Preparation method of sustained release preparation containing ibuprofen mini-pills

A technology of sustained-release preparations and pellets, which is applied in the field of medicine, can solve problems such as insignificant therapeutic effect, unstable blood drug concentration, and large side effects, and achieve the effects of reducing compliance, easy industrial production, and quick onset of action

Inactive Publication Date: 2013-03-13
SHANXI YUNPENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are many drugs for treating rheumatoid arthritis on the market, such as indomethacin enteric-coated tablets, etc., but these drugs have the problems of unstable blood drug concentration, frequent medication, and large side effects, and the therapeutic effect is not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of preparation method of the sustained-release preparation containing ibuprofen pellets is carried out according to the following steps:

[0027] first step, weighing

[0028] Weigh the raw materials used according to the following parts by weight: 35 parts of ibuprofen, 10 parts of lactose, 1 part of microcrystalline cellulose, 1 part of hypromellose, 10 parts of medicinal ethanol, the medicinal ethanol is the volume percentage concentration of 95% aqueous solution;

[0029] The second step, mixing

[0030] uniformly mixing the ibuprofen, lactose and microcrystalline cellulose to obtain a mixed raw material;

[0031] dissolving the hypromellose in the medicinal ethanol completely to obtain an adhesive;

[0032] The third step, making pellets

[0033] Put the mixed raw material into the pelletizing machine, spray the binder, and centrifuge to make pellets;

[0034] The pellets were dried at 40° C. for 120 minutes, then the adhering pellets were removed with ...

Embodiment 2

[0036] A kind of preparation method of the sustained-release preparation containing ibuprofen pellets is carried out according to the following steps:

[0037] first step, weighing

[0038] The raw materials used are weighed according to the following parts by weight: 30 parts of ibuprofen, 8 parts of lactose, 5 parts of microcrystalline cellulose, 3 parts of hypromellose, 13 parts of medicinal ethanol, and the medicinal ethanol has a volume percentage concentration of 95% aqueous solution;

[0039] The second step, mixing

[0040] uniformly mixing the ibuprofen, lactose and microcrystalline cellulose to obtain a mixed raw material;

[0041] dissolving the hypromellose in the medicinal ethanol completely to obtain an adhesive;

[0042] The third step, making pellets

[0043] Put the mixed raw material into the pelletizing machine, spray the binder, and centrifuge to make pellets;

[0044] The pellets were dried at 45° C. for 100 minutes, then the adhering pellets were rem...

Embodiment 3

[0046] A kind of preparation method of the sustained-release preparation containing ibuprofen pellets is carried out according to the following steps:

[0047] first step, weighing

[0048] The raw materials used are weighed according to the following parts by weight: 28 parts of ibuprofen, 6 parts of lactose, 4 parts of microcrystalline cellulose, 2 parts of hypromellose, 12 parts of medicinal ethanol, and the medicinal ethanol has a volume percentage concentration of 95% aqueous solution;

[0049] The second step, mixing

[0050] uniformly mixing the ibuprofen, lactose and microcrystalline cellulose to obtain a mixed raw material;

[0051] dissolving the hypromellose in the medicinal ethanol completely to obtain an adhesive;

[0052] The third step, making pellets

[0053] Put the mixed raw material into the pelletizing machine, spray the binder, and centrifuge to make pellets;

[0054] The pellets were dried at 42° C. for 90 minutes, then the adhering pellets were remo...

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PUM

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Abstract

The invention relates to the field of drugs, in particular to a preparation method of a sustained release preparation containing ibuprofen mini-pills. The technical problem to be solved is to provide the sustained release preparation containing ibuprofen mini-pills. A relative substance detection method is added for the medicament by our company by reference to the British Pharmacopoeia. The medical property of the medicament is released stably and lastingly, and the safety and effectiveness of the medicament are really achieved. The adopted technical is as follows: weighing the following raw materials in parts by weight: 25-35 parts of ibuprofen, 3-10 parts of milk sugar, 1-5 parts of microcrystalline cellulose, 1-5 parts of hydroxypropyl methylcellulose and 10-15 parts of medicinal ethanol; then mixing the materials and spraying an adhesive into the materials to obtain the ibuprofen sustained release preparation. The preparation method of the sustained release preparation containing ibuprofen mini-pills is widely applied to the pharmaceutical field of the ibuprofen.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a preparation method of a slow-release preparation containing ibuprofen pellets. Background technique [0002] Rheumatoid arthritis is a common acute or chronic inflammation of connective tissue. Can be recurrent and involve the heart. Clinical one is characterized by migratory soreness, heaviness, and pain in joints and muscles. An allergic disease. It is one of the main manifestations of rheumatic fever, mostly with acute fever and arthralgia onset. [0003] Rheumatoid arthritis is a manifestation of rheumatic fever. Rheumatic fever is a systemic allergic disease caused by group A beta-hemolytic streptococcus infection, and there are often infection medical histories such as erysipelas at the beginning of the disease. Rheumatic fever has an acute onset, and rheumatic arthritis can invade the heart, causing rheumatic heart disease, and performances such as heating, subcutaneous n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/192A61K47/38A61P29/00A61P19/02
Inventor 张俊萍
Owner SHANXI YUNPENG PHARMA
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