18 results about "Bilirubin concentration" patented technology

The invention discloses a continuous monitoring method for neonatal jaundice and a related device. The method comprises the steps that a sensor module arranged on a patch or a bracelet is used for percutaneously measuring the bilirubin level of a neonate; the measurement data of the photoelectric sensor is corrected according to the data of the temperature sensor, the bilirubin level of the newborn is calculated through a preset bilirubin model based on the corrected data of the photoelectric sensor, and the preset bilirubin model comprises a light absorption model and a dynamic correction model; establishing a relation model of light absorption and bilirubin concentration by the light absorption model; the dynamic correction model adjusts parameters of the light absorption model; and transmitting the bilirubin level to a remote server, and when the bilirubin level exceeds a preset alarm threshold, generating an alarm signal and pushing the alarm signal to a medical staff client and / or a parent client. According to the invention, personalized continuous monitoring of neonatal jaundice is realized through a dynamic correction model, an intelligent alarm threshold, closed-loop control and auxiliary treatment means.

The application provides a bilirubin adsorber and a method for detecting the concentration of bilirubin. The bilirubin adsorber comprises an adsorber body and a bilirubin detector. The adsorber body is provided with a limiting groove, and the bilirubin detector is arranged in the limiting groove. The area of the adsorber body corresponding to the limiting groove is provided with a transparent detection window, so that the bilirubin detector can detect the concentration of bilirubin in the plasma inside the adsorber body through the detection window. The application can accurately detect the concentration of bilirubin, and facilitate medical staff to accurately determine the saturation degree of the bilirubin adsorber.

The invention belongs to the technical field of jaundice determination, and discloses a portable household neonatal jaundice determination device which comprises a holding handle part, an outer shell is fixedly installed at one end of the holding handle part, a detection groove is formed in the bottom of the outer shell, and a control circuit unit, a light source module and a photodiode are arranged in the detection groove. According to the neonatal detection device, blue light LEDs, green light LEDs, photodiodes and the like are arranged, when the neonatal detection device is used, parents move the outer shell to the forehead of a neonatal and then press the outer shell downwards to make contact with the skin, the blue light LEDs and the green light LEDs which are alternately installed are used for emitting light of different wavelengths, and the detection effect is good. According to the bilirubin concentration measuring device, the photoelectric diode is used for receiving, then the control circuit unit and the microcontroller are used for calculation, interference of factors such as hemoglobin and skin thickness can be eliminated by comparing the ratio of the intensity of reflected light with two wavelengths, and the bilirubin concentration can be accurately measured.

The invention relates to the technical field of medical instruments, in particular to a control method and system of a jaundice treatment device. The method comprises the following steps: acquiring evaluation data of a user, wherein the evaluation data comprises spectral reflectivity; inputting the evaluation data into a preset prediction model to obtain a bilirubin concentration risk score and a bilirubin concentration prediction value at a next prediction moment; in response to the bilirubin concentration risk score being greater than a risk threshold, determining a candidate interval corresponding to a phototherapy parameter based on the bilirubin concentration risk score, the phototherapy parameter including a light source wavelength; inputting the predicted value of the bilirubin concentration into an MPC optimizer, so that the MPC optimizer selects an optimal phototherapy parameter from the candidate interval; and outputting the optimal phototherapy parameter, so that the jaundice treatment device outputs a corresponding treatment light source. According to the method, the condition of excessive treatment can be avoided.

This utility model relates to the field of bilirubin concentration detection technology, and mainly to an extraction device for bilirubin concentration detection. It includes an aspirator tube for serum aspiration, a storage frame, and an operating tube. Multiple aspirator tubes are inserted into the storage frame. The operating tube has a connector, and the connector and the storage frame have a docking part. The storage frame has a pushing part for moving multiple aspirator tubes into the operating tube, and a pushing component is located inside the operating tube. This utility model optimizes the traditional serum collection method for bilirubin concentration detection. By using a designed negative pressure adsorption component in conjunction with the aspirator tube, it achieves the absorption and storage of the upper serum layer. Compared with the traditional method of immediate transfer after aspirating with a pipette, personnel can extract all the serum in batches at once. During operation, it effectively avoids forgetting to replace the pipette or serum contamination caused by contact between the pipette and the outside environment.

The invention relates to the technical field of neonatal jaundice monitoring, in particular to a neonatal jaundice follow-up monitoring system. The system obtains bilirubin concentration data of a current newborn; according to the similar condition of the daily bilirubin concentration data between the historical newborn and the current newborn, obtaining a matching day of the current day of the historical newborn and the current day of the current newborn; the newborns with pathological jaundice in the historical newborns are used as a first category, the newborns with non-pathological jaundice are used as a second category, and bilirubin concentration data in the current day of the current newborn and the matching day of the historical newborns in each category are determined according to the similar condition of the bilirubin concentration data in the current day of the current newborn; and obtaining the category of the current day of the current newborn so as to determine the jaundice severity of the current day of the current newborn. By comparing the bilirubin concentration data of the current newborn with the bilirubin concentration data of the historical newborn, the jaundice severity of the current newborn can be accurately analyzed in real time, and the jaundice problem of the current newborn can be solved in time.

