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35 results about "Quinone Reductases" patented technology
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NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.
Substituted quinoline and quinazoline inhibitors of quinone reductase 2
The present invention provides composition and methods of inhibiting quinone reductase 2 (QR2). The methods are useful in the treatment of malaria and autoimmune diseases. The compositions of the invention comprise quinoline and quinazoline derivatives. The invention also provides methods for inhibiting the activity of QR2 by contacting the enzyme with one or more compositions of the invention.
Owner:SERENEX INC
Cancer chemopreventive agents
Extracts prepared from red and high-pigment beetroots (Beta vulgaris L.) with a solvent, such as a water-containing solvent, possess antioxidant activity as demonstrated by a panel of assays. These extracts also have an ability to induce quinone reductase in Murine hepatoma cell (Hepa 1c1c7) cultured in vitro. Fractions purified from the active extracts also possess antioxidant activity and retain quinone reductase-inducing activity in the Hepa 1c1c7 cell line. The active extracts, purified by column, thin layer, and high-performance liquid chromatographic techniques, include betalains. A method of extracting a betalain includes steps of freeze-drying a source containing the betalain; grinding the freeze-dried source; and extracting the betalain from the ground source with the solvent. Additionally, the betalain extract can be isolated betalain components, such as by chromatography.
Owner:WISCONSIN ALUMNI RES FOUND
Anti-tumor application of tanshinone compound
InactiveCN101732294ALow costThe method is simple and reliableOrganic active ingredientsAntineoplastic agentsProstate cancerTumor vessel
The invention relates to an application of a tanshinone compound in preparing anti-tumor medicaments, and the prepared medicaments can resist tumors, such as brain tumors, lung cancer, liver caner, breast cancer, prostatic cancer, pancreatic cancer, cervical cancer, gastric cancer, esophagus cancer, and the like. Proved by experiments, the tanshinone compound is concentration-dependent to suppress the proliferation of tumor cells. The compound can obviously induce the expression of quinone reductase and obviously suppress the generation of tumor vessels, thus the compound can also be used for preparing cancer chemical prevention medicaments, anti-inflammatory medicaments and medicaments for suppressing the generation of the tumor vessels. Frequently used low-price reagents, such as alcohol, chloroform, methanol, silica gel, and the like, are used for separating tanshinone compound monomers from medicinal materials. The method is simple and reliable, has low cost and high efficiency, can be used for carrying out industrialized mass production and is beneficial to popularization and application. The tanshinone compound has a structural general formula disclosed in the specification.
Owner:ZHEJIANG UNIV
Application of effective parts of common andrographis herbs
The invention discloses the application of effective parts of common andrographis herbs in preparing medicaments with a cancer chemoprevention function. Because effective parts of common andrographis herbs can induce expression of quinone reductase so as to achieve a cancer chemoprevention effect, the effective part of common andrographis herbs can be used for preparing medicaments with a cancer chemoprevention function. According to the invention, effective parts of common andrographis herbs are prepared into a tablet form, and pharmacological experiments prove that the prepared tablet has a strong quinone reductase inducing activity, therefore, the tablet can achieve a better cancer chemoprevention effect. The method for preparing effective parts of common andrographis herbs comprises the following steps: carrying out extraction on all herbs or leaves of andrographis paniculata by using an extraction solvent so as to obtain an extracting solution; concentrating the extracting solution, adding water into the concentrated extracting solution to dissolve, carrying out extraction on the dissolved solution by using a extraction solvent, collecting extract liquor, and then concentrating the extract liquor so as to obtain the effective parts of common andrographis herbs with stable properties and a high pharmacological activity; and the method is simple in preparation process, easy to implement, and easy to operate and control, therefore, the method has extremely broad application prospects.
Owner:ZHEJIANG UNIV
Antioxidant dietary supplement and related method
ActiveUS20140147526A1Easy to manageMitigation of impairmentBiocideOrganic active ingredientsDietary supplementPhysiology
A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and / or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.
