35results about How to "High degree of aging resistance" patented technology

The invention provides a porcine Japanese encephalitis live vaccine heat-resistant lyophilized protective agent. The protective agent comprises the following components in percentage by weight: 1.0-1.4% of gelatin, 9-11% of sucrose, 9-11% of trehalose, 0.15-0.35% of polyvinylpyrrolidone, 0 .3-0.8% of sorbitol, 0.3-0.8% of mannitol, 0.1-0.2% of PEG-6000, and 0.01-0.02% of tween-80, the pH value of the protective agent is 7.5, and the components are added with water to be dissolved and sterilized at high temperature to obtain the protective agent.The lyophilized protective agent disclosed by the invention is mixed with a porcine Japanese encephalitis live vaccine virus solution, and freeze-drying is carried out to obtain a lyophilized vaccine. The heat-resistant lyophilized protective agent disclosed by invention is simple in formulation, easy in preparation, suitable for large-scale production, has good protection efficacy for vaccines, and can ensure that the vaccines can be preserved for 10 days effectively at the normal temperature, even at the temperature of 37 DEG C, and preserved for 24 months at the temperature of 2-8 DEG C.

The invention belongs to the technical field of biology, and particularly relates to a high-pathogenicity porcine reproductive and respiratory syndrome heat-resistant protective agent live vaccine anda preparation method thereof. The heat-resistant protective agent live vaccine is high in aging resistance, the loss rate after storage for 7 days at 37 DEG C does not exceed 1 titer, and after the vaccine is stored for 18 months at 2-8 DEG C, the titer of the vaccine is reduced a little, so that the problems of energy waste and storage inconvenience caused by the fact that the vaccine needs to be subjected to frozen storage in the transportation and storage processes are effectively solved; through a high-pressure sterilization cabinet used in the preparation method, by arranging a shell, aleakage tank and a reaction tank, automatic weighing of raw materials of a heat-resistant protective agent is effectively achieved, rapid dissolving and uniform mixing of all the raw materials are achieved, meanwhile, the interior of the reaction tank can be automatically heated and pressurized, and finally the heat-resistant protective agent is prepared; and the preparation process is comprehensively and mechanically carried out, the cleanliness is relatively high, the influence of human factors is reduced, and the efficiency is relatively high.

The invention relates to a lyophilized vaccine for swine encephalitis B. The lyophilized vaccine consists of Japanese encephalitis virus serving as an antigen, and a protective agent, wherein the protective agent is prepared from the following substances in percentage by mass: 2.4-4% of NZ-amine, 0.3-0.5% of mono-potassium glutamate, 16-20% of sucrose, 6-20% of lactoalbumin hydrolysate, 1-1.6% of gelatin and the balance of water. According to the vaccine disclosed by the invention, the used lyophilized protective agent is made from raw materials which are low in cost, and the operation is simple, so that the vaccine can be produced in a large scale. After the vaccine prepared from the protective agent is stored for 24 months at the temperature of 2-8 DEG C, the potency of the vaccine is not smaller than 10<5.7>TCID50 / head (Chinese Standard), so that the storage life of the vaccine is prolonged effectively.

The invention relates to a warp-knitted polyester glass fiber three-dimensional slope protection soil fixation grating and a preparation method thereof, and in particular relates to a multi-grid grating formed by weaving polyester fiber yarns and glass fiber yarns and a preparation method thereof. Transverse gratings of the grating are formed by arranging glass fiber yarns and polyester fiber yarns; longitudinal gratings of the grating are glass fiber yarns; joints of transverse gratings and longitudinal gratings of grids are bound by polyester wires; after the grating is heated, the glass fiber yarns of the transverse gratings of the grids are upwards bent and protruded from binding points on two sides to form a three-dimensional state of the grating; and a solidification layer formed by waterproof adhesive emulsion is arranged on the surface of the grating. The grating in the preparation method is easy in production and manufacture and high in efficiency; in a construction paving process, the stability of the length and the width of the grating is good; a large area of gratings are paved; the construction difficulty is low; the warp-knitted polyester glass fiber three-dimensional slope protection soil fixation grating is used on the surface of a slope body, and a slope fixing effect is good; and even if the grating is corroded by rainwater for a long time and is immersed in water, the grating still has enough strength.

