Heat resisting protective agent of bivalent live vaccine against highly pathogenic porcine reproductive and respiratory syndrome-pseudorabies and preparation method thereof

A technology for respiratory syndrome and heat-resistant protective agents, which is applied in antiviral agents, non-active ingredients of polymer compounds, and pharmaceutical formulations, and can solve problems such as unsatisfactory protective performance, unfavorable mass production, and high production costs, and achieve formulation components And preparation method is simple, realizes mass production, the effect of low cost

Inactive Publication Date: 2012-10-17
GUANGDONG DAHUANONG ANIMAL HEALTH PRODS +1
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Problems solved by technology

These heat-resistant freeze-drying protective agents have defects such as too complicated formula, hig

Method used

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  • Heat resisting protective agent of bivalent live vaccine against highly pathogenic porcine reproductive and respiratory syndrome-pseudorabies and preparation method thereof
  • Heat resisting protective agent of bivalent live vaccine against highly pathogenic porcine reproductive and respiratory syndrome-pseudorabies and preparation method thereof
  • Heat resisting protective agent of bivalent live vaccine against highly pathogenic porcine reproductive and respiratory syndrome-pseudorabies and preparation method thereof

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Embodiment Construction

[0022] The heat-resistant protective agent of the highly pathogenic porcine reproductive and respiratory syndrome-porcine pseudorabies dual live vaccine of the present invention and its preparation method will be further described in detail below through specific implementation examples.

[0023] A heat-resistant protective agent for highly pathogenic porcine reproductive and respiratory syndrome-porcine pseudorabies dual live vaccine, which is prepared according to the following steps:

[0024] 1) High-temperature sterilization: Dissolve gelatin, soybean peptone, sucrose, trehalose, polyvinylpyrrolidone, and mannitol in water for injection. The amount of water for injection is 1 / 2 of the total water for injection. Sterilize at high temperature for 10-20 minutes, and the conditions for high-temperature sterilization are preferably 115°C for 15 minutes;

[0025] 2) Sterilization by microporous membrane filtration: Glycine and vitamin E are dissolved in water for injection, the ...

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Abstract

The invention discloses a heat resisting protective agent of a bivalent live vaccine against highly pathogenic porcine reproductive and respiratory syndrome-pseudorabies, and a preparation method thereof. The heat resisting protective agent of the bivalent live vaccine against highly pathogenic porcine reproductive and respiratory syndrome-pseudorabies is prepared by the following materials by weight: 0.8 to 1.2% of gelatin, 4 to 6% of soybean peptone, 0.5 to 1.5% of glycine, 3 to 5% of sucrose, 2 to 3% of trehalose, 1 to 2% of polyvinyl pyrrolidone, 0.5 to 1% of mannitol, 0.1 to 0.2% of vitamin E and the rest being injection water. The preparation method comprises steps of high-temperature sterilization, filtration sterilization through a microporous membrane and mixing. The heat resisting protective agent of the bivalent live vaccine against highly pathogenic porcine reproductive and respiratory syndrome-pseudorabies of the invention reduces damage on virus activity caused by various physical and chemical factors during the freeze drying process, provides good protection and effectively solves the problems that a conventional protective agent of live vaccine needs refrigerated transport and storage is inconvenient.

Description

technical field [0001] The invention relates to the technical field of veterinary biological products, in particular to a heat-resistant protective agent for highly pathogenic porcine reproductive and respiratory syndrome-pseudorabies dual live vaccine and a preparation method thereof. Background technique [0002] Porcine reproductive and respiratory syndrome, also known as PRRS, is a highly contagious infectious disease of pigs caused by porcine reproductive and respiratory syndrome virus. The virus can infect pigs of different ages, breeds and sexes, especially for pregnant sows and piglets less than 1 month old. The disease is mainly characterized by miscarriage, stillbirth, weak fetus, mummified fetus, dyspnea, sepsis and high mortality in piglets. Highly pathogenic porcine blue-ear disease is an acute and highly lethal infectious disease caused by a mutant strain of porcine reproductive and respiratory syndrome virus. The clinical manifestations are high body temperat...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/18A61K47/26A61K47/36A61K47/32A61K47/22A61P31/14A61P31/22A61K39/245A61K39/12
Inventor 陈瑞爱田克恭练炳洲遇秀琳邵定勇翟新验邓小熊周智林绮萍曲萍
Owner GUANGDONG DAHUANONG ANIMAL HEALTH PRODS
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