Owner:ACCESS BUSINESS GRP INT LLC
Selenium-containing compound and use thereof
ActiveCN106565718AOrganic chemistrySulfur/selenium/tellurium active ingredientsCytotoxicityQuinone Reductases
The invention relates to an application of a selenium-containing compound represented by formula I in the preparation of chemical prevention agents and treatment agents of cancers. Experiments confirm that the compound of the formula I can substantially induce the quinone reductase expression, have unobvious cytotoxicity under a quinone reductase induction active concentration condition (20 [mu]M), and can be used as an effective chemical prevention agent or treatment agent of cancers.
Owner:SHENZHEN F&S BIO TECH
Pyruvate enriched onion extract
InactiveUS20050037097A1Improves antioxidant activityEnhancing pyruvate contentBiocideSenses disorderOnion bulbGenus
Extracts of plants of the genus Allium, such as onion bulbs (Allium cepa), contain pyruvic acid and possess the ability to inhibit generation of organic free radicals, quench pre-formed free radicals, and to induce the activity of antioxidant enzymes such as quinone reductase, thus limiting damage due to aging such as cataracts.
Owner:ALBERTA RES COUNCIL INC
Compound having quinone reductase induced activity and preparation method thereof
ActiveCN103333217AHas quinone reductase inducing activityCytotoxic activitySteroidsAntineoplastic agentsOperabilityControllability
The invention discloses a compound having quinone reductase induced activity, which has a structure shown in Formula I. The compound has quinone reductase induced activity and can be used for preventing cancer. The invention also discloses a preparation method of the compound having quinone reductase induced activity, which is simple, reliable, easy to implement, high in operability and favorable in controllability. Formula I is shown in the specification.
Owner:ZHEJIANG UNIV
Salt responsive genes useful for generating salt resistant transgenic plants
ActiveUS20090217411A1Confer salt-resistanceLimited successBryophytesSugar derivativesInitiation factorPlant cell
The present invention relates to a transgenic plant comprising one or more plant cells transformed with exogenous nucleic acid encoding a Dunaliella salt-inducible or salt-responsive protein selected from the group consisting of elongation initiation factor 3 (eIF3), NADPH dependent quinone reductase (QOR), aldo-keto reductase (AKR), bifunctional aspartate kinase-homoserine reductase (AK-HSD) and mitochondrial import membrane translocase subunit (TIM9), or a fragment, homolog or variant thereof. The transgenic plant has increased tolerance to salt as compared to a corresponding non-transgenic plant. The present invention further relates to nucleic acids, vectors and constructs encoding the Dunaliella salt-inducible or salt-responsive proteins, and to a method of producing a transgenic plant having an increased tolerance to salt, a method of modifying a plant capacity to survive salt shock, and a method of modifying plant recovery after exposure to salt stress, by introducing the nucleic acids, constructs and / or vectors into one or more cells of the plant.
Owner:HAZERA GENETICS LTD +2
Construction method of Sul-de-Quinone Reductase gene vector and genetic engineering lactic acid bacteria strain of Sul-de-Quinone Reductase gene vector
InactiveCN102559732AEmission reductionBacteriaMicroorganism based processesBiotechnologyStaphylococcus lactis
The invention relates to a construction method of a Sul-de-Quinone Reductase gene vector (pMG36e-SQR-Myc) and a genetic engineering lactic acid bacteria strain of the Sul-de-Quinone Reductase gene vector and belongs to the technical field of organisms. The construction method comprises the following steps of: selecting pcDNA3.1-SQR-Myc eukaryotic expression plasmid as an initial raw material, connecting an SQR-Myc gene segment with a pMG36e vector and electrically-converting lactococcus lactis MG1363 and obtaining an efficient and stable expression. The construction method and the genetic engineering lactic acid bacteria strain have the beneficial effects that as selected lactic acid bacteria belongs to probiotics, the lactic acid bacteria can be taken as a safe micro-ecological preparation for directly feeding an animal; the lactic acid bacteria is habituated in an intestinal tract to achieve a normal physiological effect; and SQR lactic acid bacteria is expected to realize the function of degrading sulfide in the intestinal tract of the animal, so that the emission of sulfide in excrement is finally reduced.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
New hopane-type triterpene and preparation method and application thereof
The invention belongs to the technical filed of medicines, and relates to the preparation of three new hopane-type triterpenes and applications thereof. The new hopane-type triterpene saponins have the following structure shown in the specification. The new hopane-type triterpene compounds have quinone reductase induced activity, and can be used for development and application of anti-tumor drugsand tumor chemoprevention drugs.