The invention relates to a heat-resistant freeze-drying protective agent for a recombinant pseudorabies virus vaccine, which is made of the following components in terms of weight percentage: 2-3% gelatin, 1-2% polyvinylpyrrolidone K-301-2%, and 0-0 trehalose 4%, sucrose 2-5%, mannitol 0.1-0.5%, astragalus polysaccharide 0-0.5%, glycine 1-1.5%, arginine 0-1%, bovine serum albumin 0-1%, and the balance is injection use water. The invention also provides a preparation method of the recombinant pseudorabies virus vaccine heat-resistant freeze-drying protectant. The heat-resistant freeze-drying protective agent for recombinant pseudorabies virus vaccine of the invention can prolong the storage time of the vaccine in a relatively high temperature environment, and its preparation method is simple, which is convenient for production and application.

The invention relates to a heat-resistant freeze-drying protective agent for newcastle disease live vaccines and a preparation method. The heat-resistant freeze-drying protective agent for the newcastle disease live vaccines specifically comprises the following components in percentage by weight: 1-2% of sodium carboxymethylcellulose, 2-8% of xylo-oligosaccharide, 1-3% of sorbitol, 1-3 %of polyvinylpyrrolidone, 0.5-0.8% of glutamine, 0.1-0.5% of sodium selenite and the balance of water for injection. The technical problem that the newcastle disease live vaccines cannot be stored and transported for a long time at the temperature of 2 DEG C to 8 DEG C is solved by the protective agent provided by the invnetion.

The invention relates to a freeze-drying protective additive which is composed of 1 to 2% of NZ-Amine AS, 0.1 to 0.2% of monosodium glutamate, 5 to 10% of saccharose, 1 to 2% of M199, 0.1 to 0.3% of trehalose, 8 to 15% of hydrolyzed gelatin, and the balance of water. The freeze-drying protective additive is used for preparing a freeze-dried pseudorabies vaccine. A heat-resisting protective agent can minimize the damage of various physical and chemical factors of a product to virus activity during sub-packaging and freezing-drying processes, greatly reduces the titer loss of the virus before and after freezing and drying and keeps the loss of being not greater than 0.2 titer. A heat-resisting protective agent live vaccine is high in degree of resistance to aging, the loss ratio of the virus kept for 10 days under a condition of 37 DEG C is not greater than 0.5 titer; the heat-resisting protective agent live vaccine can be stored for 24 months at 2 to 8 DEG C, the titer of the vaccine is reduced a little, so that the problem that the vaccine in general transporting and storing needs strict cold chain condition, which leads to energy waste and inconvenient storage, can be solved effectively.

The invention relates to a heatproof freeze-drying protecting agent for recombined pseudorabies virus vaccines. The heatproof freeze-drying protecting agent comprises, by weight, 4-8% of trehalose, 0-3% of cane sugar, 0.2-0.8% of sorbitol, 1-3% of polyvinylpyrrolidone K-30, 4-7% of soybean protein isolate, 0.5-1% of wheat proteolysis product and the balance injection water. The invention further provides a preparation method of the heatproof freeze-drying protecting agent for the recombined pseudorabies virus vaccines. The heatproof freeze-drying protecting agent is simple in formula, easy to prepare and suitable for mass production, has the advantages of high vaccine stability, prolonged vaccine shelf life and the like, and does not contain gelatin and animal source ingredients. Safety of the vaccines is high when the protecting agent is applied to the vaccines.