A jaundice diagnosis and treatment system includes a control circuit, a bilirubin measurement assembly, a risk evaluation circuit and a display assembly, wherein the bilirubin measurement assembly is communicatively connected to the control circuit, and is used for measuring a bilirubin concentration of a newborn baby and transmitting the measured bilirubin concentration to the control circuit, so that the control circuit generates measurement data according to the measured bilirubin concentration; the risk evaluation circuit is communicatively connected to the control circuit, and is used for acquiring the measurement data from the control circuit and evaluating a pathologic jaundice risk level according to the measurement data; and the display assembly is connected to the control circuit, and is used for displaying the measurement data and / or the pathologic jaundice risk level under the control of the control circuit.

The invention discloses a jaundice detection device for child treatment, and relates to the technical field of jaundice treatment and detection. The system comprises a treatment bed, the treatment bed is provided with an image acquisition unit, a data transmission unit, a phototherapy unit, an intelligent control unit and an output unit, and the intelligent control unit comprises a data preprocessing module, a feature extraction module, a jaundice diagnosis module and a treatment suggestion module. The mode of combining computer vision, intelligent control and the phototherapy technology is adopted, intelligent diagnosis and treatment of neonatal jaundice are achieved, and the system has the advantages of being easy to operate, high in precision, safe and reliable; the blue light which reduces the oxidative pressure of the newborns can reduce the concentration of bilirubin in blood, the oxidative pressure of the newborns can be reduced, the concentration of bilirubin in blood can be reduced, and the jaundice treatment effect on the newborns (extremely low birth weight) with the birth weight less than 1500 g is especially achieved.

1. The name of this design product: Transcutaneous Jaundice Device. 2. Purpose of this product design: used to measure the bilirubin concentration in newborns. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

A non-invasive device (10) includes contact tip member (12) configured to contact skin surface of body of person, optical beam concentrator (18) disposed at least partially within contact tip member (12), optical detection unit (14) coupled to contact tip member (12). The optical detection unit (14) includes optical housing (22), light source (20) disposed within optical housing (22) and configured to emit white light, plurality of optical members disposed within optical housing (22). It further includes optical sensor (32) having optical filter (34) and photodiode layer (36) disposed on optical filter (34), disposed within optical housing (22). The optical detection unit (14) further includes casing (16) coupled to optical detection unit. The device (10) further includes processing unit (48) configured to determine a value indicative of concentration of bilirubin based on output from optical sensor (32), using predetermined equation obtained from statistical based regression analysis technique.

The invention relates to the technical field of bilirubin concentration detection, and mainly relates to a bilirubin concentration detection device, which comprises suction tubes for sucking serum, a storage frame and an operation tube, the storage frame is used for storing a plurality of suction tubes, the operation tube is provided with a butt joint port, and the butt joint end of the butt joint port and the storage frame is provided with a butt joint part. According to the bilirubin concentration detection device, a traditional serum collection mode during bilirubin concentration detection is optimized, the designed negative pressure adsorption assembly and the suction pipes are matched with each other, absorption and storage of upper-layer serum are achieved, the concentration of the bilirubin is detected, the concentration of the bilirubin is detected, the concentration of the bilirubin is detected, the concentration of the bilirubin is detected, and the concentration of the bilirubin is detected. Compared with the traditional mode that the serum needs to be transferred immediately after being sucked by a suction tube, the serum extraction device has the advantages that a worker can extract all serum in batches at one time, and serum pollution caused by the fact that the suction tube is forgotten to be replaced and the suction tube is in contact with the outside can be effectively avoided in the operation process.

The invention discloses an artificial hepatobilirubin dynamic monitoring system and method based on multi-wavelength spectrum analysis, relates to the technical field of medical instruments, and aims to eliminate common interference of a detected sample by utilizing a detection light source combined by multiple wavelengths, namely by combining a characteristic light source and a reference light source. According to a multi-wavelength differential measurement technology, an optical compensation mechanism and an absorbance difference value, the bilirubin concentration of a measured sample is continuously and dynamically monitored, the bilirubin purification effect is evaluated in real time, the reliability and accuracy of real-time measurement of the bilirubin concentration in the measured sample are improved, and the accuracy of real-time measurement of the bilirubin concentration in the measured sample is improved. The dynamic bilirubin measuring unit in the monitoring system can be placed at any position of the artificial liver to meet the requirement for continuous monitoring of the bilirubin concentration in artificial liver treatment, so that the system can quantify the bilirubin concentration in real time, is used for a human body blood purification system, realizes real-time measurement of the human body bilirubin concentration in the treatment period, and has good application prospects. Therefore, a doctor can evaluate the treatment effect timely according to the bilirubin purification effect.