Owner:SHENYANG PHARMA UNIVERSITY
Methods for improving cognitive function via modulation of quinone reductase 2
ActiveUS20170081669A1Reducing quinone reductase activityIncrease awarenessNervous disorderHydroxy compound active ingredientsCognitionActive agent
An active agent capable of reducing quinone reductase 2 activity, for use in improvement of cognition in a subject is provided. Such an active agent may be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A vector comprising a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 and a pharmaceutical composition comprising an active agent capable of reducing quinone reductase 2 activity or said vector are provided as well.
Owner:CARMEL HAIFA UNIV ECONOMIC
Compound for preventing cancers and preparation method thereof
ActiveCN103342728AHas quinone reductase inducing activityCytotoxic activitySteroidsAntineoplastic agentsCombinatorial chemistryQuinone Reductases
The invention discloses a compound for preventing cancers. The structure of the compound is shown in the formula II, wherein R represents Alpha-OH or Beta-OH. The compound has the quinone reductase inducing activity and can be used for preventing cancers. The invention further discloses a preparation method of the compound for preventing cancers. The method is simple, reliable, easy to implement, strong in operability and good in controllability.
Owner:ZHEJIANG UNIV
Protective bath foam capable of realizing rapid makeup removal and preparation method thereof
InactiveCN108553347ALong-lasting moisturizing effectPromote productionCosmetic preparationsMake-upLycopodiumGlutathione S-transferase
The invention discloses protective bath foam capable of realizing rapid makeup removal and a preparation method thereof. The protective bath foam capable of realizing rapid makeup removal contains 3-8wt% of selaginella lycopodium extract. According to the protective bath foam capable of realizing rapid makeup removal and the preparation method thereof disclosed by the invention, the selaginella lycopodium extract added into a formula of liquid shampoo is derived from all grass of selaginella lycopodium, is enriched in ferulic acid and other products, can achieve effects of scavenging free radicals, promoting generation of enzymes capable of eliminating free radicals, increasing activities of glutathione S-transferase and quinone reductase and inhibiting tyrosinase activity to regulate human physiological functions; with the adoption of a specific wetting agent, the bath foam can achieve a long-acting moisturizing effect, and the various components of the bath foam are effectively matched, so that the product is stable and obvious in cleansing care effect, has long-acting moisturizing and skin care effects, and can be used for a long time. The preparation method disclosed by the invention is simple in process, easy to operate, low in cost, high in efficiency and capable of easily realizing industrial production.
Owner:JIANGSU OUYALI DAILY COSMETIC
Methods for improving cognitive function via modulation of quinone reductase 2
ActiveUS10113171B2Reduced expression levelIncrease awarenessNervous disorderHydroxy compound active ingredientsCognitionActive agent
An active agent capable of reducing quinone reductase 2 activity, for use in improvement of cognition in a subject is provided. Such an active agent may be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A vector comprising a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 and a pharmaceutical composition comprising an active agent capable of reducing quinone reductase 2 activity or said vector are provided as well.
Owner:CARMEL HAIFA UNIV ECONOMIC
Selenium-containing compound and use thereof
The invention relates to an application of riboflavin selenium derivative shown in the description in preparing cancer chemopreventive agent. The compound is capable of significantly inducing the expression of quinone reductase and without significant cytotoxic effect under enzyme-induced activity concentration conditions, and can be used as effective cancer chemopreventive and therapeutic agent.
Owner:SHENZHEN F&S BIO TECH
Antioxidant dietary supplement and related method
ActiveUS9517249B2Mitigation of impairmentImprove antioxidant capacityOrganic active ingredientsVitamin food ingredientsDaphniphyllum calycinumDietary supplement
A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and / or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.
