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Method for preparing composite phospholipid sterol lipid

A compound phospholipid and lipid technology, which is applied in liposome delivery, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as waste of resources, inability to control product quality, and limited technical parameters, and achieve excellent stability Effect

Active Publication Date: 2013-10-16
河北格川科技发展集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Since the technical method does not limit the relevant technical parameters, the product quality cannot be controlled during the production process.
Create a large number of waste products, causing a great waste of resources

Method used

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  • Method for preparing composite phospholipid sterol lipid
  • Method for preparing composite phospholipid sterol lipid
  • Method for preparing composite phospholipid sterol lipid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Preparation of complex phospholipid sterol lipid

[0057] 1. Prescription

[0058]

[0059] 2. Craft:

[0060] 1. Weigh 82.4g of refined soybean phospholipids, 17.5g of cholesterol and 0.1001g of vitamin E in the prescription amount, dissolve them with absolute ethanol, and mix them evenly.

[0061] 2. Put the lipid solution on a rotary evaporator and remove the absolute ethanol under reduced pressure to obtain a lipid mass.

[0062] Total weight: 99.1g (yield 99.1%)

[0063] The mass ratio of cholesterol to soybean lecithin is 0.204

Embodiment 2

[0065] prescription:

[0066]

[0067] operating:

[0068] 1. Weigh 18.2g of soybean phospholipids, 3.9g of cholesterol and 0.0112g of vitamin E in a prescription amount, put them in a beaker, dissolve them with absolute ethanol, mix well, and filter.

[0069] 2. Put the lipid solution on a rotary evaporator and remove the absolute ethanol under reduced pressure to form a film to obtain a lipid mass.

[0070] Total weight: 21.3g (yield 96.8%)

[0071] The mass ratio of cholesterol to soybean lecithin is 0.211

Embodiment 3

[0073] prescription:

[0074]

[0075] operating:

[0076] 1. Weigh 165.1g of soy phospholipids, 35.2g of cholesterol and 0.2019g of vitamin E in the prescription amount, dissolve them with absolute ethanol, mix well, and filter.

[0077] 2. Put the lipid solution on a rotary evaporator and remove the absolute ethanol under reduced pressure to form a film to obtain a lipid mass.

[0078] Total weight: 197.4g (yield 98.7%)

[0079] The mass ratio of cholesterol to soybean lecithin is 0.213

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PUM

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Abstract

The invention relates to a method for preparing composite phospholipid sterol lipid. The preparation method comprises the following steps of: 1, weighing soybean phospholipid, cholesterol and vitamin E, dissolving by using absolute ethyl alcohol, uniformly mixing and filtering; and 2, putting the lipid solution on a rotary evaporator, decompressing, removing the absolute ethyl alcohol, and forming a film to obtain lipid lumps.

Description

Technical field: [0001] The invention relates to a method for preparing liposomes, in particular to a method for preparing composite phospholipid sterol lipids. Background technique: [0002] Liposome is a kind of artificial membrane. In the water, the hydrophilic head of the phospholipid molecule is inserted into the water, and the hydrophobic tail of the liposome extends to the air. After agitation, a spherical liposome with a double-layer lipid molecule with a diameter ranging from 25 to 1000 nm is formed. Liposomes can be used for genetically modified or prepared drugs. The liposomes can fuse with cell membranes to deliver drugs into cells. Biological definition: When amphiphilic molecules such as phospholipids and sphingolipids are dispersed in the water phase, the molecules are hydrophobic The tails tend to gather together to avoid the water phase, while the hydrophilic head is exposed to the water phase, forming closed vesicles with a bilayer structure called liposomes. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K31/405A61P27/02
Inventor 史雪燕
Owner 河北格川科技发展集团有限公司