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Open trap mass spectrometer

A technology of mass spectrometry and mass spectrometry, which is applied in the fields of electrostatic traps, multi-pass time-of-flight mass spectrometers, and mass spectrometry, and can solve the problems of slow acquisition speed mass spectrometers and effective duty ratios limited to less than 0.3 to 1%.

Active Publication Date: 2016-10-12
LECO CORPORATION
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  • Application Information

AI Technical Summary

Problems solved by technology

The slow acquisition speed combined with the space charge limitation of the C-trap limits the duty cycle of the mass spectrometer to 0.3% in the worst case
[0012] Thus, in an attempt to achieve high resolution, state-of-the-art electrostatic traps with image charge detection and multipass time-of-flight mass spectrometers limit the accepted ion flux to below 1E+7i / s, which in the worst case Limits effective duty cycle to less than 0.3 to 1%

Method used

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Embodiment Construction

[0092] prototype

[0093] Referring to Figure 1, prior art SU 1,725,289 incorporated herein by reference, a planar MR-TOF 11 comprises a pulsed ion source 12, a fast response detector 13 and two parallel planar and gridless ion mirrors that form strip electrodes 14 to 19 .

[0094] In operation, the electrostatic gridless ion mirror reflects ion packets in the X direction, while providing spatial ion focusing in the Y direction and synchronized ion oscillation in the X direction. The pulsed ion source 12 generates ion packets with very low divergence and directs these ion packets at an oblique angle relative to the X-axis. While deflecting in the Z direction, the ion packets are reflected between the ion mirrors in such a way that a jigsaw-like ion trajectory is formed until the ion packets hit the detector 13 . For the purpose of increasing the resolving power (resolution), the flight path along the jigsaw-like trajectory is extended compared to single reflection TOF mass s...

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Abstract

An open electrostatic trap mass spectrometer is disclosed for operation with wide and diverging ion packets. Signal on detector is composed of signals corresponding to multiplicity of ion cycles, called multiplets. Using reproducible distribution of relative intensity within multiplets, the signal can be unscrambled for relatively sparse spectra, such as spectra past fragmentation cell of tandem mass spectrometer, past ion mobility and differential ion mobility separators. Various embodiments are provided for particular pulsed ion sources and pulsed converters such as orthogonal accelerators, ion guides, and ion traps. The method and apparatus enhance the duty cycle of pulsed converters, improve space charge tolerance of the open trap analyzer and extends the dynamic range of time-of-flight detectors.

Description

technical field [0001] The present invention relates generally to the field of mass spectrometry, electrostatic traps, and multipass time-of-flight mass spectrometers, and more particularly to devices and methods of use comprising open electrostatic traps having non-fixed flight paths. [0002] definition [0003] The present application proposes a novel apparatus and method named herein as "Open Electrostatic Trap". Its characteristics are similar to those of both conventional electrostatic trap (E-trap) and multipass time-of-flight (M-TOF) mass spectrometers. In all three cases, the pulsed ion packets undergo multiple simultaneous oscillations (reflections or turns) within the electrostatic analyzer. The differences between these techniques are defined by the arrangement of electrostatic fields, by ion trajectories and by detection principles. In a conventional E-trap, the field traps ions in all three directions, and ions can be trapped indefinitely. In M-TOF, ion packe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/40
CPCH01J49/406H01J49/0036H01J49/06H01J49/282H01J49/40H01J49/401H01J49/4245H01J49/48
Inventor 阿纳托利·韦列奇科夫
Owner LECO CORPORATION