Owner:ACCESS BUSINESS GRP INT LLC
Application of effective parts of common andrographis herbs
ActiveCN102652762BChemopreventionStrong quinone reductase inducing activityPill deliveryAntineoplastic agentsPharmaceutical drugOncology
Owner:ZHEJIANG UNIV
Pharmaceutical composition and health food composition containing youngia denticulata extract, fraction thereof, or compound isolated therefrom as active ingredient for improving liver function
InactiveCN102186488BNon-cytotoxicOrganic active ingredientsDigestive systemCaffeoylquinic acidBiological activation
The present invention relates to a pharmaceutical composition for preventing cancer or improving liver function, containing Youngia denticulata extract, a fraction thereof, or one or more compounds as an active ingredient selected from a group consisting of chlorogenic acid, 3,5-di-O-caffeoylquinic acid, Youngiaside A, Youngiaside B, and Youngiaside C which are isolated therefrom. The Youngia denticulata extract, a fraction thereof, or a compound isolated therefrom according to the present invention enhances activation of detoxifying enzymes in the liver, including quinone reductase(QR) of a marker enzyme for preventing cancer and an antioxidant response element(ARE) of an antioxidant responsive factor. The extract, fraction, or compound is not cytotoxic as well protects the liver from liver injury induced by ethanol or acetaminophen. Therefore, the composition according to the present invention can be useful in medicinal products and health foods for preventing cancer or improving liver function.
Owner:KOREA INST OF SCI & TECH
Pharmaceutical composition and health food composition containing youngia denticulata extract, fraction thereof, or compound isolated therefrom as active ingredient for improving liver function
InactiveCN102186488ANon-cytotoxicOrganic active ingredientsDigestive systemCaffeoylquinic acidBiological activation
The present invention relates to a pharmaceutical composition for preventing cancer or improving liver function, containing Youngia denticulata extract, a fraction thereof, or one or more compounds as an active ingredient selected from a group consisting of chlorogenic acid, 3,5-di-O-caffeoylquinic acid, Youngiaside A, Youngiaside B, and Youngiaside C which are isolated therefrom. The Youngia denticulata extract, a fraction thereof, or a compound isolated therefrom according to the present invention enhances activation of detoxifying enzymes in the liver, including quinone reductase(QR) of a marker enzyme for preventing cancer and an antioxidant response element(ARE) of an antioxidant responsive factor. The extract, fraction, or compound is not cytotoxic as well protects the liver from liver injury induced by ethanol or acetaminophen.; Therefore, the composition according to the present invention can be useful in medicinal products and health foods for preventing cancer or improving liver function.
Owner:KOREA INST OF SCI & TECH
Quinone reductase 2 inhibitor compounds and uses thereof
PendingCN112867711AOrganic active ingredientsOrganic chemistryPharmaceutical medicineOrganic chemistry
Provided herein according to some embodiments is a compound of Formula (I): [Formula], or a pharmaceutically acceptable salt or prodrug thereof. Compositions comprising the compound, and uses thereof for inhibiting the activity of quinone reductase-2, as well as in methods of treatment, are also provided.
Owner:DUKE UNIV
Compound having quinone reductase induced activity and preparation method thereof
ActiveCN103333217BHas quinone reductase inducing activityCytotoxic activitySteroidsAntineoplastic agentsOperabilityControllability
The invention discloses a compound having quinone reductase induced activity, which has a structure shown in Formula I. The compound has quinone reductase induced activity and can be used for preventing cancer. The invention also discloses a preparation method of the compound having quinone reductase induced activity, which is simple, reliable, easy to implement, high in operability and favorable in controllability. Formula I is shown in the specification.
Owner:ZHEJIANG UNIV
New hopane-type triterpene and preparation method and application thereof
Owner:SHENYANG PHARMA UNIVERSITY
Quinone reductase 2 inhibitors for use as neuroprotective agents
Provided herein according to some embodiments is a method of treating acute neural injury in a subject in need thereof, comprising administering to the subject a compound of Formula I or Formula II. Also provided is a method of treating vascular dementia in a subject in need thereof, comprising administering to the subject a compound of Formula I or Formula II. Further provided is a method of treating CNS lupus in a subject in need thereof, comprising administering to the subject a compound of Formula I or Formula II.
