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Preparation method of Salvia miltiorrhiza soft capsule

A technology for soft capsules and salvia miltiorrhiza, applied in the field of medicine, can solve the problem of not paying attention to the stability of salvianolic acid B, and achieve the effects of improving bioavailability, improving dissolution, and overcoming difficulties in dissolution

Inactive Publication Date: 2012-11-14
沈阳长秀医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the salvia miltiorrhiza preparation prepared by this invention does not contain fat-soluble ingredients, which are one of the active ingredient groups of salvia miltiorrhiza, and does not pay attention to the stability of salvianolic acid B in the preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of tanshinone extract and total phenolic acid extract from Danshen.

[0025] Take 200kg of Danshen decoction pieces, add 2000L of 85% ethanol solution, soak at 80°C for 1.5 hours, collect the extract, recover the ethanol, concentrate and dry to obtain tanshinone extract containing tanshinone ⅡA; add 1600L of water to the dregs, soak at 80°C After 1 hour, collect the extract, let it cool, put it directly on the column through macroporous resin D-101 (300L), wash with water until the effluent is colorless, and then use 20% ethanol solution (700L) to elute at a flow rate of 1.0 BV / h , collect the eluate, spray dry after evaporating ethanol to obtain the total phenolic acid extract of Salvia miltiorrhiza containing salvianolic acid B.

[0026] The content of tanshinone Ⅱ A in the tanshinone extract was determined to be 8.7% by high performance liquid chromatography. The yield of salvia miltiorrhiza extract was 1.2%, the total phenolic acid content of ...

Embodiment 2

[0027] Example 2 Preparation of tanshinone extract and total phenolic acid extract from Salvia miltiorrhiza.

[0028] Take 200kg of Danshen decoction pieces, add 1600L of 85% ethanol solution, soak twice at 75°C for 1 hour each time, collect the extract, recover the ethanol, concentrate and dry to obtain a tanshinone extract containing tanshinone ⅡA; add 2000L of water to the dregs, Soak twice at 75°C for 1 hour each time, collect the extracts and combine them, let them cool, and put them directly on the column through macroporous resin D-101 (340L), wash with water until the effluent is colorless, then use 30% ethanol solution ( 550L) was eluted at a flow rate of 1.2 BV / h, the eluate was collected, and after the ethanol was evaporated, it was spray-dried to obtain the total phenolic acid extract of Salvia miltiorrhiza containing salvianolic acid B.

[0029] The content of tanshinone Ⅱ A in the tanshinone extract was determined to be 9.6% by high performance liquid chromatogra...

Embodiment 3

[0030] Example 3 Preparation of Tanshinone Extract and Total Phenolic Acid Extract from Salvia Miltiorrhiza.

[0031] Take 500kg of Danshen decoction pieces, add 4500L of 90% ethanol solution, soak twice at 75°C for 1.5 hours each time, collect the extracts and combine them, recover the ethanol, concentrate and dry to obtain the tanshinone extract containing tanshinone ⅡA; add 3000L of water to the dregs , soaked twice at 75°C for 1 hour each time, collected the extracts and combined them, concentrated them properly and let them cool, put them on the column with macroporous resin D-101 (800L), washed them with water until the effluent was colorless, and then used 40% The ethanol solution (1000L) was eluted at a flow rate of 1.2 BV / h, the eluate was collected, and the ethanol was evaporated and then dried by microwave to obtain the total phenolic acid extract of Salvia miltiorrhiza containing salvianolic acid B.

[0032] The content of tanshinone Ⅱ A in the tanshinone extract w...

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PUM

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Abstract

The invention provides a preparation method of a Salvia miltiorrhiza soft capsule, comprising the following steps of: completely mixing Salvia miltiorrhiza extract with glycerine and polyethylene glycol 400 so that liposoluble constituents such as tanshinone II A are dissolved in a liquid substrate so as to achieve certain solubilization and improve the biological availability of liposoluble constituents of Salvia miltiorrhiza. In the preparation process of the Salvia miltiorrhiza soft capsule, a method for preparing Salvia miltiorrhiza water-soluble component extract is provided, a macroporous resin separation technology is adopted, and ethanol solution is concentrated, atomized and dried after elution; in the obtained extract, the total salvianolic acid compounds account for more than 60% of total solid, wherein the content of salvianolic acid compound danshinolic acid B is between 45% and 60%, and the content of danshensu is controlled between 10% and 20%. The content of danshensu is controlled while the yield of salvianolic acids is improved so that the proportion of the main active ingredient danshinolic acid B is obviously improved. The preparation method is safe and efficient, low-toxic and environmentally-friendly, can satisfy the requirement of industrial production, and has wide and practical application value.

Description

technical field [0001] The invention relates to a preparation method of soft capsules containing salvia miltiorrhiza extract, belonging to the technical field of medicine. Background technique [0002] Salvia miltiorrhiza is also known as red ginseng, purple salvia miltiorrhiza, red root and so on. Its active ingredients mainly include two categories: fat-soluble non-quinone pigment compounds, such as tanshinone IIA, tanshinone IIB, cryptotanshinone and its isomers, and water-soluble phenolic acids, such as salvianolic acid B, protocatechualdehyde, and salvia miltiorrhiza Su and so on. Among them, tanshinone Ⅱ A can increase coronary blood flow, improve myocardial metabolic disorder caused by hypoxia, thereby improving the ability of myocardial hypoxia tolerance; it can significantly prolong the hypoxia tolerance time of mice, reduce myocardial damage caused by hypoxia, and at the same time, improve Cardiac contractility, promote myocardial regeneration; also has a signifi...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/48A61P9/10
Inventor 房丽娜王艳戴凌松刘晓吉
Owner 沈阳长秀医药有限公司
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