The invention discloses a 
hybrid nuclear power plant fault diagnosis method, belonging to the technical field of fault diagnosis. The method comprises a step of collecting operation parameters in a diagnosed 
system and transmitting the parameters to an established mechanism 
simulation model, a step of calculating a residual error on real-
time data and a corresponding parameter obtained by 
simulation model calculation, a step of judging a result or 
result set of a fault type when the calculated residual error exceeds a 
limit value, a step of adding a diagnosis result into the 
simulation model to carry out fault 
verification, a step of selecting a part of operation parameters obtained by measurement as evaluation parameters, and determining a 
data analysis model of a 
Mahalanobis distance function for fault degree evaluation, a step of calculating a 
Mahalanobis distance value, and establishing evaluation curves of different fault 
modes, and a step of calculating the 
Mahalanobis distance function distance value of actual fault data by using the operation data of the diagnosed 
system after failure, and establishing evaluation curves under different fault degrees to carry out match analysis to complete the 
quantitative assessment of a fault degree.