Owner:DUKE UNIV
Methods for improving cognitive function via modulation of quinone reductase 2
ActiveUS20190119684A1Reduced expression levelIncrease awarenessNervous disorderHydroxy compound active ingredientsActive agentGene expression level
Owner:CARMEL HAIFA UNIV ECONOMIC
Compound for preventing cancers and preparation method thereof
ActiveCN103342728BHas quinone reductase inducing activityCytotoxic activitySteroidsAntineoplastic agentsOperabilityCombinatorial chemistry
The invention discloses a compound for preventing cancers. The structure of the compound is shown in the formula II, wherein R represents Alpha-OH or Beta-OH. The compound has the quinone reductase inducing activity and can be used for preventing cancers. The invention further discloses a preparation method of the compound for preventing cancers. The method is simple, reliable, easy to implement, strong in operability and good in controllability.
Owner:ZHEJIANG UNIV
Application of a kind of tea volatile essential oil in the preparation of anti-cancer health products or anti-cancer drugs
ActiveCN105559074BGood anticancer effectHigh recovery ratePharmaceutical delivery mechanismAntineoplastic agentsDistillationBlack tea
The invention belongs to the field of tea processing and discloses application of tea volatile essential oil to preparation of an anti-cancer health care product or an anti-cancer drug. The anti-cancer health care product or the anti-cancer drug refers to the health care product or the drug used for preventing or treating the cancer with a quinone reductase inductive effect. The tea volatile essential oil is prepared from tea leaves being a raw material through a simultaneous distillation-extraction method. The obtained tea volatile essential oil has a pleasant smell, can soothe the anxious emotion and has a certain anti-cancer effect; when the concentration of the volatile essential oil extracted from 6 types of tea including black tea, green tea, oolong tea, yellow tea, white tea and dark green tea is in the range of 3-30 micrograms / ml, quinone reductase can be induced to multiply, that is, the anti-cancer effect is achieved. Research results indicate that the tea volatile essential oil achieves the anti-cancer effect by inducing the quinone reductase, is a potential anti-cancer active substance and can be used for prepare the anti-cancer health care product or the anti-cancer drug.
Owner:SOUTH CHINA AGRI UNIV
Selenium-containing compound and use thereof
The invention relates to a selenium-containing compound represented by formula I, and an application of the compound of formula I in the preparation of a chemopreventive and therapeutic agent for cancers. The compound of the formula I can significantly induce the expression of purine reductase, and can be used as the effective chemopreventive and therapeutic agent for cancers.
Owner:SHENZHEN F&S BIO TECH
Selenium-containing compound and use thereof
InactiveCN106748941AEasy to prepareEasy to manufactureOrganic active ingredientsOrganic chemistrySelenium CompoundQuinone Reductases
The invention relates to application of a selenium-containing compound represented in a formula I (shown in the description) in the preparation of chemical prevention agents and treatment agents for cancers. Experiments prove that the compound represented in the formula I is capable of remarkably reducing the expression of quinone reductase, has no obvious cytotoxic effect under a concentration condition (20 mu M) with quinone reductase induction activity and can be taken as an effectively chemical prevention agent and treatment agent for the cancers.
Owner:武汉福山生物医药科技有限公司
Salt responsive genes useful for generating salt resistant transgenic plants
The present invention provides transgenic plants transformed with exogenous nucleic acid encoding a Dunaliella salt-inducible or salt-responsive protein selected from the group consisting of eukaryotic initiation factor 3 (eIF3) subunit, NADPH dependent quinone reductase (QOR), aldo-keto reductase (AKR), bifunctional aspartate kinase-homoserine reductase (AK-HSD) and mitochondrial import membrane translocase subunit (TIM9), or a fragment, homolog or variant thereof. The transgenic plants have increased tolerance to salt as compared to corresponding non-transgenic plants. The present invention further provides nucleic acids, constructs and vectors encoding the Dunaliella salt-inducible or otherwise salt-responsive proteins, and to a method of producing transgenic plants having an increased tolerance to salt, a method of modifying plant capacity to survive salt shock, and a method of modifying plant recovery after exposure to salt stress, by introducing the nucleic acids, constructs and / or vectors into one or more cells of the plant.
Owner:HAZERA GENETICS LTD +2
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