Application of effective parts of common andrographis herbs

An effective part, the technology of Andrographis paniculata, applied in the field of application of the effective part of Andrographis paniculata, can solve the problems of difficult drug effect, undisclosed use of cancer chemoprevention, etc., and achieve the effect of easy operation and control, good chemopreventive effect, and high pharmacological activity

Active Publication Date: 2012-09-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although pharmacological experiments have proved that it can be used to treat inflammatory bowel disease, it has not been disclosed for the chemoprevention of cancer, and it is even more difficult to see its efficacy

Method used

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  • Application of effective parts of common andrographis herbs
  • Application of effective parts of common andrographis herbs
  • Application of effective parts of common andrographis herbs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1) Extraction: The whole plant of Andrographis paniculata was dried at 60°C for 5 hours to obtain the dried whole plant of Andrographis paniculata. Take 5Kg of dried whole herb of Andrographis paniculata, add 6 times the weight of the medicinal material in an ethanol aqueous solution containing 95% ethanol mass percentage (that is, ethanol aqueous solution 30Kg), and extract at 90°C under reflux, and the time of each extraction is 3h, and the total extraction 3 times (a total of 90Kg in ethanol aqueous solution), and combine the extracts;

[0060] 2) Extraction: Concentrate the extract obtained in step 1) to nearly dryness under reduced pressure to obtain 450g of thick extract, add 1Kg of water to dissolve, and then use 0.65Kg of petroleum ether with a boiling point of 60°C to 90°C each time for extraction and co-extraction 3 times, the extract was collected, and the extract was concentrated to obtain 200 g of the effective fraction of Andrographis paniculata.

[0061]...

Embodiment 2

[0065] 1) Extraction: The whole plant of Andrographis paniculata was dried at 60°C for 5 hours to obtain the dried whole plant of Andrographis paniculata. Take 5Kg of dried whole herb of Andrographis paniculata, add 10 times the weight of the medicinal material in an ethanol aqueous solution containing 95% ethanol by mass (i.e. 50Kg of ethanol aqueous solution), and extract at 100°C under reflux. The time of each extraction is 2h, and the total extraction 2 times (a total of 100Kg in ethanol aqueous solution), combined extracts;

[0066] 2) Extraction: Concentrate the extract obtained in step 1) to nearly dryness under reduced pressure to obtain 440g of thick extract, add 0.5Kg of water to dissolve, and then use 0.35Kg of petroleum ether with a boiling point of 60°C to 90°C each time for extraction. Extract 3 times, collect the extract, and concentrate the extract to obtain 180 g of the effective fraction of Andrographis paniculata.

[0067] The effective parts of Andrographi...

Embodiment 3

[0071] 1) Extraction: The whole plant of Andrographis paniculata was dried at 60°C for 5 hours to obtain the dried whole plant of Andrographis paniculata. Take 5Kg of dried whole herb of Andrographis paniculata, add an ethanol aqueous solution containing 95% ethanol mass percentage (that is, ethanol aqueous solution 40Kg) that is 8 times the weight of the medicinal material each time, and extract under reflux at 90°C. The time of each extraction is 3h, and the total extraction 3 times (a total of 120Kg in ethanol aqueous solution), combined extracts;

[0072] 2) Extraction: Concentrate the extract obtained in step 1) to nearly dryness under reduced pressure to obtain 470g of thick extract, add 2Kg of water to dissolve, and then use 0.8Kg of petroleum ether with a boiling point of 60°C to 90°C each time for extraction and co-extraction 3 times, the extract was collected, and the extract was concentrated to obtain 220 g of the effective fraction of Andrographis paniculata.

[0...

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Abstract

The invention discloses the application of effective parts of common andrographis herbs in preparing medicaments with a cancer chemoprevention function. Because effective parts of common andrographis herbs can induce expression of quinone reductase so as to achieve a cancer chemoprevention effect, the effective part of common andrographis herbs can be used for preparing medicaments with a cancer chemoprevention function. According to the invention, effective parts of common andrographis herbs are prepared into a tablet form, and pharmacological experiments prove that the prepared tablet has a strong quinone reductase inducing activity, therefore, the tablet can achieve a better cancer chemoprevention effect. The method for preparing effective parts of common andrographis herbs comprises the following steps: carrying out extraction on all herbs or leaves of andrographis paniculata by using an extraction solvent so as to obtain an extracting solution; concentrating the extracting solution, adding water into the concentrated extracting solution to dissolve, carrying out extraction on the dissolved solution by using a extraction solvent, collecting extract liquor, and then concentrating the extract liquor so as to obtain the effective parts of common andrographis herbs with stable properties and a high pharmacological activity; and the method is simple in preparation process, easy to implement, and easy to operate and control, therefore, the method has extremely broad application prospects.

Description

technical field [0001] The invention relates to the field of application and preparation of effective parts extracted from Andrographis paniculata, in particular to the application of the effective parts of Andrographis paniculata with cancer chemopreventive effect. Background technique [0002] According to the 2008 global cancer statistics released by the International Agency for Research on Cancer (IRAC), there were about 12.7 million new cancer cases and 7.6 million cancer deaths worldwide in 2008; among them, the new cancer cases and death cases in developing countries were respectively Accounted for 56% and 64%. On February 4, 2011, the American Cancer Society (ACS) published a global cancer statistics report on the statistics. Brawley of ACS pointed out in his comments that 35% of cancer risk factors are actually preventable. If effective measures are taken, 2.6 million cancer deaths in 2008 (about 7300 cases per day on average) could be avoided. [0003] The term c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61K9/20A61P35/00
Inventor 马忠俊袁永雷程林季龙卢娟
Owner ZHEJIANG UNIV
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