35results about How to "High degree of aging resistance" patented technology

The invention provides a porcine Japanese encephalitis live vaccine heat-resistant lyophilized protective agent. The protective agent comprises the following components in percentage by weight: 1.0-1.4% of gelatin, 9-11% of sucrose, 9-11% of trehalose, 0.15-0.35% of polyvinylpyrrolidone, 0 .3-0.8% of sorbitol, 0.3-0.8% of mannitol, 0.1-0.2% of PEG-6000, and 0.01-0.02% of tween-80, the pH value of the protective agent is 7.5, and the components are added with water to be dissolved and sterilized at high temperature to obtain the protective agent.The lyophilized protective agent disclosed by the invention is mixed with a porcine Japanese encephalitis live vaccine virus solution, and freeze-drying is carried out to obtain a lyophilized vaccine. The heat-resistant lyophilized protective agent disclosed by invention is simple in formulation, easy in preparation, suitable for large-scale production, has good protection efficacy for vaccines, and can ensure that the vaccines can be preserved for 10 days effectively at the normal temperature, even at the temperature of 37 DEG C, and preserved for 24 months at the temperature of 2-8 DEG C.

The invention belongs to the technical field of biology, and particularly relates to a high-pathogenicity porcine reproductive and respiratory syndrome heat-resistant protective agent live vaccine anda preparation method thereof. The heat-resistant protective agent live vaccine is high in aging resistance, the loss rate after storage for 7 days at 37 DEG C does not exceed 1 titer, and after the vaccine is stored for 18 months at 2-8 DEG C, the titer of the vaccine is reduced a little, so that the problems of energy waste and storage inconvenience caused by the fact that the vaccine needs to be subjected to frozen storage in the transportation and storage processes are effectively solved; through a high-pressure sterilization cabinet used in the preparation method, by arranging a shell, aleakage tank and a reaction tank, automatic weighing of raw materials of a heat-resistant protective agent is effectively achieved, rapid dissolving and uniform mixing of all the raw materials are achieved, meanwhile, the interior of the reaction tank can be automatically heated and pressurized, and finally the heat-resistant protective agent is prepared; and the preparation process is comprehensively and mechanically carried out, the cleanliness is relatively high, the influence of human factors is reduced, and the efficiency is relatively high.

The invention relates to a heat-resistant freeze-drying protective agent for newcastle disease live vaccines and a preparation method. The heat-resistant freeze-drying protective agent for the newcastle disease live vaccines specifically comprises the following components in percentage by weight: 1-2% of sodium carboxymethylcellulose, 2-8% of xylo-oligosaccharide, 1-3% of sorbitol, 1-3 %of polyvinylpyrrolidone, 0.5-0.8% of glutamine, 0.1-0.5% of sodium selenite and the balance of water for injection. The technical problem that the newcastle disease live vaccines cannot be stored and transported for a long time at the temperature of 2 DEG C to 8 DEG C is solved by the protective agent provided by the invnetion.

The invention relates to a freeze-drying protective additive which is composed of 1 to 2% of NZ-Amine AS, 0.1 to 0.2% of monosodium glutamate, 5 to 10% of saccharose, 1 to 2% of M199, 0.1 to 0.3% of trehalose, 8 to 15% of hydrolyzed gelatin, and the balance of water. The freeze-drying protective additive is used for preparing a freeze-dried pseudorabies vaccine. A heat-resisting protective agent can minimize the damage of various physical and chemical factors of a product to virus activity during sub-packaging and freezing-drying processes, greatly reduces the titer loss of the virus before and after freezing and drying and keeps the loss of being not greater than 0.2 titer. A heat-resisting protective agent live vaccine is high in degree of resistance to aging, the loss ratio of the virus kept for 10 days under a condition of 37 DEG C is not greater than 0.5 titer; the heat-resisting protective agent live vaccine can be stored for 24 months at 2 to 8 DEG C, the titer of the vaccine is reduced a little, so that the problem that the vaccine in general transporting and storing needs strict cold chain condition, which leads to energy waste and inconvenient storage, can be solved effectively.

The invention relates to a heatproof freeze-drying protecting agent for recombined pseudorabies virus vaccines. The heatproof freeze-drying protecting agent comprises, by weight, 4-8% of trehalose, 0-3% of cane sugar, 0.2-0.8% of sorbitol, 1-3% of polyvinylpyrrolidone K-30, 4-7% of soybean protein isolate, 0.5-1% of wheat proteolysis product and the balance injection water. The invention further provides a preparation method of the heatproof freeze-drying protecting agent for the recombined pseudorabies virus vaccines. The heatproof freeze-drying protecting agent is simple in formula, easy to prepare and suitable for mass production, has the advantages of high vaccine stability, prolonged vaccine shelf life and the like, and does not contain gelatin and animal source ingredients. Safety of the vaccines is high when the protecting agent is applied to the vaccines.

The invention relates to a heat-resisting freeze-dried protective agent for a live vaccine for chicken infectious bursal diseases and a preparation method for the heat-resisting freeze-dried protective agent. The heat-resisting freeze-dried protective agent for the live vaccine for chicken infectious bursal diseases is prepared from the following components in percentage by weight: 2 to 3 percentof sodium carboxy methyl cellulose, 3 to 6 percent of xylo-oligosaccharide, 2 to 3 percent of polyvinylpyrrolidone, 0.5 to 0.8 percent of glutamine, 0.1 to 0.5 percent of sodium selenite, 0.01 to 0.05 percent of potassium chloride and the balance of water for injection. By the heat-resisting freeze-dried protective agent, the technical problem that the live vaccine for chicken infectious bursal diseases cannot be stored and transported for long time at the temperature of between 2 and 8 DEG C is solved, production process is simplified, and production cost is reduced.

The invention discloses an imitation stone thermal insulating decoration board and a making process thereof, relating to a technology for producing a thermal insulating decoration board for a wall. The thermal insulating decoration board is completely made from magnesium oxide, magnesium chloride, real stone particles and other organic materials which are combined into a main frame, and a phenolic foam board is attached in the main frame as a thermal insulating layer; and the parts are assembled in a separated-module manner, fastened through mortise and riveted through a metal anchor. The components of the raw material comprise magnesium oxide, magnesium chloride solution, sodium hexametaphosphate, melamine formaldehyde resin, waterproof agent, purifying agent, silicon powder, real stone particles and glass fiber. The steps of confecting magnesium chloride solution, confecting organic material paste, molding, curing / de-molding and painting are performed to obtain an imitation stone thermal insulating decoration board. The product of the invention is incombustible and superior in heat resistance, enhances the strength, hardness and aging-resistant performance of the product; moreover, the construction period is short, the labor intensity is small and the comprehensive maintenance cost is low. The product avoids the problems that engineering construction is often subjected to bulge, cracking, drop and water seepage, the thermal insulating layer shrinks and deforms, the outer layer cracks at high temperature and the like.

The invention relates to a newcastle disease and avian infectious bronchitis bigeminal live vaccine heat-resisting freeze-drying protective agent and a preparation method. The newcastle disease and avian infectious bronchitis bigeminal live vaccine heat-resisting freeze-drying protective agent provided by the invention comprises the following components: 1-2% of sodium carboxymethylcellulose, 2-8% of xylo-oligosaccharide, 1-3% of sorbitol, 0.5-0.8% of sodium glutamate, 0.1-0.5% of sodium selenite and the balance of water for injection. The heat-resisting freeze-drying protective agent provided by the invention solves the problem that the newcastle disease and avian infectious bronchitis bigeminal live vaccine can not be stored for a long time and transported at 2-8 DEG C.