A high-efficiency intelligent high-side electronic load switch with wide voltage adaptability comprises a power supply module, a core control module, a self-boosting module, a voltage detection module, a current detection module and a switching module. The core control module is used for signal acquisition, information processing and storage and logic control; firstly, the core control module receives an external switch control input signal and detection signals output by the current detection module and the voltage detection module and processes and analyzes monitoring data according to an internally stored program to control the switching module to complete corresponding actions; secondly, the core control module provides a PWM control signal for the self-boosting module. The voltage detection module and the current detection module are used for detecting the real-time operating voltage and current of the switching module and transmitting data to the core control module for processing and analysis. The self-boosting module is used for providing a driving voltage for a switching tube in the switching module. The switching module is used for executing the on-off actions of a load. The high-efficiency intelligent high-side electronic load switch is wide in operating voltage range, high in operating frequency, high in efficiency, low in loss, safe, reliable and programmable.