The present application relates to the technical field of compound synthesis, and in particular to a preparation method of
amino acid-based
lactam, comprising: A) reacting an alpha-
amino acid and an alpha-hydroxy acid ester in a first
solvent under the action of a first catalyst to obtain N-(hydroxyacyl)-
amino acid ester; B) reacting the N-(hydroxyacyl)-amino acid ester in a second
solvent under the action of a second catalyst to obtain amino acid-based
lactam with a structure shown in Formula I; in Formula I, R1 and R2 are independently selected from one of
hydrogen, a C1-C4 straight-chain or branched-chain
aliphatic hydrocarbon group, a substituted or unsubstituted C6-C30
aryl group, a protected amino group, a protected carboxyl group, a protected hydroxyl group and a protected sulfydryl group; and the
protecting group is one of an alkoxycarbonyl group, an
acyl group and an
alkyl group. The present application can solve the problems in the existing
lactam synthesis process, such as high
raw material risk, complicated process, and difficult product purification.