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Flurbiprofen axetil micro-emulsion gel preparation and preparation method thereof

A technology of flurbiprofen axetil and microemulsion gel, which is applied in anti-inflammatory agents, pharmaceutical formulations, aerosol delivery, etc. It can solve the problems of dose influence, low viscosity, and long-term drug retention, etc. Achieve the effects of easy operation, simple process, and improved drug efficacy and use efficiency

Inactive Publication Date: 2013-02-13
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although microemulsions have the above-mentioned many advantages in transdermal drug delivery, their low viscosity affects their application in external transdermal drug delivery preparations. When microemulsions are used alone, it is difficult to make the drug stay on the skin surface. Longer time, so the dose administered will be affected, which often affects the actual application of the drug

Method used

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  • Flurbiprofen axetil micro-emulsion gel preparation and preparation method thereof
  • Flurbiprofen axetil micro-emulsion gel preparation and preparation method thereof
  • Flurbiprofen axetil micro-emulsion gel preparation and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0025] formula:

[0026] Preparation of flurbiprofen axetil microemulsion gel

[0027]

[0028] At room temperature, ethyl oleate, propylene glycol and Tween-80 were mixed according to the above proportions respectively, then flurbiprofen axetil was added, stirred, and water was added to stir and mix to obtain a transparent microemulsion. Then 2g of the gel matrix is ​​added to the microemulsion and swelled for 24 hours to obtain the flurbiprofen axetil microemulsion gel preparation.

[0029] The gel matrix is ​​Carbomer 940.

[0030] The particle size diagram of ethyl oleate is shown in figure 1 , in the figure, the three curves represent three scans at 6.78nm respectively.

[0031] Adopt following method, the flurbiprofen axetil sponge slow-release patch that obtains is carried out transdermal test, the results are shown in Figure 5 ,Depend on Figure 5 It can be seen that the transdermal effect is good:

[0032] Transdermal test method: Place the mouse skin flatly...

Embodiment 2

[0034] Preparation of flurbiprofen axetil microemulsion gel

[0035]

[0036]

[0037] At room temperature, ethyl oleate, propylene glycol and Tween-80 were mixed according to the above proportions respectively, then flurbiprofen axetil was added, and then water was added under the condition of stirring to prepare a transparent microemulsion. Then 2g of the gel matrix was added to the microemulsion solution and swelled for 24 hours to obtain the flurbiprofen axetil microemulsion gel preparation.

[0038] The blue line represents the scanning curve for the first time at 5.47nm in Example 2, and the red line represents the particle size diagram of the second ethyl oleate in Example 2 at 5.47nm. figure 2 , in the figure, the three curves represent the third scan curve at .47nm respectively.

[0039] The gel matrix is ​​Carbomer 940.

Embodiment 3

[0041] Preparation of flurbiprofen axetil microemulsion gel

[0042]

[0043] At room temperature, ethyl oleate, propylene glycol and Tween-80 are fully mixed respectively according to the above proportions, then flurbiprofen axetil is added, and water is added under stirring to prepare a transparent microemulsion. Then add 4g of gel matrix into the microemulsion solution, and swell for 24 hours to obtain the flurbiprofen axetil microemulsion gel preparation.

[0044] The particle size diagram of flurbiprofen axetil is shown in image 3 , the three lines represent three scan curves at 5.47 nm.

[0045] The gel matrix is ​​Carbomer 941.

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Abstract

The invention discloses a flurbiprofen axetil micro-emulsion gel preparation and a preparation method thereof. The flurbiprofen axetil micro-emulsion gel preparation is characterized in that the preparation is composed of a gel substrate and a therapeutically effective amount of medicine-containing micro-emulsion loaded on the substrate. The preparation method provided by the invention has the advantages of simple process and easy operation. The prepared micro-emulsion gel preparation can be prepared into patches, such that a novel administration mode of flurbiprofen axetil is provided, and flurbiprofen axetil efficacy and application efficiency are improved.

Description

technical field [0001] The invention relates to a flurbiprofen axetil microemulsion gel preparation and a preparation method thereof. Background technique [0002] Flurbiprofen axetil has unique pharmacological effects in analgesic efficacy, and has been widely used for perioperative analgesia in medical operations. The acute pain response is caused by the stimulation of nerve ending pain receptors caused by noxious and pathological stimuli, and the excitement is transmitted to the central cerebral cortex through nerve impulses. According to available data, there are 23 million operations in the United States every year, and 50% of patients have unrelieved or inadequately treated pain due to insufficient medication. Pain in the acute phase not only causes great physical and mental pain to patients, but also affects the immune and digestive functions of the body. Previous studies have shown that: Surgical trauma can cause systemic stress response, and pain can cause many ne...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/70A61K31/222A61K47/32A61K47/38A61P29/00
Inventor 刘传荣陈思浩杨秋杰包一鸣王继虎邢晨晨王锦成楼建中
Owner SHANGHAI UNIV OF ENG SCI
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