Composite acne removing lipid nanoparticle emulsion and preparation method thereof

A lipid nanoparticle and nanoparticle technology, which is used in drug combinations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of large odor, inconvenience to use, and difficulty in entering the deep layers of the skin for effective ingredients, so as to achieve small odor and suppress acne. Bacillus, the effect of improving the effect of acne

Active Publication Date: 2012-11-21
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Vitex spica extract is a dark brown oily substance with a very strong odor and is insoluble in water. The solubility of tetrahydropiperine in water is also less than 0.1%, which is inconvenient to use in cosmetics
Moreover, the average particle size of traditional cosmetic creams and emulsions is greater than 200nm, and it is quite difficult for active ingredients to penetrate deep into the skin.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of compound acne-removing lipid nanoparticle emulsion, comprising the steps of:

[0021] A. Take by weighing 1.2g Vitex paniculata extract, 1.2g Centella asiatica extract, 0.6g tetrahydropiperine to form a composite acne-removing active substance;

[0022] B. Weigh 0.5g poloxamer 188, 0.5g poloxamer 407, 5.0g polyglycerol-10 myristate, 30.0g monoglyceride stearate, and carry out the compound anti-acne active substance obtained in step A Mix, then heat to 75°C, and stir with a propeller stirrer at a speed of 600 rpm for 10 minutes to obtain a liquid oil phase;

[0023] C. Weigh 61.0 g of distilled water at 85° C., mix the distilled water with the liquid oil obtained in step B to obtain a mixed solution, and stir the mixed solution evenly with a propeller stirrer at a speed of 600 rpm;

[0024] D. Pour the mixed solution obtained in step C into a high-pressure homogenizer for emulsification, control the pressure at 70 MPa, and the temperature at 85° ...

Embodiment 2

[0033] A preparation method of compound acne-removing lipid nanoparticle emulsion, comprising the steps of:

[0034] A. Weigh 1.0g Vitex paniculata extract, 1.6g Centella asiatica extract, 0.1g tetrahydropiperine to form a compound acne-removing active substance;

[0035] B. Weigh 0.25g poloxamer 188, 0.25g poloxamer 407, 1.0g polyglycerol-10 myristate, 3.0g monoglyceride stearate, and carry out the compound anti-acne active substance obtained in step A. Mix, then heat to 85°C, and stir with a propeller stirrer at a speed of 600 rpm for 10 minutes to obtain a liquid oil phase;

[0036] C. Weigh 92.8g of distilled water at 75°C, mix the distilled water with the liquid oil obtained in step B to obtain a mixed solution, and stir the mixed solution evenly with a propeller stirrer at a speed of 600 rpm;

[0037] D. Pour the mixed solution obtained in step C into a high-pressure homogenizer for emulsification, control the pressure at 150 MPa, and the temperature at 75° C., and circ...

Embodiment 3

[0046] A preparation method of compound acne-removing lipid nanoparticle emulsion, comprising the steps of:

[0047] A. Take by weighing 2.5g Vitex paniculata extract, 5.0g Centella asiatica extract, 0.5g tetrahydropiperine to form a compound acne-removing active substance;

[0048] B. Weigh 1.0g poloxamer 188, 3.0g poloxamer 407, 4.0g polyglycerol-10 myristate, 16g monoglyceride stearate, and mix them with the compound acne active substance obtained in step A , then heated to 82°C, and stirred with a propeller stirrer at a speed of 600 rpm for 10 minutes to obtain a liquid oil phase;

[0049] C. Weigh 68.0 g of distilled water at 82°C, mix the distilled water with the liquid oil obtained in step B to obtain a mixed solution, and stir the mixed solution evenly with a propeller agitator at a speed of 600 rpm;

[0050] D. Pour the mixed solution obtained in step C into a high-pressure homogenizer for emulsification, control the pressure at 120 MPa, and the temperature at 85° C....

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Abstract

The invention relates to a composite acne removing lipid nanoparticle emulsion and a preparation method of the composite acne removing lipid nanoparticle emulsion. The emulsion contains 1.0-8.0% by mass percentage of composite acne removing active matters which are made up of a vitex agnus-castus extract, a herba centellae extract and tetrahydropiperine according to the mass ratio of (2-10) to (2-16) to 1. The method comprises the steps of weighing the composite acne removing active matters to prepare a liquid oil phase; preparing the liquid state oil phase and distilled water into a mixed solution, circularly homogenizing the mixed solution with pressure of 70-150MPa and temperature of 75-85 degrees centigrade by a high pressure homogenizer, and obtaining the composite acne removing lipid nanoparticle emulsion. The invention has the following advantages: the composite acne removing lipid nanoparticle emulsion simultaneously loaded with three active matters including the vitex agnus-castus extract, the herba centellae extract and tetrahydropiperine can be prepared; the obtained composite acne removing lipid nanoparticle emulsion is good in stability, remarkable in acne removing effect, light in colour, little in peculiar smell, and is conveniently added into the formulas of the cosmetics via a cooling distribution.

Description

technical field [0001] The invention relates to the technical field of preparation of lipid nanoparticles, in particular to a composite acne-removing lipid nanoparticle emulsion and a preparation method thereof. Background technique [0002] Acne (commonly known as acne), during puberty, the increase in androgen levels stimulates the sebaceous glands, making the sebum secretion function abnormally active. Excessive sebum cannot be discharged in time, and stasis forms fat plugs in the hair follicles, which is the so-called acne. The lipolytic enzyme produced by acne bacilli can decompose sebum into free fatty acids, which can destroy the hair follicle wall, make the content of the hair follicle enter and stimulate the dermis and the tissues around the hair follicle, cause inflammation around the pilosebaceous gland, and lead to a series of acne symptoms. Acne seriously affects the appearance and life, so acne-removing cosmetics are favored by more and more young consumers. H...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/49A61K8/06A61Q19/00A61P17/10
Inventor 蒋丽刚
Owner PROYA COSMETICS
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