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35 results about "Quinone Reductases" patented technology

NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.

Cancer chemopreventive agents

Extracts prepared from red and high-pigment beetroots (Beta vulgaris L.) with a solvent, such as a water-containing solvent, possess antioxidant activity as demonstrated by a panel of assays. These extracts also have an ability to induce quinone reductase in Murine hepatoma cell (Hepa 1c1c7) cultured in vitro. Fractions purified from the active extracts also possess antioxidant activity and retain quinone reductase-inducing activity in the Hepa 1c1c7 cell line. The active extracts, purified by column, thin layer, and high-performance liquid chromatographic techniques, include betalains. A method of extracting a betalain includes steps of freeze-drying a source containing the betalain; grinding the freeze-dried source; and extracting the betalain from the ground source with the solvent. Additionally, the betalain extract can be isolated betalain components, such as by chromatography.
Owner:WISCONSIN ALUMNI RES FOUND

Application of effective parts of common andrographis herbs

The invention discloses the application of effective parts of common andrographis herbs in preparing medicaments with a cancer chemoprevention function. Because effective parts of common andrographis herbs can induce expression of quinone reductase so as to achieve a cancer chemoprevention effect, the effective part of common andrographis herbs can be used for preparing medicaments with a cancer chemoprevention function. According to the invention, effective parts of common andrographis herbs are prepared into a tablet form, and pharmacological experiments prove that the prepared tablet has a strong quinone reductase inducing activity, therefore, the tablet can achieve a better cancer chemoprevention effect. The method for preparing effective parts of common andrographis herbs comprises the following steps: carrying out extraction on all herbs or leaves of andrographis paniculata by using an extraction solvent so as to obtain an extracting solution; concentrating the extracting solution, adding water into the concentrated extracting solution to dissolve, carrying out extraction on the dissolved solution by using a extraction solvent, collecting extract liquor, and then concentrating the extract liquor so as to obtain the effective parts of common andrographis herbs with stable properties and a high pharmacological activity; and the method is simple in preparation process, easy to implement, and easy to operate and control, therefore, the method has extremely broad application prospects.
Owner:ZHEJIANG UNIV

Compound having quinone reductase induced activity and preparation method thereof

ActiveCN103333217AHas quinone reductase inducing activityCytotoxic activitySteroidsAntineoplastic agentsOperabilityControllability
The invention discloses a compound having quinone reductase induced activity, which has a structure shown in Formula I. The compound has quinone reductase induced activity and can be used for preventing cancer. The invention also discloses a preparation method of the compound having quinone reductase induced activity, which is simple, reliable, easy to implement, high in operability and favorable in controllability. Formula I is shown in the specification.
Owner:ZHEJIANG UNIV

Construction method of Sul-de-Quinone Reductase gene vector and genetic engineering lactic acid bacteria strain of Sul-de-Quinone Reductase gene vector

The invention relates to a construction method of a Sul-de-Quinone Reductase gene vector (pMG36e-SQR-Myc) and a genetic engineering lactic acid bacteria strain of the Sul-de-Quinone Reductase gene vector and belongs to the technical field of organisms. The construction method comprises the following steps of: selecting pcDNA3.1-SQR-Myc eukaryotic expression plasmid as an initial raw material, connecting an SQR-Myc gene segment with a pMG36e vector and electrically-converting lactococcus lactis MG1363 and obtaining an efficient and stable expression. The construction method and the genetic engineering lactic acid bacteria strain have the beneficial effects that as selected lactic acid bacteria belongs to probiotics, the lactic acid bacteria can be taken as a safe micro-ecological preparation for directly feeding an animal; the lactic acid bacteria is habituated in an intestinal tract to achieve a normal physiological effect; and SQR lactic acid bacteria is expected to realize the function of degrading sulfide in the intestinal tract of the animal, so that the emission of sulfide in excrement is finally reduced.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES

Protective bath foam capable of realizing rapid makeup removal and preparation method thereof

The invention discloses protective bath foam capable of realizing rapid makeup removal and a preparation method thereof. The protective bath foam capable of realizing rapid makeup removal contains 3-8wt% of selaginella lycopodium extract. According to the protective bath foam capable of realizing rapid makeup removal and the preparation method thereof disclosed by the invention, the selaginella lycopodium extract added into a formula of liquid shampoo is derived from all grass of selaginella lycopodium, is enriched in ferulic acid and other products, can achieve effects of scavenging free radicals, promoting generation of enzymes capable of eliminating free radicals, increasing activities of glutathione S-transferase and quinone reductase and inhibiting tyrosinase activity to regulate human physiological functions; with the adoption of a specific wetting agent, the bath foam can achieve a long-acting moisturizing effect, and the various components of the bath foam are effectively matched, so that the product is stable and obvious in cleansing care effect, has long-acting moisturizing and skin care effects, and can be used for a long time. The preparation method disclosed by the invention is simple in process, easy to operate, low in cost, high in efficiency and capable of easily realizing industrial production.
Owner:JIANGSU OUYALI DAILY COSMETIC

Application of effective parts of common andrographis herbs

ActiveCN102652762BChemopreventionStrong quinone reductase inducing activityPill deliveryAntineoplastic agentsPharmaceutical drugOncology
The invention discloses the application of effective parts of common andrographis herbs in preparing medicaments with a cancer chemoprevention function. Because effective parts of common andrographis herbs can induce expression of quinone reductase so as to achieve a cancer chemoprevention effect, the effective part of common andrographis herbs can be used for preparing medicaments with a cancer chemoprevention function. According to the invention, effective parts of common andrographis herbs are prepared into a tablet form, and pharmacological experiments prove that the prepared tablet has a strong quinone reductase inducing activity, therefore, the tablet can achieve a better cancer chemoprevention effect. The method for preparing effective parts of common andrographis herbs comprises the following steps: carrying out extraction on all herbs or leaves of andrographis paniculata by using an extraction solvent so as to obtain an extracting solution; concentrating the extracting solution, adding water into the concentrated extracting solution to dissolve, carrying out extraction on the dissolved solution by using a extraction solvent, collecting extract liquor, and then concentrating the extract liquor so as to obtain the effective parts of common andrographis herbs with stable properties and a high pharmacological activity; and the method is simple in preparation process, easy to implement, and easy to operate and control, therefore, the method has extremely broad application prospects.
Owner:ZHEJIANG UNIV

Selenium-containing compound and use thereof

The invention relates to a selenium-containing compound represented by formula I, and an application of the compound of formula I in the preparation of a chemopreventive and therapeutic agent for cancers. The compound of the formula I can significantly induce the expression of purine reductase, and can be used as the effective chemopreventive and therapeutic agent for cancers.
Owner:SHENZHEN F&S BIO TECH
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