Dispensing nozzle for automatic analyzer, and automatic analyzer including the same
By using a combined technology of PEG derivatives and a silicon oxide layer on the surface of the dispensing nozzle of the automatic analysis device, the adsorption of biological macromolecules such as proteins is inhibited, the remaining problems on the surface of the dispensing nozzle are solved, the reliability of analysis is improved and the cost is reduced cost and environmental load.
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experiment example
[0060] First, in order to improve the reliability of the analysis, the effect was verified using a flat substrate. The substrate used is silicon oxide (SiO) having a thickness of 10 nm in the outermost layer. 2 ) layer of the SUS substrate. The size of the substrate was 10 mm×10 mm×0.5 mm, and the measurement surface for verification of the effect used a surface of 10 mm×10 mm.
[0061] (Fabrication of a substrate to which PEG derivatives are adsorbed)
[0062] The experimental process flow is shown in image 3 middle.
[0063] Step 1. Formation of SiO on the SUS surface 2 Floor.
[0064] First, in order to remove the grease remaining on the surface of the stainless steel (SUS), degreasing is performed with an alkaline solvent. Then, using oxygen ( O 2) As a reactive gas, a DC magnetron sputtering apparatus using Ar as a discharge gas sputters Si. SiO 2 The film-forming conditions are as follows. The vacuum degree in the chamber is 5×10 -5 The set temperature of the...
Embodiment 1
[0098] In this example, the case where the same processing as in the experimental example is performed on the dispensing nozzle will be described. First, on the surface of a stainless steel dispensing nozzle, SiO was formed by sputtering in the same manner as in the experimental example. 2 Floor. The area being processed is figure 1 The end 105 of the dispensing nozzle and the region 104 that is immersed in the specimen. In this example, the outer diameter of the treated nozzle tip is 0.5 mm and the inner diameter is 0.3 mm, and SiO with a thickness of 10 nm is formed in the region of 10 mm at the tip. 2 Floor. The entire surface of the dispensing nozzle can also be treated, but the cost can be reduced by limiting the portion to the region to be treated by immersion.
[0099] Next, SiO will be formed 2 The surface of the dispensing nozzle of the layer was ultrasonically washed with ethanol for 15 minutes. At this time, in order not to damage the nozzle due to ultrasonic ...
Embodiment 2
[0103] Image 6In order to show a configuration example of the automatic analyzer of the present invention, the basic configuration will be described next. One or more sample containers 25 are arranged in the sample storage unit mechanism 1 . Here, an example of a sample disk mechanism that is a sample storage mechanism mounted in a disk-shaped mechanism will be described, but other forms of the sample storage mechanism may be those generally used in automatic analyzers. A specimen rack or specimen holder-like form. In addition, the sample referred to here refers to the solution to be tested used for the reaction in the reaction vessel, and may be a collected sample stock solution or a solution after processing such as dilution and pretreatment. The specimen in the specimen container 25 is drawn out by the specimen dispensing nozzle 27 of the specimen supply dispensing mechanism 2 and injected into a predetermined reaction container. The specimen dispensing nozzle was surfa...
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