Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of Houttuynoid E in medicine for treating acute renal failure

A technology for acute renal failure and drugs, which is applied in the direction of drug combinations, pharmaceutical formulas, organic active ingredients, etc., to achieve obvious therapeutic effects

Inactive Publication Date: 2013-07-17
艾韦特(溧阳)医药科技有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few clinical drugs that have obvious effects on improving renal blood perfusion disorder and reducing renal tissue damage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Houttuynoid E in medicine for treating acute renal failure
  • Application of Houttuynoid E in medicine for treating acute renal failure
  • Application of Houttuynoid E in medicine for treating acute renal failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of compound Houttuynoid E tablet involved in the present invention:

[0014] Take 20 grams of compound Houttuynoid E, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0015] Embodiment 2: the preparation of compound Houttuynoid E capsule involved in the present invention:

[0016] Get 20 grams of compound Houttuynoid E, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

[0018] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0019] Experimental example 1 Therapeutic effect of Houttuynoid E on rats with acute renal failure

[0020] (1) Experimental method

[0021] Rat animal model of acute renal failure induced by intramuscular injection of glycerol. 60 healthy male SD rats of 180~220g were selected and randomly divided into 5 groups: sham operation group (intramuscular injection of normal saline); model group (intramuscular injection of glycerol); Houttuynoid E Ⅰ group (0.3 mg / Kg)); Houttuynoid E Group Ⅱ (0.6 mg / Kg)); Houttuynoid E group Ⅲ (1.2 mg / Kg)), the rats in each group were injected with normal saline or Houttuynoid E by tail vein immediately after glycerol modeling, and administered again after 12 and 24 hours .

[0022] (2) Observation indicators

[0023] After the last administration of Houttuynoid E or normal saline, 60 rats were put into metabolic cages to collect urine for 24 hours. Six hours after the urine retention, they were anesthetized by intraperitoneal injection of 4% chlor...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to new medicinal application of Houttuynoid E, namely application of Houttuynoid E in preparation of a medicine for treating acute renal failure. The application of Houttuynoid E in preparation of the medicine for treating acute renal failure provided by the invention is disclosed firstly. The skeleton type belongs to new skeleton type, and the activity of Houttuynoid E on inhibition of acute renal failure is unexpectedly strong; and the probability that any revelation is provided by other compounds does not exist, Houttuynoid E has the excellent substantive features, and Houttuynoid E obviously has a remarkable progress when being used for preventing acute renal failure.

Description

technical field [0001] The present invention relates to the field of medicinal chemistry. Specifically, the present invention relates to a new medical application of Houttuynoid E, that is, the application of Houttuynoid E in the preparation of medicines for treating acute renal failure. Background technique [0002] Acute Renal Failure (ARF) is a clinical syndrome caused by a variety of reasons, which can be seen in patients from various clinical departments. It has a high incidence and often brings serious consequences. ) sharp decline in mental function, clinical manifestations of acute oliguria (urine output <400mLPd) or anuria (urine output <100mLPd), obstacles in the excretion of nitrogen metabolites in the body, rapid azotemia, water and electrolytes, acid-base Balance disorder, and cause the corresponding dysfunction of the system of the whole body. The main factors causing acute renal failure are the sharp reduction of renal blood flow, as well as the oxidat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P13/12
Inventor 冯怡黄晨吴俊华
Owner 艾韦特(溧阳)医药科技有限公司