Temperature uniformizer integrating multiple chromatographic columns with different lengths and diameters

Abstract

The invention discloses a temperature uniformizer integrating multiple chromatographic columns with different lengths and diameters. An upper metal heat conducting block and a lower metal heat conducting block are linked with each other through a hinge and respectively provided with multiple upper semicircular chromatographic column grooves and multiple lower semicircular chromatographic column grooves, wherein one or more groups of metal inner casings are respectively placed in each upper semicircular chromatographic column groove and each lower semicircular chromatographic column groove, one or more groups of metal outer casings are sheathed outside each metal inner casing, the inner diameter of the metal inner casing is the same as the outer diameter of a body of the chromatographic column placed in the metal inner casing, the outer diameter of the metal outer casing is greater than or equal to that of a head of the chromatographic column, and the length of the upper semicircular chromatographic column groove and the lower semicircular chromatographic column groove is greater than that of the chromatographic column. The temperature uniformizer is reasonable in structure, and can be used for improving the heat conducting efficiency of a thermotank of a high performance liquid chromatograph (HPLC), shortening the heat balance time of the thermotank, and maintaining the consistency, stability and uniformity of the working temperature of the chromatographic columns.

Description

Technical field [0001] The invention relates to a temperature homogenizer in which multiple chromatographic columns of different lengths and column diameters are integrated into a chromatographic column thermostat of a high-performance liquid chromatograph. Background technique [0002] Multidimensional high performance liquid chromatography uses two or more columns with different properties to separate components in complex samples. In the detection of multidimensional high performance liquid chromatography, the sample is pre-separated in the first-dimensional chromatographic column, and then all or part of the pre-separated components are selectively transferred to another or more different types of chromatograms. Further separation in the column. Multidimensional high performance liquid chromatography technology has the function of pretreatment of samples, separation and enrichment, which can improve the separation ability of high performance liquid chromatographs, eliminate ...

AI Technical Summary

Problems solved by technology

The above-mentioned factors that cause the inconsistent, unstable and uneven working temperature of the chromatographic column can affect the accuracy and repeatability of the multidimensional HPLC analysis

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