 to 4 parts of dendrobe, 1 to 4 parts of twotooth achyranthes root, and 1 to 4 parts of figwort root, wherein on the basis of 100 percent of the weight sum of the honeysuckle and the lonicera confusa, the ratio of the honeysuckle to the lonicera confusa is between 20 percent and 50 percent:50 percent. According to the specification of drugs in the Chinese Pharmacopoeia 2005 edition, the honeysuckle and the lonicera confusa are itemized, and the proportion between the two drugs are studied by adopting a plurality of pharmacological experiments, and an optimized proportion between the two drugs is selected.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy and relates to a new formula of Mailuoning composition. Background technique [0002] Mailuoningyuan is made of four medicinal materials: honeysuckle, Dendrobium, Achyranthes bidentata, and Scrophulariae, which has the functions of clearing heat, nourishing yin, promoting blood circulation and removing blood stasis. For thromboangiitis obliterans, arteriosclerotic obliterans, cerebral thrombosis and sequelae, venous thrombosis and other diseases. Pharmacological studies have shown that Mailuoning has the functions of protecting heart and cerebrovascular tissue, anti-thrombosis, improving microcirculation and blood rheology. The preparations of Mailuoning generally include granules, injections, oral liquids, etc. [0003] The 2000 edition of the Pharmacopoeia stipulates that honeysuckle is the dry flower bud or flower with the first bloom of honeysuckle, honeysuckle red gland,...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P7/02A61P9/00A61P9/10
Inventor 陈振飞徐向阳蔡莹孙晔张蕙方泰惠谢俊周红燕张庆晓夏云
Owner JINLING PHARMA
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