Apremilast For The Treatment Of Sarcoidosis

A technology for sarcoidosis, nodules, applied in the field of pharmaceutical compositions and dosing regimens, capable of solving difficult standard therapy, treatment, etc.

Inactive Publication Date: 2012-11-14
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, many cases of sarcoidosis are refractory to standard therapies

Method used

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  • Apremilast For The Treatment Of Sarcoidosis
  • Apremilast For The Treatment Of Sarcoidosis
  • Apremilast For The Treatment Of Sarcoidosis

Examples

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Embodiment Construction

[0017] The present invention provides methods of treating, controlling or preventing sarcoidosis comprising administering a PDE4 inhibitor to a patient in need of such treatment, managing or preventing. In one embodiment, the sarcoidosis is acute sarcoidosis. In other embodiments, the sarcoidosis is chronic sarcoidosis.

[0018] In one embodiment, the sarcoidosis includes, but is not limited to: cardiac sarcoidosis, skin sarcoidosis, hepatic sarcoidosis, oral sarcoidosis, pulmonary sarcoidosis, nervous system sarcoidosis, sinonasal nodules sarcoidosis, Lofgren's syndrome, lupus peritoneum, uveitis, or chronic cutaneous sarcoidosis.

[0019] In one embodiment, the sarcoidosis is selected from the group consisting of: cardiac sarcoidosis, cutaneous sarcoidosis, hepatic sarcoidosis, oral sarcoidosis, pulmonary sarcoidosis, nervous system sarcoidosis, nasal sinus sarcoidosis , Lofgren's syndrome, lupus pereptoid, uveitis, or chronic cutaneous sarcoidosis.

[0020] In one embodi...

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Abstract

Provided herein are methods of treating, preventing and/or managing sarcoidosis by the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-4-acetylaminoisoindolin-l,3-dione, alone or in combination with other therapeutics.

Description

[0001] This application claims priority to US Provisional Application No. 61 / 262,907, filed November 19, 2009, which is hereby incorporated by reference in its entirety. 1. Field of invention [0002] The present invention relates to the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-4-acetylaminoisoindole alone or in combination with other therapies A method for the treatment, prevention and / or management of sarcoidosis using phenoline-1,3-diones. The invention also provides pharmaceutical compositions and dosing regimens. 2. Background of the invention [0003] Sarcoidosis is a disease of unknown etiology. Sarcoidosis is characterized by the presence of granulomas in one or more organ systems. The most common sites of involvement are the lungs and lymph nodes in the mediastinum and hilar regions. However, sarcoidosis is a systemic disease and various organ systems or tissues may be the source of primary or concomitant clinical manifestatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4035A61P17/00A61P37/00A61P43/00
CPCC07D209/48A61K31/573A61K31/4035A61K45/06A61P17/00A61P35/00A61P37/00A61P43/00A61K2300/00
Inventor J·B·泽尔迪斯
Owner CELGENE CORP
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