The invention relates to the field of in-vitro diagnosis, in particular to a blood cell analyzer and method for detecting bilirubin in a sample and a computer readable storage medium. Scattered light information and fluorescence information of leukocytes of to-be-detected sample liquid are obtained through a leukocyte measuring device; acquiring particle information of at least one target particle swarm from the scattered light information and the fluorescence information by using a data processing device, and inputting the acquired particle information of the at least one target particle swarm into a preset calculation model as an input parameter; the output of the calculation model is obtained to serve as bilirubin mark parameter information of the blood sample, information about whether bilirubin is abnormal or not and bilirubin concentration information, bilirubin information and leukocyte detection results of the blood sample are synchronously obtained in the blood routine detection process, extra detection reagents or methods are not needed, and the detection efficiency is improved. Clinical detection cost is not increased, and detection is convenient and accurate.

The present application relates to the technical field of bilirubin concentration detection, and mainly relates to a bilirubin concentration detection device, which comprises a suction tube for serum suction, a storage frame and an operation tube, the storage frame is used for storing a plurality of suction tubes, a docking port is arranged on the operation tube, the docking port and the storage frame are provided with a docking part at the docking end, a pushing part for moving the plurality of suction tubes into the operation tube is arranged in the storage frame, and a pushing assembly is arranged in the operation tube, the present application optimizes the traditional serum collection method during bilirubin concentration detection, the designed negative pressure adsorption assembly is matched with the suction tube, the absorption and storage of the upper serum are realized, compared with the traditional method of immediately transporting after suction by a suction tube, personnel can extract all the serum at one time, and in the operation process, the serum pollution caused by forgetting to replace the suction tube and the contact between the suction tube and the outside can be effectively avoided.

The invention relates to a preparation method of a bilirubin detection kit by using a chemiluminescence immunoassay technology. Bilirubin is an important basis for clinically judging jaundice and is also an important index of liver functions. As bilirubin is small in molecular weight and poor in immunogenicity, when a corresponding antibody is prepared, a proper derivative site needs to be selected firstly, and a derived hapten is coupled with a specific macromolecular carrier to prepare a complete antigen. According to the invention, the antibody with good specificity and strong affinity is successfully prepared by designing and transforming the hapten. The invention mainly relates to design and synthesis of a bilirubin hapten, preparation of a bilirubin complete antigen and an anti-bilirubin antibody, a method for determining the concentration of bilirubin, and composition and components of a reagent. The design and synthesis of the hapten mainly comprise design and chemical synthesis of bilirubin derivatives. The bilirubin derivative disclosed by the invention has a structure as shown in a formula (I) which is described in the specification.

The application discloses a bilirubin concentration detection device, comprising a reagent arm module and a sample arm module, which both comprise a sample inlet needle, an execution arm and a connecting head, the sample inlet needle is kept synchronous activity with the execution arm through the connecting head, and the device further comprises a first driving mechanism, a second driving mechanism, a transmission mechanism and a motor; the first driving mechanism comprises a screw nut, the transmission mechanism couples the motor to the first driving mechanism and drives the screw nut to rotate, so that the execution arm moves along the vertical direction; the second driving mechanism comprises a spline nut, the transmission mechanism couples the motor to the first driving mechanism and the second driving mechanism and simultaneously drives the screw nut and the spline nut to rotate, so that the execution arm swings along the horizontal direction. The bilirubin concentration detection device provided by the application simplifies the circuit relationship of the equipment, avoids the complicated work of circuit maintenance, and is far superior to the time of circuit troubleshooting in the troubleshooting efficiency of mechanical failure, thereby facilitating the later repair work of the equipment.

The present application provides a kind of newborn noninvasive bilirubin real-time monitoring system based on near infrared spectroscopy, comprising: monitoring bracelet, mobile terminal and / or hospital monitoring system, bracelet integrates multi-wavelength near infrared sensor and AI algorithm, noninvasive, continuously monitor the concentration change of bilirubin through wrist skin, and real-time wireless transmission to terminal, realize jaundice dynamic management.Using near infrared spectroscopy technology, without blood sampling, noninvasive monitoring, 24 hours continuous tracking of bilirubin concentration dynamic change, avoid the pain and infection risk of invasive operation, can be used as a substitute or supplementary means for serum detection.According to the day age of newborn, set personalized threshold according to weight, combined with concentration change rate dynamic early warning, early signs of pathological jaundice are found, early warning response time ≤1 minute, the incidence of kernicterus is reduced by 25%, effectively guarantee the life and health of newborn.

A jaundice analysis system includes a database and a processing device for accessing the database. The processing device includes: a data processing module for generating a training data according to an image data, correlating the training data with a category data, and storing the training data in the database; and a deep learning module for training a target convolutional neural network module with the training data correlating with the category data to obtain a trained convolutional neural network module. The image data includes a first sclera image. The trained convolutional neural network module of the processing device generates a testing data according to an input image data. The input image data includes a second sclera image of a target subject. The testing data indicates the target subject's bilirubin concentration range.