The invention discloses a bio-based degradable meal box material and a preparation method thereof. The bio-based degradable meal box material is prepared from the following raw materials: straw powder, a hydrophobic auxiliary agent, a lubricant, a reactive auxiliary agent, a biodegradable high-molecular compound, an antioxidant, a grafting treatment auxiliary agent, a toughening compatible auxiliary agent and an antibacterial agent. The bio-based degradable meal box material disclosed by the invention can be effectively biodegraded, can be degraded by 72.3% within 60 days and can be completelydegraded within 144 days, and white pollution can be effectively solved. The straw powder is subjected to gelation, plasticization, grafting, oxidation resistance, coupling and antibacterial treatment to obtain the degradable meal box material with excellent performance, the problems that an existing straw powder bio-based degradable material is large in water absorption and moisture absorption and prone to powder removal can be solved, and the comprehensive performance is improved; the material has good antibacterial performance, the antibacterial performance is improved by adding an antibacterial agent into the material, and the modified chitosan has the best antibacterial effect.