Preparation method and applications of queen lagerstroemia folium apocyni veneti general flavones

A technology of total flavonoids and concentrates, which is applied in the field of preparation of drugs for the prevention and treatment of Alzheimer's disease, can solve the problems of large amount of organic solvents, unfavorable human health, serious environmental pollution, etc., achieve fewer separation steps and shorten the production cycle , the effect of high enrichment rate

Inactive Publication Date: 2013-02-20
URUMQI GENERAL HOSPITAL LANZHOU MILITARY AREA CHINESE P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods all have the disadvantages of low extraction rate, large amount of organic solvent, long processing time, serious environmental pollution, and unfavorable to human health.

Method used

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  • Preparation method and applications of queen lagerstroemia folium apocyni veneti general flavones

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take the dried Apocynum large flower medicinal material and grind it, pass through a 20-mesh sieve, take 2kg of the medicinal powder, add 10 times the concentration of 60% ethanol solution, heat and reflux for 1 hour to extract twice, combine the extracts, filter, recover the ethanol, and concentrate to Measure the relative density at 50°C to be 1.10-1.20 to obtain a concentrated solution;

[0019] Dilute the concentrate with water to make medicine : liquid medicine=1 : 1 solution (referring to diluting the concentrated solution with water to a solution equal to the weight and volume of the medicinal materials, that is, 100g of medicinal materials, diluting the concentrated solution to 100ml), standing still, filtering, and centrifuging the filtrate at 15,000 rpm. The clear liquid is desedimented and filtered with a microfiltration membrane with a pore size of 0.02 μm, the transmembrane pressure is 0.5 Mpa, and the temperature of the feed liquid is 30 ° C to obtain the...

Embodiment 2

[0024] Take the dried Apocynum large flower medicinal material and grind it, pass through a 30-mesh sieve, take 2kg of medicinal powder, add 8 times the concentration of 70% ethanol solution, heat and reflux for 2 hours to extract twice, combine the extracts, filter, recover ethanol, and concentrate to Measure the relative density at 50°C to be 1.10-1.20 to obtain a concentrated solution;

[0025] Dilute the concentrate with water to make medicine : liquid medicine=1 : 1 solution, let stand, filter, the filtrate is centrifuged at 15000 rpm, the supernatant obtained after centrifugation is taken, and the microfiltration membrane with a pore size of 0.04 μm is desedimented and filtered, the transmembrane pressure is 1.0Mpa, and the temperature of the feed liquid is 40°C , get permeate;

[0026] The obtained permeate is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000, the transmembrane pressure is 1.0Mpa, and the feed liquid temperature is...

Embodiment 3

[0030] Take the dried Apocynum large flower medicinal material and grind it, pass through a 40 mesh sieve, take 2kg of the medicinal powder, add 9 times the concentration of 70% ethanol solution, heat and reflux for 1 hour to extract 3 times, combine the extracts, filter, reclaim the ethanol, and concentrate to Measure the relative density at 50°C to be 1.10-1.20 to obtain a concentrated solution;

[0031] Dilute the concentrate with water to make medicine : liquid medicine=1 : 1 solution, let stand, filter, the filtrate is centrifuged at 15000 rpm, the supernatant obtained after centrifugation is taken, and the microfiltration membrane with a pore size of 0.08 μm is desedimented and filtered, the transmembrane pressure is 1.0Mpa, and the temperature of the feed liquid is 40°C , get permeate;

[0032] The obtained permeate is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 8000, the transmembrane pressure is 1.0Mpa, and the feed liquid tempe...

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Abstract

The invention relates to a preparation method and applications of queen lagerstroemia folium apocyni veneti general flavones. The method adopts a membrane separation technology to extract and separate extract of queen lagerstroemia folium apocyni veneti so as to obtain queen lagerstroemia folium apocyni veneti general flavones; and animal test proves that the queen lagerstroemia folium apocyni veneti general flavones obtained by the method have good preventive and therapeutic effect on Alzheimer's disease, thereby effectively solving the problem of medicament for preventing and treating Alzheimer's disease, realizing prevention and treatment on Alzheimer's disease, and developing new medical value of queen lagerstroemia folium apocyni veneti general flavones.

Description

technical field [0001] The invention relates to a preparation method and application of total flavonoids from Apocynum grandiflora leaves, in particular to the application of total flavonoids extracted and separated from Apocynum grandiflora leaves in the preparation of drugs for preventing and treating Alzheimer's disease. Background technique [0002] Alzheimer's disease , Alzheimer's disease (AD), also known as senile dementia, is a progressive degenerative disease of the central nervous system that is more common in middle-aged and elderly people, with progressive cognitive impairment, mental decline and personality changes as the main clinical manifestations. At present, it has become the fourth cause of death after heart disease, malignant tumor and stroke in the elderly population. At present, the pathogenesis of AD is not yet clear, and there is no effective treatment. Western medicine mainly uses drugs such as cholinesterase inhibitors, glutamate receptor antagonis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/24A61P25/28A61K127/00
Inventor 周军张琼孙江兵雷权曾平卢静
Owner URUMQI GENERAL HOSPITAL LANZHOU MILITARY AREA CHINESE P L A
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