Aqueous chlorhexidine iodine sterilizing spray and preparation method thereof

Abstract

The invention relates to aqueous chlorhexidine iodine sterilizing spray and a preparation method thereof. The spray comprises the following materials by weight: 0.1-2% of chlorhexidine iodine, 1-30% of solubilizer, 0.5-5% of cosolvent and the balance of water, and is prepared by dissolving the chlorhexidine iodine, the solubilizer and the coslovent with appropriate amount of water under ultrasonic treatment, adding the rest of water until the sum of the prescription is 100%, mixing, and filling into a spray bottle. The inventive spray has the advantages of no iodine odor, yellow-staining, toxicity, teratogenecity and skin / mucous membrane irritation, low available concentration, strong sterilizing ability, wide antibacterial spectrum, simple preparation process, and easy popularization.

Description

technical field [0001] The invention relates to a disinfectant spray, in particular to an aqueous solution type chlorhexidine iodine disinfectant spray and a preparation method thereof. Background technique [0002] Disinfecting the skin can directly and effectively block the invasion of external microorganisms, and is an important part of controlling infection. Disinfectants are a kind of medical and health equipment commonly used in clinical practice. With the development of medicine and the changes in disinfection requirements such as surgical field disinfection, war wound disinfection, mucous membrane disinfection, and hand disinfection, more and more new disinfectants are emerging and used Applied clinically. [0003] Chlorhexidine iodine is a molecular bond complex formed by the reaction of iodine and chlorhexidine. The imino group and iminoamide group in the chlorhexidine iodine complex structure form a delocalized high-density electron structure. 3 - Participate i...

AI Technical Summary

Problems solved by technology

Chlorhexidine iodine is insoluble in water, Chinese patent CN 101310727 A uses alcohol as the dissolving medium of chlorhexidine iodine, has prepared chlorhexidine iodine alcoholic disinfectant, but because of its alcohol content up to 30%~80%, the product Strong irritation, poor stability, not suitable for disinfection of mucous membranes or damaged skin, the scope of application is limited

Chinese patent CN 1126523 C dilutes the available iodine and prepares a compound iodine disinfectant liquid containing a certain amount of available iodine, which is essentially a mixed solution of iodine and chlorhexidine, rather than a chlorhexidine-iodine complex solution, The bactericidal effect is general, and it uses cotton balls or cotton swabs as the carrier of chlorhexidine iodine disinfectant, which is not only inconvenient to use, but also may cause secondary pollution due to improper operation, which cannot meet the requirements of rapid, safe and efficient disinfection