Optical detection device and method for concentration of components in turbid medium based on limited range wavelength method

Abstract

The invention relates to an optical detection device and a method for concentration of components in a turbid medium based on a limited range wavelength method. The device is characterized in that a light source is connected with the turbid medium through a coupled optical fiber detecting head, the turbid medium is connected with a spectral filtering system through the coupled optical fiber detecting head, and the spectral filtering system is sequentially connected with a photoelectric detection unit, a single chip microcomputer and a display screen. The spectral filtering system is composed of a transflective prism and a light filter and is used for splitting into 2, 4, 8, ... and 2n beams of light. In the method, for the determination of limited number of wavelengths, the absorption information of bilirubin at a benchmark wavelength is adopted to remove skin background and stray light interference, and the wavelengths relevant to hemoglobin and melanin absorption with largest influence on the concentration detection of bilirubin are adopted to remove the influence of these influencing factors; and an optimal optical path length principle is adopted to calculate the optimal optical path length during the optical detection of bilirubin and is used for designing an optical detecting head. According to the device and the method, the concentration of a certain component in the turbid medium can be measured more accurately and conveniently, and the non-invasive, dynamic and continuous detection for the concentration of components in the turbid medium can be realized.

Description

technical field [0001] The invention relates to a method for detecting the component concentration of a chaotic medium. In particular, it relates to an optical detection device and method for the concentration of components in a chaotic medium based on a finite wavelength method. Background technique [0002] The application of optical methods to detect components in the human body (such as bilirubin) is mainly based on the light diffused and reflected from the inside of the human skin with the information of the skin tissue components. Human skin tissue is a chaotic medium with high scattering and absorption properties. The optical detection of the concentration of components in such a chaotic medium requires targeted consideration. The determination of the detection method and the construction of the detection system are mainly based on the substances to be detected and related interferences. The optical properties of the factor. [0003] Taking bilirubin as an example, ...

AI Technical Summary

Problems solved by technology

There are two defects in the diazo method: one is that the diazo reagent is unstable, it must be temporarily generated by sodium nitrite and aminobenzenesulfonic acid, and it can only be stored for 2 days at most after generation; the other is that the diazo reagent and conjugated bilirubin Poor specificity of response to bile (Bc) and sigma bilirubin (Bσ)

Due to the large individual differences in the human body and many influencing factors, the accuracy of the final test result is poor, and it cannot be used for clinical diagnosis. It can only be used for the screening of neonatal bilirubin concentration detection.

Bilicheck adopts a multi-wavelength (137 wavelengths) detection method (McKenzie J2010), which has improved the above problems, but multi-wavelength will inevitably increase the cost of the instrument and increase the complexity of the data processing algorithm, which will affect the popularization and application of the instrument

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