3-nitro-8-ethyoxyl-2H-chromene compound and preparation method and application thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANDONG UNIV
- Publication Date
- 2012-07-18
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of medicine, and specifically relates to 3-nitro-8-ethoxy-2H-benzopyran compounds, their preparation method and application. Background technique
[0002] Cancer is a common and frequently-occurring disease that seriously threatens human health. Statistics in the past ten years show that the mortality rate of human beings due to cancer is second only to cardiovascular and cerebrovascular diseases, and the incidence of cancer is also increasing year by year. Drugs for the treatment of clinical tumors are currently divided into traditional cytotoxic drugs and new molecular targeted drugs. The former mainly acts on DNA, RNA, tubulin and other common components that are critical to cell life and death, resulting in low selectivity and high toxicity; while the latter mainly acts on the regulation of cell proliferation and growth that is very different in normal cells and tumor cells. Key molecules and their sig...