The invention discloses a thermoacoustic refrigeration device of an automobile. The thermoacoustic refrigeration device of the automobile comprises an automobile exhaust and waste heat heater, an acoustic capacitance tube, a heat buffer tube, an injection pump, a thermoacoustic backheating end cooler, a thermoacoustic heat regenerator, a diversion cooler, a feedback tube, a direct current-proofing spring diaphragm, a resonant cavity, a resonant cavity diaphragm, a resonant cavity, a vessel, a precooler, a refrigeration heat regenerator, a vessel cold side heat exchanger, a vessel hot end heat exchanger, a trachea, an air storeroom and a regulating valve. The invention is characterized in that the thermoacoustic refrigeration device not only can reduce the temperature of the tail gas discharged into atmosphere, but also can avoid the greenhouse effect and damage on ozonosphere caused by leakage of refrigerating fluid of the existing automobile, effectively protect the environment, can greatly save energy consumption of the automobile, and avoids the problems of insufficient power and the like of small-displacement automobiles caused by turning on automotive air conditionings.