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Combination of related ingredients with vasodilation effect in traditional Chinese medicine for lowering blood pressure

A technology for dilating blood vessels and effects, applied in the field of compatibility of related ingredients with dilating blood vessels, can solve problems such as difficult quality control, complicated compound ingredients, restrictions on the promotion and use of blood pressure-lowering traditional Chinese medicines, and achieve the effect of avoiding side effects

Inactive Publication Date: 2016-03-23
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although traditional Chinese medicine compound recipes have achieved good clinical results in treating hypertension and its complications, the traditional Chinese medicine compound recipes are complex in composition and difficult to control in quality, which limits the promotion and use of blood pressure-lowering Chinese medicine in a wider range.
Although the quality of active ingredients of traditional Chinese medicine with a single ingredient is controllable, the therapeutic effect is far behind that of compound Chinese medicine

Method used

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  • Combination of related ingredients with vasodilation effect in traditional Chinese medicine for lowering blood pressure
  • Combination of related ingredients with vasodilation effect in traditional Chinese medicine for lowering blood pressure
  • Combination of related ingredients with vasodilation effect in traditional Chinese medicine for lowering blood pressure

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Composition (active ingredient type=2) preparation

[0021] Method a: combine the two active ingredients in a weight ratio of 1:1 to obtain a compatibility.

[0022] Method b: On the premise that the total amount is constant, the lowest effective dose of each active ingredient is used as the benchmark, during which each ingredient is decreased or increased by 20%, and finally expanded to the extreme of high dose.

[0023] Using the rat thoracic aortic ring model and the SHR model, the best compatibility ratio was screened out.

Embodiment 2

[0024] Embodiment 2: preparation of composition (active component type≤6)

[0025] Method a: Combination of 3 ingredients. 3 kinds of active ingredients and 5 dosage levels, design 3 factors 5 levels table [L 25 (5 6 )], the composition of different dosage ratios, using the rat thoracic aortic vascular ring model, SHR model, to screen out the best compatibility ratio.

[0026] Method b: Combination of 4 ingredients. 4 kinds of active ingredients and 5 dosage levels, design 4 factors 5 levels table [L 25 (5 6 )], the composition of different dosage ratios, using the rat thoracic aortic vascular ring model, SHR model, to screen out the best compatibility ratio.

[0027] Method c: 5 ingredient combinations. 5 kinds of active ingredients and 5 dosage levels, according to the orthogonal experiment design 5 factors 5 levels table [L 25 (5 6 )], the composition of different dosage ratios, using the rat thoracic aortic vascular ring model, SHR model, to screen out the best com...

Embodiment 3

[0029] Embodiment 3: Pinoresinol diglucoside, rhynchophylline, puerarin, and cassia anthraquinone were used to prepare the composition according to Example 1, and the in vitro thoracic aortic vascular ring experiment in rats showed that the vasodilation effect was as follows:

[0030] Table 1 Vasodilation effect after combination of pinoresinol diglucoside, rhynchophylline, puerarin, and cassia anthraquinone in pairs (n=6)

[0031]

[0032]

[0033] As can be seen from the above table, pinoresinol diglucoside: rhynchophylline=1:2; pinoresinol diglucoside: puerarin=1:1; pinoresinol diglucoside: cassia anthraquinone=4:1; rhynchophylline: Puerarin=4:1; rhynchophylline:cassia anthraquinone=4:1; puerarin:cassia anthraquinone=4:1 is the best compatibility ratio.

[0034] The best compatibility screened out was given to SHR rats by intragastric administration after grouping, and the systolic blood pressure of the tail artery of the rats was detected every week for a total of fo...

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Abstract

The invention relates to the related ingredient combination with the function of relaxing vessels in traditional Chinese medicine for reducing blood pressure which is commonly used clinically. The invention utilizes modern traditional Chinese medicine theory and provides a related ingredient combination with definite ingredient, controllable quality and precise curative effect by animal model tests for reducing blood pressure. The related ingredient combination can be used for relaxing vessels, treating hypertension and improving hypertension complication. The commonly used traditional Chinese medicine relates to eucommia ulmoides, rhizoma gastrodiae, rhizoma chuanxiong, salviae miltiorrhizae, Astragalus mongholicus, root of kudzu vine, uncaria, radix stephaniae tetrandrae, red flower, radix scutellariae, selfheal, semen cassiae, dogbane leaf, hawthorn, radix achyranthis bidentatae, sophora flower, pseudo-ginseng, motherwort, chrysanthemum, lotus plumule, evodia, cape jasmine fruit, epimedium and caltrop which are included in Chinese Pharmacopoeia (2010 edition). The related ingredients are active ingredients which are extracted from single traditional Chinese medicine. Each traditional Chinese medicine provides one or several active ingredients. The combination study comprises the following steps of combining 2-6 active ingredients with different mechanisms in proportion, screening by utilizing rat thoracic aorta vascular rings and spontaneous hypertension rat models and determining the optimum combination proportion.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to the compatibility of related ingredients in blood pressure lowering traditional Chinese medicines which have the effect of dilating blood vessels. The compatibilized composition can be used to relax blood vessels, treat hypertension and improve hypertension complications. Background technique [0002] Hypertension and cardiovascular and cerebrovascular diseases related to hypertension are one of the main killers that endanger public health, and their incidence is increasing year by year. Effective prevention and treatment of them has become a public health problem of common concern worldwide. Although the current antihypertensive drugs can effectively control blood pressure, due to the different mechanisms of blood pressure rise in patients, a single drug is often unable to control it, and a combination of drugs is required. After combined medication, each antihyperte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61K36/482A61K31/7048A61P9/12A61K31/437A61K31/4965A61K31/352A61K31/7034
Inventor 许激扬卞筱泓赵刚刚周恒源王旻
Owner CHINA PHARM UNIV
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