Silk fibroin micro-needle system, silk fibroin nanometer particle and preparation method thereof

Abstract

The invention discloses a silk fibroin micro-needle system, a silk fibroin nanometer particle and a preparation method thereof. The dissolvable silk fibroin micro-needle system comprises a base plate and a micro-needle, and is characterized in that a body of the micro-needle consists of silk fibroin protein condensate, the silk fibroin protein condensate penetrates into the skin of a user, and micro-pipes are remained on the skin of the user after the silk fibroin protein condensate is dissolved. The silk fibroin nanometer particle is characterized by comprising silk fibroin protein molecules and cosmetic molecules or medicine molecules, the silk fibroin protein molecules wrap the cosmetic molecules or the medicine molecules to form a particle structure, antibody or aptamer molecules can be attached onto the surface of the silk fibroin nanometer particle, and the degradation speed of the silk fibroin nanometer particle in the body of the user can be controlled by means of adjusting crystalline degree of silk fibroin protein. A method for delivering medicine or cosmetic is characterized by comprising steps of penetrating the silk fibroin protein condensate of the body of the micro-needle into the skin of the user, dissolving the silk fibroin protein condensate, and releasing nanometer silk fibroin particles wrapped with the medicine or the cosmetic so that the medicine molecules or the cosmetic molecules are delivered; or delivering the medicine molecules or the cosmetic molecules via the micro-pipes remained on the skin of the user after the silk fibroin protein condensate is dissolved in a permeation manner, and the like.

Description

technical field [0001] The present invention relates to a medical microneedle system, especially a dissolvable microneedle system composed of silk fibroin cured product, silk fibroin particles, a patch based on the microneedle system, their preparation method and control of microneedle delivery Quantitative method. Background technique [0002] How to accurately and effectively deliver the drug to the site where it needs to be treated, so as to maximize the efficacy of the drug is a problem faced by the medical field. Microneedle array, as a precise and small tool, can be widely used in biomedical measurement, drug or cosmetic delivery, microfluidic sampling and other fields. It has the characteristics of small size, high strength, and biocompatibility of materials. Control the depth of the puncture, thereby reducing the damage of the puncture site, achieving the goal of painlessness, and providing patients with efficient and safe medical methods, which is more in line with...

AI Technical Summary

Problems solved by technology

However, the mechanical strength of general polymer microneedles is poor, and the preparation temperature is too high to maintain the activity of drugs or cosmetics, and the harmfulness of non-biological material polymers to the human body after degradation in the body remains to be studied

The most important problem is that the existing microneedle delivery technology can only deliver drugs on the surface of the skin, and the amount of drug delivery is small. Some drug molecules penetrate into the body and are degraded by the bod

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