The invention relates to a porcine reproductive and respiratory syndrome live vaccine heat-resistant freeze-drying protective agent and a preparation method thereof. The heat-resistant freeze-drying protective agent is mixed by the raw materials based on weight percentage: 1-2% of gelatin, 4-6% of trehalose, 1-2% of tryptone, 1-2% of trypticase, 1-2% of polyvinylpyrrolidone, 0.164% of dipotassiumphosphate, 0.052% of monopotassium phosphate, 1% of sorbic alcohol, 1% of sodium glutamate, 1% of arginine salt and the balance of water. The preparation method comprises the steps of: preparing the materials into two mixed solution, respectively preparing in a mixing way by means of degerming to prepare a heat-resistant freeze-drying protective agent, mixing according to the proportion of the protective agent to the virus-resistant raw material as 1:1, performing split charging, and drying in a freezing way. Before drying in a freezing way, the virus loss rate is low, a freeze-drying productis high in ageing-resistant degree, and the virus is invariable in content after the freeze-drying product is preserved at the temperature of 2-8 DGE C for 24 months. After the invention is used, thetechnical neck bottle that the porcine reproductive and respiratory syndrome live vaccine can be preserved and transported under the condition of -15 DEG C is solved.

The invention relates to a heat-resisting freeze-dried protective agent for a live vaccine for chicken infectious bursal diseases and a preparation method for the heat-resisting freeze-dried protective agent. The heat-resisting freeze-dried protective agent for the live vaccine for chicken infectious bursal diseases is prepared from the following components in percentage by weight: 2 to 3 percentof sodium carboxy methyl cellulose, 3 to 6 percent of xylo-oligosaccharide, 2 to 3 percent of polyvinylpyrrolidone, 0.5 to 0.8 percent of glutamine, 0.1 to 0.5 percent of sodium selenite, 0.01 to 0.05 percent of potassium chloride and the balance of water for injection. By the heat-resisting freeze-dried protective agent, the technical problem that the live vaccine for chicken infectious bursal diseases cannot be stored and transported for long time at the temperature of between 2 and 8 DEG C is solved, production process is simplified, and production cost is reduced.

The invention discloses an imitation stone thermal insulating decoration board and a making process thereof, relating to a technology for producing a thermal insulating decoration board for a wall. The thermal insulating decoration board is completely made from magnesium oxide, magnesium chloride, real stone particles and other organic materials which are combined into a main frame, and a phenolic foam board is attached in the main frame as a thermal insulating layer; and the parts are assembled in a separated-module manner, fastened through mortise and riveted through a metal anchor. The components of the raw material comprise magnesium oxide, magnesium chloride solution, sodium hexametaphosphate, melamine formaldehyde resin, waterproof agent, purifying agent, silicon powder, real stone particles and glass fiber. The steps of confecting magnesium chloride solution, confecting organic material paste, molding, curing / de-molding and painting are performed to obtain an imitation stone thermal insulating decoration board. The product of the invention is incombustible and superior in heat resistance, enhances the strength, hardness and aging-resistant performance of the product; moreover, the construction period is short, the labor intensity is small and the comprehensive maintenance cost is low. The product avoids the problems that engineering construction is often subjected to bulge, cracking, drop and water seepage, the thermal insulating layer shrinks and deforms, the outer layer cracks at high temperature and the like.

The invention relates to a newcastle disease and avian infectious bronchitis bigeminal live vaccine heat-resisting freeze-drying protective agent and a preparation method. The newcastle disease and avian infectious bronchitis bigeminal live vaccine heat-resisting freeze-drying protective agent provided by the invention comprises the following components: 1-2% of sodium carboxymethylcellulose, 2-8% of xylo-oligosaccharide, 1-3% of sorbitol, 0.5-0.8% of sodium glutamate, 0.1-0.5% of sodium selenite and the balance of water for injection. The heat-resisting freeze-drying protective agent provided by the invention solves the problem that the newcastle disease and avian infectious bronchitis bigeminal live vaccine can not be stored for a long time and transported at 2-8 DEG C.