Cellular constituents from bacteroides, compositions thereof, and therapeutic methods employing bacteroides or cellular constituents thereof
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A technology of Bacteroides and composition, which is applied in the direction of functions such as bacterial medical raw materials, drug combinations, and food ingredients
Inactive Publication Date: 2013-02-27
MOORE RES ENTERPRISES
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Although the exact mechanism is not fully elucidated, the consensus is that chronic, low-grade obesity-induced inflammation (e.g. through activation of protein kinases such as IkB kinase (IKK) and Jun kinase (JNK)) is an important factor (Hotamisligil, G.S. 2006. Inflammation and metabolic disorders (inflammation and metabolic disorders). Nature.444:860; Shoelson, S.E. et al., 2006.Inflammation and insulin resistance (inflammation and insulin resistance). J.Clin.Invest.116:1793; White, C.R.2003.Insulin Signaling in health and disease (insulin signaling under health and disease). Science.302:1710; Solinas, G.C. et al., 2007. JNK1 in hematopoieticllyderived cells contributes to diet-induced inflammation and insulin resistance withoutaffecting obesity (in hematopoietic derived cells JNK1 Contributes to Diet-Induced Inflammation and Insulin Resistance Without Affecting Obesity). Cell Metabol. 6:386)
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Embodiment 1
[0062] This example demonstrates the preparation of cellular components for use in therapeutic compositions.
[0063] Bacterial cell cultures are grown in vats under strictly controlled conditions. Cellular components, such as proteins, obtained from the bacterial cells themselves by lysing the cells, extracting and purifying them, or alternatively from stimulating the bacteria to produce proteins, for example, by varying conditions such as pH, temperature, oxygen, nutrients, or other variables obtained from bacterial cell secretions. Sterile glass Petri dishes / tubes are then inoculated with medium containing lysed cells and / or protein and suspending medium including but not limited to eg up to 10% skim milk with or without 5% sodium tartrate. The material is then eg subjected to centrifugation and washed with a suitable sterile medium (eg suspending medium or buffer solution). Usual additives for freeze-drying may be added, including protectants, stabilizers, buffers, and t...
Embodiment 2
[0065] This example shows a suitable capsule product.
[0066] Using the freeze-drying method, a certain amount of cell components derived from Bacteroides polymorpha cells was prepared in powder form ("active ingredient 1") using the procedure as described in Example 1 .
[0067] Table 1
[0068]
[0069] Components 1-4 from Table 1 were mixed for 10 minutes in a suitable mixer. After mixing, 450 mg of the mixture is filled into two gelatin or hypromellose capsules, and the capsules are sealed.
Embodiment 3
[0071] This example shows a suitable tablet product.
[0072] Using the lyophilization method as described in Example 1, a certain amount of cell components derived from Bacteroides monomorpha cells was prepared in powder form ("active ingredient 2").
[0073] Table 2
[0074]
[0075] Components 1-3 from Table 2 were mixed for 10 minutes in a suitable mixer. The mixture is then compressed into 450 mg tablets using a tablet machine.
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Abstract
A cellular constituent is lysed from, produced by and / or isolated from one or more bacteria from the genus Bacteroides, and the cellular constituent, a derivative thereof, and / or one or more bacteria from the genus Bacteroides, or a modified form thereof, is employed in compositions and methods for modulating an inflammatory response.; Such methods include methods of treating, delaying the onset of, or reducing the symptoms of one or more inflammatory conditions / diseases, including corporal or gastrointestinal inflammation, for example, Irritable Bowel Syndrome, Crohn's Disease, or colitis, and / or associated diseases such diabetes, asthma, multiple sclerosis, cancer, rheumatoid arthritis, gingivitis, atopic diseases, for example, hay fever, food allergies, eczema, rhinitis, dermatitis, conjunctivitis, atopic syndrome and keratosis pelaris, ocular inflammatory disease, strokes, cardiovascular disease, depression, atherosclerosis and hypertension, and comprise administering a composition comprising one or more natural and / or modified bacteria of the genus Bacteroides, and / or a cellular constituent lysed from, produced by, or isolated from one or more natural and / or modified bacteria from the genus Bacteroides, or a derivative thereof.
Description
field of invention [0001] The present invention relates to cellular components and derivatives thereof derived from bacteria of the genus Bacteroides, compositions comprising such cellular components or derivatives thereof and the use of such cellular components or derivatives thereof or derived from Bacteroides bacterium, or a genetically modified form thereof, including methods for treating, delaying the onset or reducing the symptoms of one or more inflammatory conditions / diseases involving the body or the gastrointestinal tract Inflammation and / or related diseases such as diabetes, asthma, multiple sclerosis, cancer, rheumatoid arthritis, gingivitis, atopy, ocular inflammatory disease, stroke, cardiovascular disease, depression, atherosclerosis and hypertension blood pressure. Background of the invention [0002] The health of the human host depends on the ability of the immune system to recognize and adapt to a myriad of foreign and self molecules and to respond in an ...
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